Results 121 to 130 of about 80,718 (256)

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Tn Antigen [PDF]

, 2020
openaire   +1 more source

R3Net: Recursive Residual Refinement Network Architecture for Decoder‐Free Medical Image Segmentation

Precision Radiation Oncology, EarlyView.
We propose R3Net, a decoder‐free medical image segmentation framework that recursively refines multiscale representations within the encoder using residual pathways. R3Net achieves competitive accuracy with reduced model complexity and improved computational efficiency across multiple medical imaging modalities.
Jing Huang, Yongkang Zhao, Yuhan Li, Zhitao Dai, Cheng Chen, Qiying Lai   +5 more
wiley   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine.

European journal of histochemistry : EJH, 2000
Tn, sialosyl-Tn and T antigens are simple mucin-type carbohydrate antigens that may be expressed in human neoplasies due to alteration of the glycoprotein biosynthetic pathway. Utilising specific monoclonal antibodies (HB-Tn1, HB-STn1 and HB-T1), we have investigated the expression of these simple mucin-type carbohydrate antigens in large intestine of ...
GROSSO, Maddalena, VITARELLI E, GIUFFRE', Giuseppe, TUCCARI, Giovanni, BARRESI, Gaetano   +4 more
openaire   +4 more sources

Electrocatalytically Amplified Immunosensing Enabled by Titanium Oxynitride‐Supported Ru Nanodots on Graphene Oxide Hybrid Architecture

Small, EarlyView.
A synergistic effect among the electrocatalytic Ru/TiON‐GO nanocomposite, biorecognition elements, and the [Fe(CN)6]3−/4− redox probe for highly sensitive and selective impedimetric detection of PSA protein in human serum was demonstrated. The immunosensor exhibited a limit of detection of only 0.06 ng mL−1 PSA protein, underscoring the importance and ...
Mitja Koderman, Milutin Smiljanić, Filip Cernatič, Marjan Bele, Francisco Ruiz‐Zepeda, Nejc Hodnik, Mitja Kolar, Samo B. Hočevar, Nikola Tasić   +8 more
wiley   +1 more source

Tn Antigen Expression Defines an Immune Cold Subset of Mismatch-Repair Deficient Colorectal Cancer. [PDF]

Int J Mol Sci, 2020
Matsumoto T, Okayama H, Nakajima S, Saito K, Nakano H, Endo E, Kase K, Ito M, Yamauchi N, Yamada L, Kanke Y, Onozawa H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Mimura K, Kono K.   +18 more
europepmc   +1 more source

Transposons as Tools for Future Genome Engineering in Yeasts and Filamentous Fungi

Yeast, EarlyView.
Applications of transposon‐based tools for genome engineering in fungi include transposon‐mediated mutagenesis and targeted genomic integration. ABSTRACT Transposons are fundamental genetic elements that have profoundly shaped the architecture of eukaryotic genomes.
Bingyin Peng, Masahiro Tominaga, Chengqiang Wang, Robert E. Speight, Jun Ishii   +4 more
wiley   +1 more source

Sialyl Tn Antigen [PDF]

, 2020
openaire   +1 more source

TriCrackNet: Trilateral Segmentation Network for Real‐Time Crack Segmentation

CAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT To achieve high‐precision real‐time crack segmentation, we propose TriCrackNet, an efficient network based on a tri‐branch collaborative architecture incorporating boundary constraints, semantic parsing, and spatial refinement. In the semantic branch, efficient atrous spatial pyramid pooling (EASPP) is integrated.
Haixin Jia, Han Wang, Xiaoqiang Shi, Guoying Zhang, Hanqi Jiang, Jianbo Peng   +5 more
wiley   +1 more source