Results 101 to 110 of about 551,022 (291)
Tn antigen interactions of macrophage galactose-type lectin (MGL) in immune function and disease. [PDF]
Glycobiology, 2023 Tumoglu B, Keelaghan A, Avci FY.
europepmc +1 more source
, 2000 International audienceGlycopeptides containing a tumor-associated carbohydrate antigen (mono-, tri- or hexa-Tn antigen) as a B-cell epitope and a CD4+ T-cell epitope (PV: poliovirus or TT: tetanus toxin) were prepared for immunological studies.
Deriaud, E. +6 more
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Systemic lupus erythematosus (SLE) is characterized by type I interferon (IFN) signaling and adaptive immune dysregulation. We previously identified hypomethylation of HLA‐DRB1 and STAT1 in SLE CD8+ T cells, enabling aberrant IFN‐driven HLA‐DRB1 expression and expansion of a distinct CD8+ T cell subset. This study characterized CD8+ HLA‐DRB1+
Huizhong Long +3 more
wiley +1 more source
Immunohistochemical study of Tn, sialosyl-Tn and T antigens in human meningiomas.
European journal of histochemistry : EJH, 1998 Since an aberrant glycosylation associated with abnormal expression of cell surface carbohydrates has been described in many human tumours, we have investigated the expression of simple mucintype carbohydrate antigens (Tn, sialosyl-Tn and T) in 30 formalin-fixed paraffin-embedded surgical specimens of primary meningiomas, subdivided according to the ...
GIUFFRE', Giuseppe +3 more
openaire +2 more sources
Structural basis for the specificity of basic winged bean lectin for the Tn-antigen: A crystallographic, thermodynamic and modelling study [PDF]
, 2005 The crystal structure of winged bean basic agglutinin in complex with GalNAc-α-O-Ser (Tn-antigen) has been elucidated at 2.35Å resolution in order to characterize the mode of binding of Tn-antigen with the lectin.
Samiksha Katiyar +12 more
core +1 more source
BMEMat, EarlyView.This work discovered a novel research that ultrasmall Fe‐curcumin immunomodulators could reinvigorate CAR‐T cells to potentiate solid tumor immunotherapy by mitigating cell exhaustion and senescence. Abstract CAR‐T cell immunotherapy has achieved exciting success in hematologic malignancies, but the therapeutic efficacy is relatively limited in solid ...
Jiazhi Duan +15 more
wiley +1 more source
Sialyl-Tn Antigen-Imprinted Dual Fluorescent Core-Shell Nanoparticles for Ratiometric Sialyl-Tn Antigen Detection and Dual-Color Labeling of Cancer Cells. [PDF]
ACS Appl Nano Mater, 2022 Jiang S +6 more
europepmc +1 more source
BMEMat, EarlyView.Leveraging bacterial hypoxia targeting, KBTO NPs accumulate at the tumor site. Under the ultrasound irradiation, KBTO NPs produce reactive oxygen species to kill tumor cells and eliminate bacteria, preventing overgrowth and inflammation. The lysed bacteria act as antigens to trigger antitumor immunity and further enhanced by the immune checkpoint ...
Chongyang Liu +12 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Model‐informed drug development is increasingly used to support chimeric antigen receptor (CAR)‐T‐cell therapy programs. However, most population pharmacokinetic (PK) CAR‐T‐cell models available in literature are variations of an empirical piecewise‐linear model, which accurately describes the observed data but lacks a mechanistic foundation.
Anna M. Mc Laughlin +4 more
wiley +1 more source
Transplant nephrectomy - A single-center experience
Saudi Journal of Kidney Diseases and Transplantation, 2015 Transplant nephrectomy (TN) is associated with significant morbidity and mortality and influences the outcome of subsequent renal transplantation. The aim of this study was to identify the reasons for TN in a single transplant center in the United ...
Arun Ariyarathenam +2 more
doaj +1 more source