Results 161 to 170 of about 551,022 (291)

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres, Cristobalina Mayorga, Elizabeth J. Phillips, Adriana Ariza, Annick Barbaud, Patrizia Bonadonna, Mariana Castells, Gülfem Çelik, Knut Brockow, Lene H. Garvey, Inmaculada Doña, Jean‐Christoph Caubet, Francesca Mori, Jason Trubiano, Giorgia Marta, Antonino Romano, Ingrid Terreehorst, Asli Gelincik, Philip H. Li, Vito Sabato   +19 more
wiley   +1 more source

Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue. [PDF]

Chem Sci, 2020
Pifferi C, Ruiz-de-Angulo A, Goyard D, Tiertant C, Sacristán N, Barriales D, Berthet N, Anguita J, Renaudet O, Fernández-Tejada A.   +9 more
europepmc   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Effects of chronic lymphocytic leukaemia (CLL)‐directed therapy on diffuse large B‐cell lymphoma (DLBCL) type Richter transformation compared to de novo DLBCL in a nationwide cohort

British Journal of Haematology, EarlyView.
Summary Diffuse large B‐cell lymphoma (DLBCL) type Richter transformation (DLBCL‐RT) in patients with chronic lymphocytic leukaemia (CLL) has a worse prognosis compared to de novo DLBCL (dnDLBCL). We investigated outcomes of patients with DLBCL‐RT with or without previous CLL‐directed therapy compared to dnDLBCL between 2002 and 2022.
Andreas Katsimigas, Mikkel Werling, Casper M. Frederiksen, Noomi Vainer, Klaus Rostgaard, Yasmin Ben‐Dali, Mariam H. Hleuhel, Christian Brieghel, Carsten U. Niemann, Caspar da Cunha‐Bang   +9 more
wiley   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, EarlyView.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

Studies on a Sulfoxide-Bridged Tn Antigen Mimetic: Interaction with Macrophage Galactose Lectin and Inhibition of Sialyltransferase ST6GALNAC1. [PDF]

ACS Omega
Sodini A, Casali E, Travecedo MA, Marcelo F, Chiodo F, Rambaldi F, van Vliet SJ, Dall'Olio F, Nativi C.   +8 more
europepmc   +1 more source

Development of a scalable synthesis of the Sialyl-Tn antigen

Amandeep Sehmbi Uwill abstract Development of a scalable synthesis of the Sialyl-Tn antigen Amandeep Sehmbi, Michael Reynolds, John F. Trant The sialyl-Tn antigen (sTn) is a naturally occurring carbohydrate commonly associated with epithelial cancers ...
Sehmbi, Amandeep
core  

Adjusted delivery, stronger outcomes: Selinexor therapeutic adaptation and positioning in previously treated multiple myeloma

British Journal of Haematology, EarlyView.
In patients with lenalidomide‐refractory multiple myeloma from the BOSTON trial subgroup analysis,1 selinexor (SEL) dose reduction versus full dosing substantially improved efficacy outcomes, including higher overall response rate (74.3% vs. 55.6%), deeper responses (≥ very good partial response: 48.6% vs.
Muhamed Baljevic
wiley   +1 more source

Mass Spectrometric Mapping of Glycoproteins Modified by Tn-Antigen Using Solid-Phase Capture and Enzymatic Release. [PDF]

Anal Chem, 2020
Yang W, Ao M, Song A, Xu Y, Sokoll L, Zhang H.   +5 more
europepmc   +1 more source

AI‐based anatomical recognition for bladder neck dissection in robot‐assisted radical prostatectomy

BJU International, EarlyView.
Objective To develop an artificial intelligence (AI) system for anatomical recognition that can automatically identify key anatomical structures during bladder neck dissection in robot‐assisted radical prostatectomy (RARP), a critical yet technically demanding step.
Shinnosuke Fujiwara, Keishiro Fukumoto, Masashi Takeuchi, Yuichiro Konnai, Yota Yasumizu, Nobuyuki Tanaka, Toshikazu Takeda, Kazuhiro Matsumoto, Takeo Kosaka, Hirofumi Kawakubo, Masaru Ishida, Yuko Kitagawa, Mototsugu Oya   +12 more
wiley   +1 more source