Results 41 to 50 of about 551,022 (291)

Anti-Tn Monoclonal Antibody Ameliorates Hyperoxia-Induced Kidney Injury by Suppressing Oxidative Stress and Inflammation in Neonatal Mice

Mediators of Inflammation, 2021
The Tn antigen, an N-acetylgalactosamine structure linked to serine or threonine, has been shown to induce high-specificity, high-affinity anti-Tn antibodies in mice.
Julie Chi Chow, Hsiu-Chu Chou, Jaulang Hwang, Chung-Ming Chen   +3 more
doaj   +1 more source

Tn, a carcinoma-associated antigen, reacts with anti-Tn of normal human sera [PDF]

Cancer, 1985
Tn antigen is the immediate precursor of the carcinoma (CA)-associated T antigen; both are masked in non-CA tissues. Tn antigen was detected by absorption of human anti-Tn antibody in 46 of 50 primary breast CAs and in all 6 metastases originating from Tn-positive primary CAs.
G F, Springer, C R, Taylor, D R, Howard, H, Tegtmeyer, P R, Desai, S M, Murthy, B, Felder, E F, Scanlon   +7 more
openaire   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Tn Antigen Mimics by Ring-Opening of Chiral Cyclic Sulfamidates with Carbohydrate C1-S- and C1-O-Nucleophiles [PDF]

, 2018
Starting from commercially available (S)-isoserine and effectively accessible (S)-α-methylserine, enantiopure cyclic sulfamidates have been prepared as chiral building blocks for the synthesis of various S- and O-glycosylated amino acid derivatives ...
Oroz, P. [0000-0003-0854-5059], Gonzalo Jiménez-Osés, Corzana, F. [0000-0001-5597-8127], Peregrina, J.M. [0000-0003-3778-7065], Avenoza, A. [0000-0002-5465-3555], Busto, J.H. [0000-0003-4403-4790], García, I., Nuria Mazo, Pablo Tovillas, Paula Oroz, Jesús H. Busto, Jesús M. Peregrina, Iván García, Mazo, N. [0000-0001-6049-0871], Jiménez-Osés, G. [0000-0003-0105-4337], Tovillas, P., Alberto Avenoza, Francisco Corzana   +17 more
core   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

Aberrant Glycosylation of Anchor-Optimized MUC1 Peptides Can Enhance Antigen Binding Affinity and Reverse Tolerance to Cytotoxic T Lymphocytes

Biomolecules, 2016
Cancer vaccines have often failed to live up to their promise, although recent results with checkpoint inhibitors are reviving hopes that they will soon fulfill their promise. Although mutation-specific vaccines are under development, there is still high
Latha B. Pathangey, Vani Lakshminarayanan, Vera J. Suman, Barbara A. Pockaj, Pinku Mukherjee, Sandra J. Gendler   +5 more
doaj   +1 more source

Evaluation of serum CA125-Tn glycoform in peritoneal dissemination and surgical completeness of high-grade serous ovarian cancer

Journal of Ovarian Research, 2022
Background Peritoneal dissemination is the predominant feature of malignant progression in ovarian cancer and is a major cause of poor surgical outcomes and clinical prognoses. Abnormal glycosylation of carbohydrate antigen 125 (CA125) may be involved in
Xiayu Jin, Ming Du, Yisheng Wang, Yuefei Wang, Yingying Lu, Congjian Xu, Xiaoyan Zhang   +6 more
doaj   +1 more source

Tn-syndrome [PDF]

, 1999
The idiopathic Tn-syndrome, formerly called ‘permanent mixed-field polyagglutinability’, is a rare hematological disorder characterized by the expression of the Tn-antigen on all blood cell lineages.
Berger, Eric G
core   +1 more source

Tuning CAR-T cells by targeting cancer-associated glycan in pancreatic cancer

Nature Communications
Chimeric antigen receptor (CAR) T cell therapy has transformed cancer treatment but its efficacy remains limited in solid tumors due to antigen heterogeneity, an immunosuppressive microenvironment, and the glycocalyx barrier.
Sangwoo Park, Cassidy E. Ho, Eli P. Darnell, Alexandra N. Wolff, Hana Takei, Filippo Birocchi, Amanda A. Bouffard, Diego Salas-Benito, Giulia Escobar, Mark B. Leick, Adele Mucci, Trisha R. Berger, Marcela V. Maus   +12 more
doaj   +1 more source