Results 171 to 180 of about 80,856 (259)

Optimal Selection of the Effective Echo Time (TEeff ) for T2‐Weighted Fast‐Spin‐Echo MRI of the Prostate at 3.0 T: Effect on Lesion Conspicuity

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 616-628, September 2026.
ABSTRACT Background Clinical T 2‐weighted (T2W) MRI of prostate cancer (PCa) usually implements a 2D fast‐spin‐echo (FSE) sequence, but understanding the echo‐time‐dependent contrast behavior is not straightforward due to the complicated FSE signal evolution.
Dahan Kim, Ronard Pabi, Eric A. Borisch, Adam T. Froemming, Roger C. Grimm, Sara Hassanzadeh, Akira Kawashima, Ayumu Kido, Naoki Takahashi, John V. Thomas, Stephen J. Riederer   +10 more
wiley   +1 more source

Systematic Review of AI‐Driven Applications for Screening Nasopharyngeal Carcinoma Using MRI

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 593-615, September 2026.
ABSTRACT Background Nasopharyngeal carcinoma (NPC) can be detected early on MRI, but adoption for screening is limited by a shortage of experienced specialists. MRI artificial intelligence (AI) algorithms for diagnosing NPC in the literature may address this, but most studies focus on routine clinical care, and their applicability in screening requires
Lun M. Wong, Ho Sang Leung, Zuyao Yang, Yip Man Tsang, Yuet Ting Chan, Tiffany Y. So, Ann D. King, Qi Yong H. Ai   +7 more
wiley   +1 more source

Dynamic Granulocyte Turnover Inferred From cfDNA Methylation Predicts Immunotherapy Benefit in Liver‐Metastatic Small Cell Lung Cancer: A Prospective Biomarker Study

MedComm, Volume 7, Issue 9, September 2026.
This prospective study evaluated envafolimab plus chemotherapy in 29 SCLC patients with liver metastases, integrating multi‐omics analyses (WES, RNA‐seq, DNA methylation, ctDNA, and cfDNA methylation). The research framework encompassed granulocyte turnover dynamics, prognostic risk modeling, molecular mechanism exploration across risk strata, and ...
Ning Tang, Xiaoling Shang, Yulan Sun, Yingqian Zhang, Haiyan Zhou, Shucheng Ye, Xiaoyong Tang, Jun Guo, Xiqin Zhang, Xuan Gao, Zhehai Wang, Haiyong Wang   +11 more
wiley   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

Intermediate clinical endpoints as surrogates for overall survival after salvage prostatectomy

BJU International, Volume 138, Issue 3, Page 430-437, September 2026.
Objectives To evaluate biochemical recurrence‐free survival (BRFS) and metastasis‐free survival (MFS) as potential intermediate clinical endpoints (ICEs) for overall survival (OS) in patients undergoing salvage radical prostatectomy (sRP). Patients and Methods Evaluable patients were selected from a retrospective dataset, resulting in a cohort of 879 ...
Navid Roessler, Zuzanna Nowicka, Marcin Miszczyk, Giorgio Calleris, Alessandro Dematteis, Malte W. Vetterlein, Simone Albisinni, Henk G Van Der Poel, Paul Cathcart, Giovanni E. Cacciamani, Inderbir S. Gill, Raj A. Persad, Steven Joniau, Rafael Sanchez‐Salas, Joseph A. Smith Jr, Robert Jeffrey Karnes, Mohamed E. Ahmed, Pawel Rajwa, Derya Tilki, Shahrokh F. Shariat, Paolo Gontero, Giancarlo Marra, on behalf of the Young Academic Urologists Prostate Cancer Working Party   +22 more
wiley   +1 more source

STHLM3 NorDCaP: prospective multicentre trial of Stockholm3 for active surveillance biopsy guidance

BJU International, Volume 138, Issue 3, Page 471-479, September 2026.
Objectives Active surveillance (AS) is the preferred approach for low‐risk prostate cancer (PCa). Recent efforts have explored new biomarkers to reduce the frequency of surveillance biopsy. This study assessed Stockholm3 for predicting PCa upgrading during surveillance biopsies. Materials and Methods The prospective STHLM3‐AS NorDCaP trial included 199
Nicola Giudici, Simone Scuderi, Thorgerdur Palsdottir, Tobias Nordstrom, Martin Eklund, Eva Ferlev Jensby, Michael Borre, Bodil Ginnerup Pedersen, Henrik Grönberg, Karina Dalsgaard Sørensen, Svein R Kjosavik, Anna Lantz   +11 more
wiley   +1 more source

Two Paralogues as They Like It: Conserved and Divergent Evolution of Vertebrate Gcm Genes

Evolution &Development, Volume 28, Issue 3, September 2026.
Comparative overview of Gcm1 and Gcm2 paralogues across vertebrates. Gcm2 is conserved in pharyngeal‐derived organs across gnathostomes, whereas Gcm1 shows lineage‐specific diversification from an ancestral pharyngeal context, including secondary loss in teleosts, distinct expression in bichir gills and skin, and broader expression in mammals ...
Takanori Shono, Norifumi Tatsumi, Tsutomu Miyake, Shigehiro Kuraku, Masataka Okabe   +4 more
wiley   +1 more source

Emerging Techniques in Minimally Invasive Surgery in Hematologic Malignancies

European Journal of Haematology, Volume 117, Issue 3, Page 682-690, September 2026.
ABSTRACT Hematologic malignancies represent the most common cancers in children. While the mainstays of treatment are chemotherapy and potentially hematopoietic stem cell transplant, minimally invasive surgery (MIS) has a role in the diagnosis and management of complications related both to disease and therapy as well as common pediatric surgical ...
Alejandro Chara, Katlyn G. McKay, Harold N. Lovvorn III, Joseph C. Fusco   +3 more
wiley   +1 more source

Control of naive T cell reactivity and peripheral tolerance by ascorbate and TET activity. [PDF]

Sci Adv
Hao X, Bai L, Li J, Xu B, Janke LJ, Palacios G, Guy C, Crawford JC, Fan Y, Rosikiewicz W, Keith J, Le H, He M, Yang D, Steele JA, Pruett-Miller SM, Cheng Y, Hanna JH, Geiger T, Feng Y.   +19 more
europepmc   +1 more source

Sugar Amino Acid Linkers for the Design of [18F]SiFA‐PSMA Radioligands

ChemMedChem, Volume 21, Issue 15, 14 August 2026.
Sugar amino acid (SAA) linkers were incorporated into silicon‐fluoride‐acceptor (SiFA)‐prostate‐specific membrane antigen (PSMA) radioligands to modulate pharmacokinetic properties while preserving efficient 18F isotopic exchange radiolabeling. Furanose‐based SAAs outperformed pyranose analogues, enabling specific tumor visualization by PET despite ...
Narendar R. Gade, Melinda Wuest, Justin J. Bailey, Atul Bhardwaj, Ralf Schirrmacher, Frank Wuest   +5 more
wiley   +1 more source