Results 111 to 120 of about 81,953 (280)

Optimal Selection of the Effective Echo Time (TEeff) for T2‐Weighted Fast‐Spin‐Echo MRI of the Prostate at 3.0 T: Effect on Lesion Conspicuity

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Clinical T2‐weighted (T2W) MRI of prostate cancer (PCa) usually implements a 2D fast‐spin‐echo (FSE) sequence, but understanding the echo‐time‐dependent contrast behavior is not straightforward due to the complicated FSE signal evolution.
Dahan Kim, Ronard Pabi, Eric A. Borisch, Adam T. Froemming, Roger C. Grimm, Sara Hassanzadeh, Akira Kawashima, Ayumu Kido, Naoki Takahashi, John V. Thomas, Stephen J. Riederer   +10 more
wiley   +1 more source

Sialyl-Tn Antigen-Imprinted Dual Fluorescent Core-Shell Nanoparticles for Ratiometric Sialyl-Tn Antigen Detection and Dual-Color Labeling of Cancer Cells. [PDF]

ACS Appl Nano Mater, 2022
Jiang S, Wang T, Behren S, Westerlind U, Gawlitza K, Persson JL, Rurack K.   +6 more
europepmc   +1 more source

IgG Subclass (IgG1‐4) and IgA Autoantibody Profiles Against Muscle‐Specific Kinase in a Greek Cohort

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Muscle‐specific kinase myasthenia gravis (MuSK‐MG) is an autoimmune neuromuscular disorder predominantly mediated by IgG4 autoantibodies disrupting MuSK signaling. The contribution of other isotypes remains incompletely defined. We characterized the serological profile of a Greek cohort of MuSK‐MG patients.
Sofia‐Natsοuko Gkotzamani, Maria Pechlivanidou, Francisca Faber, Cansu Elmas, Vasiliki Zouvelou, Elisabeth Chroni, Dimitrios Tzanetakos, Maria Kourouvani, Marlene Wolfsgruber, Ioannis Zaganas, Dimitra Kolovou, Michael Rentzos, Ariadne Daponte, Maria Chondrogiorgi, Spyridon Konitsiotis, Georgios Nicolaou, Stavroula Salakou, Sotirios Giannopoulos, Konstandinos Lazaridis, Georgios Tsivgoulis, Socrates Tzartos, Inga Koneczny, John S. Tzartos   +22 more
wiley   +1 more source

Solid-phase synthesis of a pentavalent GalNAc-containing glycopeptide (Tn antigen) representing the nephropathy-associated IgA hinge region

, 2010
Incomplete or aberrant glycosylation leading to Tn antigen (GalNAca1-Ser/Thr) expression on human glycoproteins is strongly associated with human pathological conditions, including tumors, certain autoimmune diseases, such as the idiopathic IgA ...
Cummings, R.D., Bolscher, J.G.M., Ju, T.Z., van Die, I.M., Cummings, RD, Jan G.M. Bolscher, Veerman, E.C.I., Tongzhong Ju, Joanna A.E. van Wijk, Kamran Nazmi, Richard D. Cummings, Ju, T., Wijk, J.A.E. van, Judith Brevoord, Brevoord, J., Die, I.M. van, Nazmi, K., van Wijk, J.A.E., Irma van Die, Enno C.I. Veerman, Brevoord, J.C.D., van Die, I.   +21 more
core   +1 more source

Molecular basis of incomplete O-glycan synthesis in MCF-7 breast cancer cells: putative role of MUC6 in Tn antigen expression. [PDF]

, 2005
International audienceAn incomplete elongation of O-glycan saccharide chains in mucins have been found in epithelial cancers, leading to the expression of shorter carbohydrate structures, such as the Tn antigen (GalNAc-O-Ser/Thr).
Bay, Sylvie, Silvia von Mensdorff-Pouilly, Eduardo Osinaga, Sylvie Bay, Freire, Teresa, Osinaga, Eduardo, Teresa Freire, von Mensdorff-Pouilly, Silvia   +7 more
core   +1 more source

Diagnosis and Management of Prenatal Hereditary Pyropoikilocytosis

Prenatal Diagnosis, EarlyView.
ABSTRACT Hereditary pyropoikilocytosis (HPP) is a severe hemolytic anemia caused by variants in SPTA1, SPTB, and EPB41. These weaken horizontal interactions in the erythrocyte cytoskeleton, causing membrane fragmentation and splenic sequestration. It will readily cause fetal anemia and often hydrops fetalis. Prenatal diagnosis requires first ruling out
Connor Hartzell, Samantha Stover, Nora Gibson, Timothy Olson, James Connelly, Matthew Grace, Jennifer Andrews   +6 more
wiley   +1 more source

Transplant nephrectomy - A single-center experience

Saudi Journal of Kidney Diseases and Transplantation, 2015
Transplant nephrectomy (TN) is associated with significant morbidity and mortality and influences the outcome of subsequent renal transplantation. The aim of this study was to identify the reasons for TN in a single transplant center in the United ...
Arun Ariyarathenam, Alex Bamford, Jacob A Akoh   +2 more
doaj   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Phage Display Reveals VLRB-Mediated Recognition of Minimal Tumor Glycan Antigen Sialyl-Tn

Current Issues in Molecular Biology
Sialyl-Tn (sTn) is a tumor-associated carbohydrate antigen (TACA) abundantly expressed by various types of carcinomas. While conventional antibody-based platforms have traditionally been used for the detection and targeting of sTn, alternative binding ...
Mark Rickard N. Angelia, Abigail Joy D. Rodelas-Angelia, Youngrim Kim, Cheolung Yang, Hyeok Jang, Seungpyo Jeong, Jihyun Mun, Kim D. Thompson, Taesung Jung   +8 more
doaj   +1 more source

A previously uncharacterized O-glycopeptidase from Akkermansia muciniphila requires the Tn-antigen for cleavage of the peptide bond. [PDF]

J Biol Chem, 2022
Medley BJ, Leclaire L, Thompson N, Mahoney KE, Pluvinage B, Parson MAH, Burke JE, Malaker S, Wakarchuk W, Boraston AB.   +9 more
europepmc   +1 more source