Results 231 to 240 of about 621,266 (288)

Trajectory identification of high-risk subgroups after colorectal cancer surgery in patients with minimal residual disease: a single-center longitudinal study. [PDF]

J Gastrointest Oncol
Zhang Y, Liang L, Zhou R, Wu S, Zhou Y, Luo J, Zeng Y, Xu N, Wen Z.   +8 more
europepmc   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Distribution and function of human long-lasting T cells in aging and non-small cell lung cancer. [PDF]

Front Immunol
Tan JX, Yu HR, Gu Y, Hong H.
europepmc   +1 more source

Profiling the Glycosignature of Commercial Pepsin‐Soluble Type I Collagen Preparations: A MultiModal Lectin Strategy Reveals Latent Batch Variability

Journal of Biomedical Materials Research Part A, Volume 114, Issue 9, September 2026.
ABSTRACT Type I collagen (Col‐I) is widely used in biomaterials and cell biology, yet the glycosignature of commercial Col‐I preparations remains poorly characterized. Here, we established an integrated lectin‐based workflow to profile the glycan landscape of commercially sourced bovine pepsin‐soluble Col‐I as supplied for biomaterial use.
Mohamed EL‐Melegy, Amir M. Alsharabasy, Abhay Pandit   +2 more
wiley   +1 more source

Optimal Selection of the Effective Echo Time (TEeff ) for T2‐Weighted Fast‐Spin‐Echo MRI of the Prostate at 3.0 T: Effect on Lesion Conspicuity

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 616-628, September 2026.
ABSTRACT Background Clinical T 2‐weighted (T2W) MRI of prostate cancer (PCa) usually implements a 2D fast‐spin‐echo (FSE) sequence, but understanding the echo‐time‐dependent contrast behavior is not straightforward due to the complicated FSE signal evolution.
Dahan Kim, Ronard Pabi, Eric A. Borisch, Adam T. Froemming, Roger C. Grimm, Sara Hassanzadeh, Akira Kawashima, Ayumu Kido, Naoki Takahashi, John V. Thomas, Stephen J. Riederer   +10 more
wiley   +1 more source

Synthesis and In Vivo Immunological Evaluation of Novel Saponin-Antigen Conjugates Incorporating Tumor-Associated Carbohydrate and Peptide Epitopes. [PDF]

Chemistry
Fuentes R, Tonon-Baschirotto P, Aguinagalde L, Fernández-Tejada A.   +3 more
europepmc   +1 more source

Systematic Review of AI‐Driven Applications for Screening Nasopharyngeal Carcinoma Using MRI

Journal of Magnetic Resonance Imaging, Volume 64, Issue 3, Page 593-615, September 2026.
ABSTRACT Background Nasopharyngeal carcinoma (NPC) can be detected early on MRI, but adoption for screening is limited by a shortage of experienced specialists. MRI artificial intelligence (AI) algorithms for diagnosing NPC in the literature may address this, but most studies focus on routine clinical care, and their applicability in screening requires
Lun M. Wong, Ho Sang Leung, Zuyao Yang, Yip Man Tsang, Yuet Ting Chan, Tiffany Y. So, Ann D. King, Qi Yong H. Ai   +7 more
wiley   +1 more source

Control of naive T cell reactivity and peripheral tolerance by ascorbate and TET activity. [PDF]

Sci Adv
Hao X, Bai L, Li J, Xu B, Janke LJ, Palacios G, Guy C, Crawford JC, Fan Y, Rosikiewicz W, Keith J, Le H, He M, Yang D, Steele JA, Pruett-Miller SM, Cheng Y, Hanna JH, Geiger T, Feng Y.   +19 more
europepmc   +1 more source

Dynamic Granulocyte Turnover Inferred From cfDNA Methylation Predicts Immunotherapy Benefit in Liver‐Metastatic Small Cell Lung Cancer: A Prospective Biomarker Study

MedComm, Volume 7, Issue 9, September 2026.
This prospective study evaluated envafolimab plus chemotherapy in 29 SCLC patients with liver metastases, integrating multi‐omics analyses (WES, RNA‐seq, DNA methylation, ctDNA, and cfDNA methylation). The research framework encompassed granulocyte turnover dynamics, prognostic risk modeling, molecular mechanism exploration across risk strata, and ...
Ning Tang, Xiaoling Shang, Yulan Sun, Yingqian Zhang, Haiyan Zhou, Shucheng Ye, Xiaoyong Tang, Jun Guo, Xiqin Zhang, Xuan Gao, Zhehai Wang, Haiyong Wang   +11 more
wiley   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source