Results 31 to 40 of about 621,266 (288)

Targeting Tn-Antigen-Positive Human Tumors with a Recombinant Human Macrophage Galactose CType Lectin

, 2021
Alterations in glycosylation cause the emergence of tumor-associated carbohydrate antigens (TACAs) during tumorigenesis. Truncation of O-glycans reveals the Thomsen nouveau (Tn) antigen, an N-acetylgalactosamine (GalNAc) frequently attached to serine or ...
Maxime Henry (4376956), Corinne Vivès (2384077), Christine Ebel (129858), Amandine Hurbin (749682), Aline Le Roy, Franck Fieschi, François Bulteau (11857258), Jean-Luc Coll, Olivier Renaudet (363908), Amandine Hurbin, Michel Thépaut (1788882), Laetitia Vanwonterghem (11857261), Christine Ebel, Jean-Luc Coll (32116), Michel Thépaut, Franck Fieschi (296308), François Bulteau, Olivier Renaudet, Aline Le Roy (10099505), Maxime Henry, Laetitia Vanwonterghem, Corinne Vivès   +21 more
core   +1 more source

Expression of tumor-associated antigens in breast cancer subtypes

Breast, 2020
Objectives: Tumor-associated antigens (TAAs) are frequently overexpressed in several cancer types. The aim of this study was to investigate the expression of TAAs in breast cancer.
Giuseppe Curigliano, Vincenzo Bagnardi, Mariacristina Ghioni, Jamila Louahed, Vincent Brichard, Frederic F. Lehmann, Antonio Marra, Dario Trapani, Carmen Criscitiello, Giuseppe Viale   +9 more
doaj   +1 more source

An mRNA mix redirects dendritic cells towards an antiviral program, inducing anticancer cytotoxic stem cell and central memory CD8+ T cells

Frontiers in Immunology, 2023
Dendritic cell (DC)-maturation stimuli determine the potency of these antigen-presenting cells and, therefore, the quality of the T-cell response. Here we describe that the maturation of DCs via TriMix mRNA, encoding CD40 ligand, a constitutively active ...
Wout de Mey, Hanne Locy, Kirsten De Ridder, Phaedra De Schrijver, Dorien Autaers, Asma Lakdimi, Arthur Esprit, Lorenzo Franceschini, Kris Thielemans, Magali Verdonck, Karine Breckpot   +10 more
doaj   +1 more source

Emerging Roles of the Unique Molecular Chaperone Cosmc in the Regulation of Health and Disease

Biomolecules, 2022
The core-1 β1-3galactosyltransferase-specific chaperone 1 (Cosmc) is a unique molecular chaperone of core-1 β1-3galactosyltransferase(C1GALT1), which typically functions inside the endoplasmic reticulum (ER).
Ting Xiang, Muchuan Qiao, Jiangbo Xie, Zheng Li, Hailong Xie   +4 more
doaj   +1 more source

Expression of the Tn antigen on erythroid cells from a patient with Tn syndrome [PDF]

Japanese journal of human genetics, 1992
In order to examine expression of the Tn antigen on erythroid cells from a patient with Tn syndrome, we applied a selective two phase liquid culture system for human erythroid progenitors in peripheral blood. The cells were analyzed with flow cytometry employing an anti-Tn antibody and a lectin of Vicia villosa which recognizes only the Tn determinant.
Y, Kamitani, E, Kajii, T, Suda, S, Ikemoto   +3 more
openaire   +2 more sources

Demethylation of the Cosmc Promoter Alleviates the Progression of Breast Cancer Through Downregulation of the Tn and Sialyl-Tn Antigens [Retraction]

Cancer Management and Research, 2022
Xu F, Wang D, Cui J, Li J, Jiang H. Cancer Manag Res. 2020;12:1017–1027. At the authors request, the Editor and Publisher of Cancer Management and Research wish to retract the published article.
Xu F, Wang D, Cui J, Li J, Jiang H
doaj  

Fully synthetic Tn-based three-component cancer vaccine using covalently linked TLR4 ligand MPLA and iNKT cell agonist KRN-7000 as built-in adjuvant effectively protects mice from tumor development

Acta Pharmaceutica Sinica B, 2022
We present a new strategy for self-adjuvanting vaccine development that has different types of covalently-linked immunostimulants as the carrier molecule.
Deying Yang, Xiang Luo, Qinghai Lian, Lingqiang Gao, Chengxin Wang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Guochao Liao   +8 more
doaj   +1 more source

Targeting Tn-positive tumors with an afucosylated recombinant anti-Tn IgG

Scientific Reports, 2023
The aberrant expression of the Tn antigen (CD175) on surface glycoproteins of human carcinomas is associated with tumorigenesis, metastasis, and poor survival.
Yasuyuki Matsumoto, Nan Jia, Jamie Heimburg-Molinaro, Richard D. Cummings   +3 more
doaj   +1 more source

Shigella flexneri targets human colonic goblet cells by O antigen binding to Sialyl-Tn and Tn antigens via glycan-glycan interactions

, 2020
Shigella flexneri targets colonic cells in humans to initiate invasive infection processes that lead to dysentery, and direct interactions between their lipopolysaccharide O antigens and blood group A related glycans are involved in the cell adherence ...
Tran, ENH, Poole, J., Tran, E.N.H., Tse, E., Jennings, M.P., Morona, R, Poole, J, Tse, E, Day, C.J., McCartney, E., Day, CJ, Jennings, MP, McCartney, E, Morona, R.   +13 more
core   +1 more source

Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model

Journal for ImmunoTherapy of Cancer, 2023
Background Treatment of some blood cancers with T cells that express a chimeric antigen receptor (CAR) against CD19 have shown remarkable results. In contrast, CAR-T cell efficacy against solid tumors has been difficult to achieve.Methods To examine the ...
David M Kranz, Edward J Roy, Preeti Sharma, Diana Rose E Ranoa, Claire P Schane, Amber N Lewis, Edward Valdez, Venkata V V R Marada, Marlies V Hager, Will Montgomery, Steven P Wolf, Karin Schreiber, Hans Schreiber, Keith Bailey, Timothy M Fan, Paul J Hergenrother   +15 more
doaj   +1 more source