Results 71 to 80 of about 683,828 (283)

CD8+ T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2Kb-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection

Cell Reports, 2012
To study the CD8+ T cell response against a mouse γ-herpes virus, we generated Kb-MHV-68-ORF8604–612RAG−/− CD8+ T cell receptor transnuclear (TN) mice as a source of virus-specific CD8+ T cells.
Sharvan Sehrawat, Oktay Kirak, Paul-Albert Koenig, Marisa K. Isaacson, Sofia Marques, Gunes Bozkurt, J. Pedro Simas, Rudolph Jaenisch, Hidde L. Ploegh   +8 more
doaj   +1 more source

Identifizierung und funktionelle Charakterisierung von Glykomimetika für das Tn-Antigen [PDF]

, 2012
Das Tn-Antigen (CD 175) ist ein mit Serin oder Threonin O-glykosidisch verbundener N-Acetylgalaktosamin-Rest und stellt den ersten Schritt in der Biosynthese der GalNac-O-Glykane dar.
Bruhn, Sandra
core  

Short synthetic glycopeptides successfully induce antibody responses to carcinoma-associated Tn antigen.

, 2000
International audienceGlycopeptides containing a tumor-associated carbohydrate antigen (mono-, tri- or hexa-Tn antigen) as a B-cell epitope and a CD4+ T-cell epitope (PV: poliovirus or TT: tetanus toxin) were prepared for immunological studies.
Deriaud, E., Lo-Man, R., Bay, S., Cantacuzène, D., Nakada, H., Leclerc, C., Vichier-Guerre, S., D. Cantacuzène, S. Bay, S. Vichier-guerre, E. Deriaud, C. Leclerc, Leclerc, Céline, R. Lo-man, H. Nakada   +14 more
core   +1 more source

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

Advanced Science, EarlyView.
Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami, Sanad M. El‐Khatib, Suhas Sureshchandra, Elise Nguyen, Janaki Manoja Vinnakota, Robert Zeiser, Shivashankar Othy, Munjal M. Acharya   +7 more
wiley   +1 more source

Cosmc Disruption-Mediated Aberrant O-glycosylation Suppresses Breast Cancer Cell Growth via Impairment of CD44

Cancer Management and Research, 2020
Tan Du, 1,* Xingyuan Jia, 2,* Xichen Dong, 2 Xiaoli Ru, 3 Lina Li, 2 Yakun Wang, 2 Jian Liu, 2 Guosheng Feng, 1 Tao Wen 2 1Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China;
Du T, Jia X, Dong X, Ru X, Li L, Wang Y, Liu J, Feng G, Wen T   +8 more
doaj  

Mucin associated Tn and sialosyl-Tn antigen expression in colorectal polyps. [PDF]

Gut, 1992
Sialosyl-Tn antigen and its immediate precursor, Tn antigen, are carbohydrate structures associated with the earliest steps of mucin O-linked glycosylation. Both antigens have been shown previously to be highly sensitive and specific markers of colorectal cancer.
S H, Itzkowitz, E J, Bloom, T S, Lau, Y S, Kim   +3 more
openaire   +2 more sources

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source

Enhanced Immune Response Against the Thomsen-Friedenreich Tumor Antigen Using a Bivalent Entirely Carbohydrate Conjugate

Molecules, 2020
The Thomsen-Friedenreich (TF) antigen is a key target for the development of anticancer vaccines, and this ongoing challenge remains relevant due to the poor immunogenicity of the TF antigen.
Kristopher A. Kleski, Kevin R. Trabbic, Mengchao Shi, Jean-Paul Bourgault, Peter R. Andreana   +4 more
doaj   +1 more source

Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing. [PDF]

PLoS ONE, 2013
Membrane bound mucins are up-regulated and aberrantly glycosylated during malignant transformation in many cancer cells. This results in a negatively charged glycoprotein coat which may protect cancer cells from immune surveillance. However, only limited
Caroline B Madsen, Kirstine Lavrsen, Catharina Steentoft, Malene B Vester-Christensen, Henrik Clausen, Hans H Wandall, Anders Elm Pedersen   +6 more
doaj   +1 more source

Presence of the Tn antigen on hematopoietic progenitors from patients with the Tn syndrome. [PDF]

Journal of Clinical Investigation, 1985
The Tn syndrome is an acquired clonal disorder characterized by the exposure of a normally hidden determinant, the Tn antigen, on the surface of human erythrocytes, platelets, granulocytes, and lymphocytes. Two distinct populations, Tn positive (Tn+) and Tn negative (Tn-), of mature hemopoietic cells are present in Tn patients. To determine whether the
W, Vainchenker, G, Vinci, U, Testa, A, Henri, A, Tabilio, M P, Fache, H, Rochant, J P, Cartron   +7 more
openaire   +2 more sources