A Chemically Defined Four-Component Self-Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity. [PDF]
Adv Sci (Weinh)A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Ming W +9 more
europepmc +2 more sources
Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment
Biomedicines, 2022 Two granulysin (GRNLY) based immunotoxins were generated, one containing the scFv of the SM3 mAb (SM3GRNLY) and the other the scFv of the AR20.5 mAb (AR20.5GRNLY). These mAb recognize different amino acid sequences of aberrantly O-glycosylated MUC1, also
Patricia Guerrero-Ochoa +11 more
doaj +1 more source
Efficient and Reproducible Synthesis of an Fmoc-protected Tn Antigen [PDF]
, 2021 The total synthesis of the Thomsen-nouveau (Tn) antigen, a tumour-associated O-linked mucin glycopeptide, was achieved through a concise route. The key glycosylation step proved challenging to reproduce from the literature precedents and was most ...
John F., Trant +4 more
core +1 more source
Primary breast cancer tumours contain high amounts of IgA1 immunoglobulin: an immunohistochemical analysis of a possible carrier of the tumour-associated Tn antigen. [PDF]
PLoS ONE, 2013 The Tn antigen (GalNAc alpha-O-Ser/Thr) as defined by the binding of the lectin, helix pomatia agglutinin (HPA) or anti-Tn monoclonal antibodies, is known to be exposed in a majority of cancers, and it has also been shown to correlate positively with the
Charlotte Welinder +4 more
doaj +1 more source
Amplified Detection of Breast Cancer Autoantibodies Using MUC1-Based Tn Antigen Mimics [PDF]
, 2020 In many human carcinomas, mucin-1 (MUC1) is overexpressed and aberrantly glycosylated, resulting in the exposure of previously hidden antigens. This generates new patient antibody profiles that can be used in cancer diagnosis.
Hinou, Hiroshi [0000-0003-2223-7300] +7 more
core +1 more source
, 2023 In view of the simultaneous formation of Helix pomatia-specific, Tn/serologically A-like glycolipids with germline-encoded anti-Helix pomatia-, Tn/A cross- reactive IgM in the ovary of a healthy and fertile mouse, it is suggested that the mammalian ...
Peter Arend (560469)
core +1 more source
Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine
European Journal of Histochemistry, 2009 Tn, sialosyl-Tn and T antigens are simple mucintype carbohydrate antigens that may be expressed in human neoplasies due to alteration of the glycoprotein biosynthetic pathway.
M Grosso +4 more
doaj +3 more sources
Carbohydrate receptor-mediated gene transfer to human T leukaemic cells [PDF]
, 1994 The mucin-type carbohydrate Tn cryptantigen (GalNAcα1-O-Ser/Thr, where GalNAc is N-acetyl-D-galactosamine) is expressed in many carcinomas, in haemopoietic disorders including the Tn syndrome, and on human immunodeficiency virus (HIV) coat glycoproteins,
Berger, Eric G. +12 more
core +1 more source
Stem Cell Research & Therapy, 2023 Background Cosmc (C1GalT1C1) mutation could cause aberrant O-glycosylation and result in expression of Tn antigen on the surface of tumor cells (Tn+ cells), which is associated with the metastasis and prognosis of cancer progression.
Wen Hu +6 more
doaj +1 more source
Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics [PDF]
, 2018 N-Acetylgalactosamine (GalNAc) α-O-linked to l-threonine (Thr) (Tn antigen) and several mimics of this Tn antigen have been synthesized to explore the impact of the underlying amino acid in the presentation mode of the carbohydrate moiety. The structural
Alberto Avenoza (1470724) +35 more
core +1 more source