Results 141 to 150 of about 81,953 (280)
Calorimetric Analysis of the Interplay between Synthetic Tn Antigen-Presenting MUC1 Glycopeptides and Human Macrophage Galactose-Type Lectin. [PDF]
Biochemistry, 2021 Beckwith DM +9 more
europepmc +1 more source
British Journal of Haematology, EarlyView.Summary Diffuse large B‐cell lymphoma (DLBCL) type Richter transformation (DLBCL‐RT) in patients with chronic lymphocytic leukaemia (CLL) has a worse prognosis compared to de novo DLBCL (dnDLBCL). We investigated outcomes of patients with DLBCL‐RT with or without previous CLL‐directed therapy compared to dnDLBCL between 2002 and 2022.
Andreas Katsimigas +9 more
wiley +1 more source
Expression of Tn, sialosyl-Tn and T antigens in human foetal large intestine.
European journal of histochemistry : EJH, 2000 Tn, sialosyl-Tn and T antigens are simple mucin-type carbohydrate antigens that may be expressed in human neoplasies due to alteration of the glycoprotein biosynthetic pathway. Utilising specific monoclonal antibodies (HB-Tn1, HB-STn1 and HB-T1), we have investigated the expression of these simple mucin-type carbohydrate antigens in large intestine of ...
GROSSO, Maddalena +4 more
openaire +4 more sources
Intermediate clinical endpoints as surrogates for overall survival after salvage prostatectomy
BJU International, EarlyView.Objectives To evaluate biochemical recurrence‐free survival (BRFS) and metastasis‐free survival (MFS) as potential intermediate clinical endpoints (ICEs) for overall survival (OS) in patients undergoing salvage radical prostatectomy (sRP). Patients and Methods Evaluable patients were selected from a retrospective dataset, resulting in a cohort of 879 ...
Navid Roessler +22 more
wiley +1 more source
STHLM3 NorDCaP: prospective multicentre trial of Stockholm3 for active surveillance biopsy guidance
BJU International, EarlyView.Objectives Active surveillance (AS) is the preferred approach for low‐risk prostate cancer (PCa). Recent efforts have explored new biomarkers to reduce the frequency of surveillance biopsy. This study assessed Stockholm3 for predicting PCa upgrading during surveillance biopsies. Materials and Methods The prospective STHLM3‐AS NorDCaP trial included 199
Nicola Giudici +11 more
wiley +1 more source
The crystal structure of a plant lectin in complex with the Tn antigen.
, 2003 International audienceThe structure of the tetrameric Vicia villosa isolectin B4 (VVLB4) in complex with a cancer antigen, the Tn glycopeptide (GalNAc-O-Ser), was determined at 2.7 A resolution.
Bay, Sylvie +12 more
core +1 more source
Brain Pathology, EarlyView.Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen +8 more
wiley +1 more source
Towards the Synthesis of a C-glycoside Tn Antigen
Towards the Synthesis of a C-glycoside Tn Antigen Advait Desai, Iraj Sadraei, John F. Trant Many biological processes including bacterial and viral infections (notably HIV and the flu), immunogenic responses, and cancer pathogenesis/metastasis are ...
Desai, Advait
core
Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges
British Journal of Pharmacology, EarlyView.This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu +6 more
wiley +1 more source