Results 171 to 180 of about 80,546 (217)

Tn and Sialyl‐Tn antigens in canine gastric tissues

Veterinary and Comparative Oncology, 2020
AbstractMalignant transformation is often associated with abnormal protein glycosylation expressed, amongst others, by the accumulation of simple mucin‐type carbohydrates namely Tn and Sialyl‐Tn (STn) antigens. These are usually limited in normal tissues and their increased expression has been associated with cancer progression and poor prognosis. This
Ana R. Flores, Isabel Lemos, Alexandra Rema, Marian Taulescu, Fernanda Seixas, Celso A. Reis, Fátima. Gärtner, Irina Amorim   +7 more
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Expression of Tn and Sialyl-Tn Antigens in Tumor Tissues of the Ovary

American Journal of Clinical Pathology, 1991
The expression of sialyl-Tn and Tn antigens in various benign, borderline, and malignant ovarian tumors was examined immunohistochemically using newly developed antibodies specific for sialyl-Tn and Tn antigens. Sialyl-Tn antigen was detected in only one benign tumor, a mucinous adenoma that showed faint cytoplasmic staining in a few cells.
M, Inoue, S M, Ton, H, Ogawa, O, Tanizawa   +3 more
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Expression of Tn, sialosyl Tn, and T antigens in human pancreas

Gastroenterology, 1991
Carbohydrate antigens representing some of the initial steps in mucin O-linked glycosylation were examined in specimens of normal pancreas, chronic pancreatitis, and pancreatic adenocarcinoma. Tn antigen, recognized by Vicia villosa lectin, was expressed by all specimens of normal pancreas (acinar cells) and pancreatic cancers and all but one case of ...
S, Itzkowitz, T, Kjeldsen, A, Friera, S, Hakomori, U S, Yang, Y S, Kim   +5 more
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Coexpression of cancer-associated carbohydrate antigens, Tn and sialyl Tn

Glycoconjugate Journal, 1994
The expression of cancer-associated antigens, Tn and sialyl Tn, was examined using monoclonal antibodies, MLS 128 and MLS 102, recognizing these two antigens, respectively. A cell lysate from a human carcinoma cell line, LS 180 cells, was analysed by Western blotting using these two antibodies.
H, Nakada, M, Inoue, N, Tanaka, I, Yamashina   +3 more
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Tn‐activation with Acquired A‐like Antigen

Transfusion, 1972
The red blood cells of Mr. R. W., an 86‐year‐old type O patient with Proteus mirabilis wound infection, anemia, and thrombocytopenia were found to be polyagglutinable due to Tn‐activation, to be agglutinated by and to absorb anti‐A, and to have a reduced sialic acid level probably as a result of enzyme modification in vivo. The reaction with anti‐A was
H J, Berman, J, Smarto, C H, Issitt, P D, Issitt, W L, Marsh, L, Jensen   +5 more
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An Example of Polyagglutinability Due to the Tn Antigen

British Journal of Haematology, 1970
Summary. A case of atypical polyagglutinability due to the Tn antigen is described. The patient, although apparently healthy, has leucopenia and thrombocytopenia. Her cells presented the usual difficulties of polyagglutinable cells due to the presence of anti‐Tn in typing reagents whether of human or animal origin.
H H, Gunson, F, Stratton, G W, Mullard
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Rational design of a Tn antigen mimic

Chemical Communications, 2011
A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.
Corzana, Francisco, Busto, Jesús H., Marcelo, Filipa, García de Luis, Marisa, Asensio, Juan Luis, Martín-Santamaría, Sonsoles, Sáenz, Yolanda, Torres, Carmen, Jiménez-Barbero, Jesús, Avenoza, Alberto, Peregrina, Jesús M.   +10 more
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A monoclonal antibody directed to Tn antigen

Biochemical and Biophysical Research Communications, 1990
A murine monoclonal antibody, MLS 128, that was assigned to an anti-Tn antibody has been established by immunizing mice with human colonic cancer cells (LS 180). MLS 128 bound to mucin glycopeptides from LS 180 cells and their asialo forms to the same extent as well as to ovine submaxillary mucin (OSM) and asialo OSM.
Y, Numata, H, Nakada, S, Fukui, H, Kitagawa, K, Ozaki, M, Inoue, T, Kawasaki, I, Funakoshi, I, Yamashina   +8 more
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Expression of sialyl‐Tn, Tn and T antigens in primary liver cancer

Pathology International, 1999
Sialyl‐Tn, Tn and T antigens are caused by aberrant or incomplete glycosylation of apomucins and are related to the aggressiveness of malignant neoplasms. Using 41 liver samples from patients with cholangiocarcinoma (including four with cirrhosis), 21 with combined hepatocellular– cholangiocellular carcinoma and 17 with hepatocellular carcinoma, the ...
M, Sasaki, T, Yamato, Y, Nakanuma
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Enzymatic synthesis of the Tn antigen

Journal of Molecular Catalysis B: Enzymatic, 2007
The enzymatic synthesis of the Tn antigen (GalNAc--O-Ser), a glyco-aminoacid of great biological importance, is reported. The reaction was promoted by commercial -N-acetylgalactosaminidase from Acremonium sp., using p-nitrophenyl--N-acetylgalactosamine as the donor. The kinetics were monitored by capillary electrophoresis and LC–UV-MS.
COSLOVI, ANNA, Cristiana Campa, FLAMIGNI, ANNA, Marco Rossi, VETERE, AMEDEO, Fulvio Uggeri, PAOLETTI, SERGIO   +6 more
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