Results 71 to 80 of about 621,266 (288)
Cancer Management and Research, 2020 Tan Du, 1,* Xingyuan Jia, 2,* Xichen Dong, 2 Xiaoli Ru, 3 Lina Li, 2 Yakun Wang, 2 Jian Liu, 2 Guosheng Feng, 1 Tao Wen 2 1Department of Oncology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, People’s Republic of China;
Du T +8 more
doaj
, 1999 The idiopathic Tn-syndrome, formerly called ‘permanent mixed-field polyagglutinability’, is a rare hematological disorder characterized by the expression of the Tn-antigen on all blood cell lineages.
Berger, Eric G
core +1 more source
CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer
Advanced Science, EarlyView.Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano +10 more
wiley +1 more source
Molecules, 2020 The Thomsen-Friedenreich (TF) antigen is a key target for the development of anticancer vaccines, and this ongoing challenge remains relevant due to the poor immunogenicity of the TF antigen.
Kristopher A. Kleski +4 more
doaj +1 more source
Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing. [PDF]
PLoS ONE, 2013 Membrane bound mucins are up-regulated and aberrantly glycosylated during malignant transformation in many cancer cells. This results in a negatively charged glycoprotein coat which may protect cancer cells from immune surveillance. However, only limited
Caroline B Madsen +6 more
doaj +1 more source
Optimized Lipid Nanoparticles with Tail‐Modified Ionizable Lipids for Safer mRNA Delivery
Advanced Science, EarlyView.Systematic engineering of hydrophobic tail architecture in vitamin B5‐derived ionizable lipids establishes a comprehensive structure–activity relationship framework for mRNA delivery. Combined lipidtail and formulation optimization identifies TM1‐OPT3‐C, a lipid nanoparticle platform that improves efficacy–safety balance through efficient mRNA delivery,
Seo‐Hyeon Bae +27 more
wiley +1 more source
Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation
Advanced Science, EarlyView.Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan +11 more
wiley +1 more source
Cell Communication and Signaling, 2019 Background Ligands of the C-type lectin CLEC10A such as Tn and sialyl-Tn representing early intermediates of O-glycosylation are hallmarks of many human malignancies.
Anna-Katharina Kurze +7 more
doaj +1 more source
Different expression of Tn and sialyl-Tn antigens between normal and diseased human gastric epithelial cells. [PDF]
, 1998 Thomsen-Friedenreich antigen (T antigen) has been supposed to be a cancer-specific carbohydrate antigen. We have previously shown that one third of the Japanese population normally expressed T antigen in gastric surface epithelia and the other two thirds
Tsuji, Takao +4 more
core +1 more source