Results 181 to 190 of about 80,718 (256)

Microbiota–Neuroinflammation Crosstalk in Primary Brain Tumors: Focus on Glioblastoma

Brain and Behavior, Volume 16, Issue 8, August 2026.
Microbiota–neuroinflammation crosstalk in GBM. The schematic summarizes how gut microbiota and microbiota‐derived signals may influence GBM biology through gut–brain signaling, microbial metabolites, systemic immune modulation, BBB‐related pathways, tumor‐associated microbial signals, and immune‐metabolic changes within the GBM microenvironment.
Tareq Nayef AlRamadneh, Renuka Jyothi S, Priya Priyadarshini Nayak, Anima Nanda, Shaker Al Hasnaawei, Akanksha Bhatt, Ashish Singh Chauhan, Siya Singla, Mehrdad Nourizadeh   +8 more
wiley   +1 more source

A Phase I/II Study of Ibrutinib Plus Trastuzumab in HER2‐Positive Metastatic Breast Cancer

Cancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Ibrutinib has demonstrated inhibition of ErbB/HER tyrosine kinases in preclinical models. This Phase I/II study investigated the safety, efficacy, and immunomodulatory effects of ibrutinib in combination with trastuzumab in patients with HER2‐positive metastatic breast cancer (MBC) whose disease had progressed on ado‐trastuzumab emtansine ...
Joyce O'Shaughnessy, Andrea Glidden, Tracy Locke, Amy Scales, Elizabeth Gatewood, Jean‐Philippe Blanck, Jessica Castaneda‐Gill, Sharlin Patel, Yolanda D. Mahnke, Xuan Wang, Page Blas   +10 more
wiley   +1 more source

Humoral and cellular responses to SARS‐CoV‐2 variants after ancestral COVID‐19 vaccines in people with HIV and lung transplant recipients

Clinical &Translational Immunology, Volume 15, Issue 8, 2026.
This study compares the humoral and cellular immunogenicity of Dose 3 of Ancestral SARS‐CoV‐2 vaccine in participants with HIV and/or following lung transplantation with healthy controls. We highlight differences along a spectrum of immunocompromise, and the value of SARS‐CoV‐2 vaccination, even in the absence of detectable neutralisation responses ...
David WJ Griffin, Paul A Gill, Irene Boo, Shir Sun, Raffi Gugasyan, Alina Wang, Scott J Bornheimer, Stuart Turville, Anupriya Aggarwal, Greg I Snell, Glen P Westall, Emily SJ Edwards, Anna Coldham, Menno C van Zelm, Heidi E Drummer, James H McMahon   +15 more
wiley   +1 more source

Passenger variants as pan‐clonal markers of pediatric AML: Implications for molecular MRD

HemaSphere, Volume 10, Issue 8, August 2026.
Abstract A streamlined, sensitive, and universal molecular method for MRD detection in pediatric AML remains an unmet clinical need. Here, we propose a novel approach based on tracking somatic non‐coding passenger variants. Using whole‐genome sequencing (WGS) of diagnostic bone marrow DNA, we identify patient‐specific somatic passenger variants, which ...
Ruth Shiloh, Dana Dayan, Ifat Geron, Maor Cohen, Tamar Feuerstein, Jorge Cano‐Nistal, Nurit Gal‐Mark, Shlomit Barzilai‐Birenboim, Dafna Gaash, Michal Hameiri‐Grossman, Avraham Kahan, Jamal Mahajna, Nino Oniashvili, Hava Rosenfeld, Dan Scharf, Keren Shichrur, Elena Shinderman‐Maman, Sarah Elitzur, Yehudit Birger, Shai Izraeli, Yosef E. Maruvka   +20 more
wiley   +1 more source

Advancing Tumor Treatment Through Artificial Intelligence and Mathematical Modeling: A Comprehensive Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims Solid tumors emerge from uncontrolled cell division and interactions with neighboring cells that influence their growth and resistance to therapy. Anti‐cancer drugs are developed to disrupt these processes, but they often damage healthy cells, making treatment difficult to manage safely and effectively. As the global cancer
Mohsin Kamran, Abdul Majeed, A S M Rafiul Haque, Johari Yap Abdullah   +3 more
wiley   +1 more source

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Prevalence of Helicobacter pylori Infection in Children From Households With Members' History of Successful H. pylori Eradication

JGH Open, Volume 10, Issue 8, August 2026.
ABSTRACT Aims This study investigated the prevalence of Helicobacter pylori infection and associated factors in children from households with members' history of successful H. pylori eradication. Methods A cross‐sectional study was conducted from February to December 2024 in Hanoi, Vietnam.
Trang Dinh Linh, Van Hoang Thi Hai, Thuong Nguyen Thu, Uyen Vu Thi Thu, Trang Tran Thi Thu, Anh Le Quynh, Long Hoang Bao, Long Dao Van, Hang Dao Viet   +8 more
wiley   +1 more source

Control of naive T cell reactivity and peripheral tolerance by ascorbate and TET activity. [PDF]

Sci Adv
Hao X, Bai L, Li J, Xu B, Janke LJ, Palacios G, Guy C, Crawford JC, Fan Y, Rosikiewicz W, Keith J, Le H, He M, Yang D, Steele JA, Pruett-Miller SM, Cheng Y, Hanna JH, Geiger T, Feng Y.   +19 more
europepmc   +1 more source

Immune Effector Cell‐Associated Hematotoxicity With Secondary Myelofibrosis Following Idecabtagene‐Vicleucel for Multiple Myeloma, Comprehensively Treated With Autologous Hematopoietic Stem Cell Boosting

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Pancytopenia accompanied by chimeric antigen receptor T cell (CAR‐T) therapy is termed immune effector cell‐associated hematopoietic toxicity (ICAHT), which is often sustained and refractory to supportive care. We report a case of a 52‐year‐old man with multiple myeloma who developed severe ICAHT with secondary myelofibrosis (sMF) after ...
Keishi Ogura, Takahiro Fujino, Takahisa Nakamura, Akihiro Miyashita, Akio Onishi, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Shinichi Fuchida, Junya Kuroda   +9 more
wiley   +1 more source

MetF‐Dependent Methionine Biosynthesis Is Required for Mycobacterium tuberculosis Survival and In Vivo Persistence

MicrobiologyOpen, Volume 15, Issue 4, August 2026.
MetF is essential for both in vitro and in vivo growth of Mycobacterium tuberculosis, whereas MetE, previously considered essential in vitro, is dispensable in vivo. Given the importance of methionine and folate metabolism as drug targets, MetF represents a promising candidate, highlighting the need for in vivo validation.
Ikue Tosa, Tomoki Kitahara, Katsuki Takebe, Masaaki Nakayama, Yuko Ito, Akihito Nishiyama, Shintaro Seto, Hotaka Kawai, Hiharu Inoue, Yuki Fukada, Yuki Nishiya, Hitoshi Nagatsuka, Takayuki Wada, Manabu Ato, Sohkichi Matsumoto, Naoya Ohara   +15 more
wiley   +1 more source