Results 241 to 250 of about 551,022 (291)

Process Safety Assessment of the Iron-Catalyzed 1,2-<i>cis</i>-Selective Glycal Aminoglycosylation. [PDF]

Org Process Res Dev
Zhang D, Colombo N, Jiang Z, Pirola D, Nebuloni M, Xu H.   +5 more
europepmc   +1 more source

Glycopeptides incorporating sulfur-based Tn antigen mimics

, 2014
Compañón Pérez, Ismael, Corzana López, Francisco [0000-0001-5597-8127], Avenoza Aznar, Alberto [0000-0002-5465-3555], Gutiérrez Jiménez, Marta Isabel [0000-0003-1616-5216], Ayala, Miguel, Peregrina García, Jesús Manuel [0000-0003-3778-7065], Aydillo Miguel, Carlos [0000-0002-0542-967X], Rojas Cervellera, Víctor, Zurbano Asensio, María del Mar [0000-0001-6370-3537], Busto Sancirián, Jesús Héctor [0000-0003-4403-4790]   +9 more
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Rational design of a Tn antigen mimic [PDF]

Chemical Communications, 2011
A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.
Corzana, Francisco, Busto, Jesús H., Marcelo, Filipa, García de Luis, Marisa, Asensio, Juan Luis, Martín-Santamaría, Sonsoles, Sáenz, Yolanda, Torres, Carmen, Jiménez-Barbero, Jesús, Avenoza, Alberto, Peregrina, Jesús M.   +10 more
openaire   +4 more sources

Expression of the Tn antigen in myelodysplasia, lymphoma, and leukemia

Transfusion, 1992
Expression of the normally cryptic blood group antigen Tn has occasionally been reported in hematologic disease, but the true frequency of this change is not known. A mouse monoclonal antibody (FBT3) and immunohistochemistry were used to examine expression of the Tn antigen.
D J, Roxby, M B, Pfeiffer, A A, Morley, M A, Kirkland   +3 more
openaire   +3 more sources

Detection of Tn, sialyn-Tn and T antigens in HNPCC

, 1996
The simple mucin-type carbohydrate antigens Tn, sialosyl-Tn, T and the 'cryptic' sialylated variant of the last represent the mucin core oligosaccharide structures that are produced in the initial steps of the mucin biosynthetic pathway. Utilizing monoclonal antibodies anti-Tn antigen (HB-Tn1), anti-sialosyl-Tn antigen (HB-STn1), anti-T antigen (HB-T1)
G. GIUFFRÈ, E. VITARELLI, G. TUCCARI, PONZ DE LEON, Maurizio, G. BARRESI   +4 more
openaire   +2 more sources

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Tn and Sialyl‐Tn antigens in canine gastric tissues

Veterinary and Comparative Oncology, 2020
AbstractMalignant transformation is often associated with abnormal protein glycosylation expressed, amongst others, by the accumulation of simple mucin‐type carbohydrates namely Tn and Sialyl‐Tn (STn) antigens. These are usually limited in normal tissues and their increased expression has been associated with cancer progression and poor prognosis. This
Ana R. Flores, Isabel Lemos, Alexandra Rema, Marian Taulescu, Fernanda Seixas, Celso A. Reis, Fátima. Gärtner, Irina Amorim   +7 more
openaire   +2 more sources

Expression of Tn and Sialyl-Tn Antigens in Tumor Tissues of the Ovary

American Journal of Clinical Pathology, 1991
The expression of sialyl-Tn and Tn antigens in various benign, borderline, and malignant ovarian tumors was examined immunohistochemically using newly developed antibodies specific for sialyl-Tn and Tn antigens. Sialyl-Tn antigen was detected in only one benign tumor, a mucinous adenoma that showed faint cytoplasmic staining in a few cells.
M, Inoue, S M, Ton, H, Ogawa, O, Tanizawa   +3 more
openaire   +2 more sources

Expression of Tn, sialosyl Tn, and T antigens in human pancreas

Gastroenterology, 1991
Carbohydrate antigens representing some of the initial steps in mucin O-linked glycosylation were examined in specimens of normal pancreas, chronic pancreatitis, and pancreatic adenocarcinoma. Tn antigen, recognized by Vicia villosa lectin, was expressed by all specimens of normal pancreas (acinar cells) and pancreatic cancers and all but one case of ...
S, Itzkowitz, T, Kjeldsen, A, Friera, S, Hakomori, U S, Yang, Y S, Kim   +5 more
openaire   +2 more sources

Coexpression of cancer-associated carbohydrate antigens, Tn and sialyl Tn

Glycoconjugate Journal, 1994
The expression of cancer-associated antigens, Tn and sialyl Tn, was examined using monoclonal antibodies, MLS 128 and MLS 102, recognizing these two antigens, respectively. A cell lysate from a human carcinoma cell line, LS 180 cells, was analysed by Western blotting using these two antibodies.
H, Nakada, M, Inoue, N, Tanaka, I, Yamashina   +3 more
openaire   +2 more sources