Results 121 to 130 of about 83,060 (162)

An Example of Polyagglutinability Due to the Tn Antigen

British Journal of Haematology, 1970
Summary. A case of atypical polyagglutinability due to the Tn antigen is described. The patient, although apparently healthy, has leucopenia and thrombocytopenia. Her cells presented the usual difficulties of polyagglutinable cells due to the presence of anti‐Tn in typing reagents whether of human or animal origin.
H H, Gunson, F, Stratton, G W, Mullard
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Rational design of a Tn antigen mimic

Chemical Communications, 2011
A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.
Corzana, Francisco, Busto, Jesús H., Marcelo, Filipa, García de Luis, Marisa, Asensio, Juan Luis, Martín-Santamaría, Sonsoles, Sáenz, Yolanda, Torres, Carmen, Jiménez-Barbero, Jesús, Avenoza, Alberto, Peregrina, Jesús M.   +10 more
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Enzymatic synthesis of the Tn antigen

Journal of Molecular Catalysis B: Enzymatic, 2007
The enzymatic synthesis of the Tn antigen (GalNAc--O-Ser), a glyco-aminoacid of great biological importance, is reported. The reaction was promoted by commercial -N-acetylgalactosaminidase from Acremonium sp., using p-nitrophenyl--N-acetylgalactosamine as the donor. The kinetics were monitored by capillary electrophoresis and LC–UV-MS.
COSLOVI, ANNA, Cristiana Campa, FLAMIGNI, ANNA, Marco Rossi, VETERE, AMEDEO, Fulvio Uggeri, PAOLETTI, SERGIO   +6 more
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Expression of sialyl‐Tn, Tn and T antigens in primary liver cancer

Pathology International, 1999
Sialyl‐Tn, Tn and T antigens are caused by aberrant or incomplete glycosylation of apomucins and are related to the aggressiveness of malignant neoplasms. Using 41 liver samples from patients with cholangiocarcinoma (including four with cirrhosis), 21 with combined hepatocellular– cholangiocellular carcinoma and 17 with hepatocellular carcinoma, the ...
M, Sasaki, T, Yamato, Y, Nakanuma
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Tumor‐associated antigens: Tn antigen, sTn antigen, and T antigen

HLA, 2016
AbstractGlycosylation is one of the major posttranslational modifications of proteins. N‐glycosylation (Asn‐linked) and O‐glycosylation (Ser/Thr‐linked) are the two main forms. Abnormal O‐glycosylation is frequently observed on the surface of tumor cells, and is associated with an adverse outcome and poor prognosis in patients with cancer.
C, Fu, H, Zhao, Y, Wang, H, Cai, Y, Xiao, Y, Zeng, H, Chen   +6 more
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Expression of the Tn antigen in myelodysplasia, lymphoma, and leukemia

Transfusion, 1992
Expression of the normally cryptic blood group antigen Tn has occasionally been reported in hematologic disease, but the true frequency of this change is not known. A mouse monoclonal antibody (FBT3) and immunohistochemistry were used to examine expression of the Tn antigen.
D J, Roxby, M B, Pfeiffer, A A, Morley, M A, Kirkland   +3 more
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Detection of Tn, sialosyl-Tn and T antigens in hereditary nonpolyposis colorectal cancer

Virchows Archiv, 1996
The simple mucin-type carbohydrate antigens Tn, sialosyl-Tn, T and the 'cryptic' sialylated variant of the last represent the mucin core oligosaccharide structures that are produced in the initial steps of the mucin biosynthetic pathway. Utilizing monoclonal antibodies anti-Tn antigen (HB-Tn1), anti-sialosyl-Tn antigen (HB-STn1), anti-T antigen (HB-T1)
GIUFFRE', Giuseppe, VITARELLI E, TUCCARI, Giovanni, DELEON MP, BARRESI, Gaetano   +4 more
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Distribution of sialosyl Tn and Tn antigens within normal and malignant colorectal epithelium

The Journal of Pathology, 1995
AbstractExpression of the core blood group structures sialosyl Tn (STn) and Tn is regarded as a colorectal cancer‐specific change reflecting truncated synthesis of the oligosaccharide component of goblet cell mucin. The distribution of STn and Tn in normal and malignant epithelium has been studied in detail by a combination of mucin‐, lectin‐, and ...
J R, Jass, L J, Allison, S G, Edgar
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Detection of the Tn antigen in leukaemia using monoclonal anti‐Tn antibody and immunohistochemistry

British Journal of Haematology, 1987
SummaryExposure of the normally cryptic Tn antigen on haemopoietic cells leading to erythrocyte polyagglutination has been reported in a few cases of malignant or premalignant haemopoietic disorders and has been attributed to a selective deficiency of the enzyme 3–β‐D‐galactosyl‐transferase, A male patient presented with acute myelomonocytic leukaemia ...
D J, Roxby, A A, Morley, M, Burpee
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Tn and Sialyl-Tn Antigens as Potential Prognostic Markers in Human Ovarian Carcinoma

Gynecologic and Obstetric Investigation, 2010
Objective: Carcinoma-associated Tn and sialyl-Tn antigens have been shown to aid in the prediction of tumor aggressiveness. The purpose of this study was to evaluate the prognostic value of Tn and sialyl-Tn antigen expression in human ovarian carcinoma.
H, Ogawa, M, Ghazizadeh, T, Araki
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