Results 221 to 230 of about 621,266 (288)

T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy. [PDF]

Signal Transduct Target Ther
van den Broecke L, Van der Vreken A, Watté F, Meeus F, De Veirman K, Breckpot K, De Bruyne E, Menu E.   +7 more
europepmc   +1 more source

Tn Antigen-MUC1-32mer Antibody [PDF]

, 2020
openaire   +1 more source

Single‐Cell Transcriptome of Anaplastic Thyroid Cancer Reveals Immunosuppressive Tumor Microenvironment Remodeling

Cancer Medicine, Volume 15, Issue 9, September 2026.
Single‐cell RNA sequencing of anaplastic thyroid cancer (ATC) and aggressive papillary thyroid cancer (PTC) revealed coordinated tumor‐intrinsic and immune reprogramming during thyroid cancer dedifferentiation. ATC exhibited MAPK/PI3K co‐activation, p53 suppression, E2F activation, cytotoxic lymphocyte exhaustion, enhanced regulatory T‐cell ...
Saeko Tahara, Akiko Iguchi‐Manaka, Naoto Takeuchi, Tomohei Matsuo, Akira Shibuya, Kazuko Shibuya, Haruka Ozaki   +6 more
wiley   +1 more source

Linperlisib enhances MUC1-Tn CAR T cell efficacy by inhibiting EGR1/DUSP2 axis to prevent CAR T cell exhaustion. [PDF]

Leukemia
Wei JY, Liu ZW, Lu QS, Qin YJ, He YZ, Zheng YQ, Lin YC, Yang DH, Li YH, Huang YX.   +9 more
europepmc   +1 more source

Racial differences in multiple myeloma survival: Associations with stem cell transplantation, insurance, and Medicaid expansion

Cancer, Volume 132, Issue 17, 1 September 2026.
ABSTRACT Background At the population level, Black patients with multiple myeloma (MM) may experience worse survival than White patients. The authors examined how autologous stem cell transplantation (ASCT), insurance, and Medicaid expansion relate to racial differences in real‐world overall survival (rwOS). Methods Data from 4932 patients with MM (24%
F. Lennie Wong, Scott R. Goldsmith, Kimlin Ashing, Amrita Krishnan, Michael A. Rosenzweig, Saro H. Armenian   +5 more
wiley   +1 more source

Nailfold capillary phenotypes distinguish juvenile myositis subtypes and associate with disease activity

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Nailfold capillaroscopy is a non‐invasive imaging tool that can aid in the diagnosis and monitoring of juvenile myositis. Branched nailfold capillary morphology is more common in juvenile myositis patients, particularly those positive for TIF1γ+ autoantibodies. Juvenile myositis patients with more active disease demonstrate increased microhaemorrhages,
Nicholas McClellan, Li Chen, Sophia Matossian, Aurora Rynda, Kirsten Grant, Erin Janssen, J. Michelle Kahlenberg, Jessica L. Turnier   +7 more
wiley   +1 more source

Cosmc loss induces truncated O-glycosylation and accelerates Kras-driven pancreatic carcinogenesis. [PDF]

Neoplasia
Mercanoglu B, Schraps N, Giannou AD, Zhou J, Kind S, Reinecke M, Karstens KF, Dreyer B, Harder S, Zhang S, Papazoglou ED, Güngör C, Melling N, Schlüter H, Wagener C, Bockhorn M, Hackert T, Wolters-Eisfeld G.   +17 more
europepmc   +1 more source

Advances and challenges in immunotherapy for intrahepatic cholangiocarcinoma based on the tumour immune microenvironment

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
This review integrates ICC‐specific and broader BTC evidence to define how desmoplastic stroma, immune‐cell crosstalk, metabolic remodelling, and molecular heterogeneity shape immunotherapy response and resistance. It highlights biomarker‐guided, mechanism‐based combinations while emphasizing the limited maturity of ICC‐specific evidence for emerging ...
Mengyao Chen, Shuofan Jin, Yuxuan Zhou, Jinkai Tong, Yufan Zhao, Quanjun Yang   +5 more
wiley   +1 more source

3D ex vivo platform for high‐throughput immunotherapy screening in relapsed/refractory lymphoma patients

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Relapsed/refractory (R/R) B‐cell lymphomas (B‐NHL) remain incurable, with limited predictive biomarkers to guide immunotherapy. Preclinical platforms that faithfully preserve the immune context and the viability of patient samples are critically needed for relevant high‐throughput drug testing.
Fabien Gava, Paul Marcoux, Neus Serrat, Pauline Gravelle, Sonia Quertinmont, Marie Tosolini, Carla Faria, Juan G. Valero, Christina Schniederjohann, Cathy Quelen, Fanny Bouquet, Catia Fonseca, Sylvia Herter, Laura C. Deak, Ron McCord, Eugene Chiang, Peter‐Martin Bruch, Loïc Ysebaert, Patricia Pérez‐Galán, Camille Laurent, Christine Bezombes   +20 more
wiley   +1 more source