Results 191 to 200 of about 81,953 (280)

RNY1 Is Heterogeneously Partitioned in Inflamed Airway Fluid and Modulates Pro‐Inflammatory Macrophage Transcriptional Programming

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
Key Findings Summary: Extracellular RNY1 increases in airway fluid and correlates with levels of neutrophil infiltration in the lung during allergen‐induced inflammation. This YRNA is partitioned into both extracellular vesicle (EV)‐ and protein‐enriched airway fluid fractions and promotes transcriptional reprogramming of macrophages.
Cherie E. Saffold, Antiana C. Richardson, Heather H. Pua   +2 more
wiley   +1 more source

GATA3 Inhibits the Expression of Viral E6/E7 Genes, and Its Expression Is Compromised During HPV‐Mediated Cervical Carcinogenesis

Journal of Medical Virology, Volume 98, Issue 7, July 2026.
ABSTRACT High‐risk human papillomaviruses (HPV) are the main etiological agents of cervical cancer. The viral early promoter regulates the expression of E6/E7 oncoproteins, and its transcriptional activity is positively or negatively regulated by host transcription factors (TFs) that are able to bind to the viral long control region (LCR).
Valéria Talpe‐Nunes, Aline Lopes Ribeiro, Rafaella Almeida Nunes, João Simão Sobrinho, Amanda Schiersner Caodaglio, Rossana Veronica Mendonza Lopez, Thais Rocha, Maria Luiza Nogueira Dias Genta, Konstanze Schichl, Ademola Aiyenuro, John Doorbar, Laura Sichero   +11 more
wiley   +1 more source

Tn antigen promotes human colorectal cancer metastasis via H-Ras mediated epithelial-mesenchymal transition activation. [PDF]

J Cell Mol Med, 2019
Liu Z, Liu J, Dong X, Hu X, Jiang Y, Li L, Du T, Yang L, Wen T, An G, Feng G.   +10 more
europepmc   +1 more source

CD8+ Tissue‐Resident Memory T Cells in Health and Disease

MedComm, Volume 7, Issue 7, July 2026.
CD8+ TRM cells are at the center of immunity, mediating potent local innate and adaptive immune responses. While TRM cells mediate protective immunity against infections and tumors, they also contribute to pathological inflammation in autoimmune conditions.
Yu‐Han Ai, Ting‐Ting Xu, Sen Lin, Meng‐Yu Xiao, Yun‐Xia Lin, Hao‐Wen Ma, Yue‐Yang Liu, Yao‐Jie Wang, Lu‐Ning Yin, Mei Huang, Yong‐Da Liu, Chao Zhu, Xiao‐Ting Zhu, Ji‐Hang Yuan   +13 more
wiley   +1 more source

Specific Identification of Glycoproteins Bearing the Tn Antigen in Human Cells. [PDF]

Angew Chem Int Ed Engl, 2017
Zheng J, Xiao H, Wu R.
europepmc   +1 more source

Society for Maternal‐Fetal Medicine Statement: Evaluation and management of cell‐free DNA screening for fetal red cell antigen genotype in alloimmunized and non‐alloimmunized pregnancies

Pregnancy, Volume 2, Issue 4, July 2026.
Abstract A substantial portion of RhD‐negative pregnant patients carry an RhD‐negative fetus and are not at risk of RhD alloimmunization. Knowing the fetal RhD genotype allows such patients to avoid unnecessary monitoring or treatment. The use of cell‐free DNA (cfDNA) to detect the fetal RhD genotype from maternal blood has been proposed to identify ...
Society for Maternal‐Fetal Medicine (SMFM), Britton D. Rink, Jeffrey A. Kuller, Teresa N. Sparks, Malavika Prabhu, Anne H. Mardy, Lorraine Dugoff, Joseph R. Biggio, SMFM Publications Committee   +8 more
wiley   +1 more source

Machine‐learning prediction of affinity and epistasis in the bovine pancreatic trypsin inhibitor–chymotrypsin complex

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Protein–protein interactions (PPIs) are shaped by evolutionary pressures that fine‐tune binding affinities and drive the epistatic relationships that support functional outcomes. Here, we used the complex of bovine pancreatic trypsin inhibitor (BPTI) and chymotrypsin as a model system to study how mutations at one or two positions affect ...
Noam Tzuri, Itamar Kass, Yaron Orenstein, Niv Papo   +3 more
wiley   +1 more source

Optimizing Clinical Study Designs for CAR‐T Cell Therapy: Development of an Efficient Sampling Strategy Through Optimal Experimental Design

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 7, July 2026.
ABSTRACT CAR‐T cell therapy is a cellular cancer immunotherapy that has impressively improved outcomes in hematological malignancies compared to conventional treatments. Yet, many patients do not respond permanently. Nonlinear mixed‐effects modeling can support a better understanding of the unique and not fully understood dose‐exposure and exposure ...
Fenja Klima, Anna M. Mc Laughlin, Robin Michelet, Wilhelm Huisinga, Katy Haussmann, Annette Künkele, Andrew C. Hooker, Charlotte Kloft   +7 more
wiley   +1 more source

Sialyl-Tn Antigen Antibody [PDF]

, 2020
openaire   +1 more source

Early Phase Dose‐Finding Designs for CAR‐T Cell Therapies

Pharmaceutical Statistics, Volume 25, Issue 4, July/August 2026.
ABSTRACT Chimeric Antigen Receptor (CAR)‐T cell is an immunotherapy which revolutionised the treatment of relapsed/refractory lymphoma and leukaemia. It is shown to have a higher response rate, higher mid‐to‐long term overall survival, and lower toxicity than standard treatments.
Weishi Chen, Pavel Mozgunov, Jimmy Mullaert, Xavier Paoletti   +3 more
wiley   +1 more source