Results 201 to 210 of about 81,953 (280)

Risk of SARS‐CoV‐2 Infection and Hospitalisation in Immunocompromised Children: A Population‐Based Cohort Study in Italy and Norway

open access: yesActa Paediatrica, Volume 115, Issue 7, Page 1451-1460, July 2026.
ABSTRACT Aim Immunocompromised children (IC) were presumed to be at higher risk of SARS‐COV‐2 infection and severe COVID‐19, but population‐based evidence is limited. We assessed infection risk, COVID‐19 hospitalisation, and severe outcomes in IC compared with children with and without other high‐risk conditions.
Costanza Di Chiara   +13 more
wiley   +1 more source

Ph‐Negative Acute Lymphoblastic Leukemia in the Older Adults: Biology, Therapeutic Strategies and Unmet Needs

open access: yesEuropean Journal of Haematology, Volume 117, Issue 1, Page 24-41, July 2026.
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese   +12 more
wiley   +1 more source

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin‐1 in B Cells

open access: yesAnnals of the New York Academy of Sciences, Volume 1561, Issue 1, July 2026.
Ataxin‐1 has been recently implicated in B cell regulation in the context of multiple sclerosis pathology. In this study, we used a multiomics pipeline to profile the B cell transcriptome, epigenome, and proteome in response to encephalitogenic challenges.
Jonathan J. Carver   +6 more
wiley   +1 more source

Epigenetic silencing of the chaperone Cosmc in human leukocytes expressing tn antigen. [PDF]

open access: yesJ Biol Chem, 2012
Mi R   +12 more
europepmc   +1 more source

Immune dysregulation in mania: A proof‐of‐concept platelet proteomics study

open access: yesPsychiatry and Clinical Neurosciences, Volume 80, Issue 7, Page 575-584, July 2026.
Aims Bipolar disorder (BD) is a major psychiatric condition with a multifaceted and largely unknown pathophysiology. Mania, the defining feature of BD, remains underinvestigated. Proteomics offers a powerful, data‐driven, unbiased approach to uncover biological alterations.
Paola Magioncalda   +6 more
wiley   +1 more source

Strong Cross‐Reactivity of Anti–Plasmodium falciparum pLDH Monoclonal Antibodies With Plasmodium malariae pLDH in the Abbott Bioline Malaria Ag P.f/P.f/P.v Rapid Diagnostic Test

open access: yesTropical Medicine &International Health, Volume 31, Issue 7, Page 944-952, July 2026.
ABSTRACT Objectives This study aimed to describe the cross‐reactivity of the Abbott Bioline Malaria Ag P.f/P.f/P.v rapid diagnostic test, designed to detect Plasmodium falciparum and P. vivax , with other Plasmodium species, based on the detection of parasite lactate dehydrogenase enzymes.
Gabriel Montoia   +5 more
wiley   +1 more source

Transcriptomic Profiling of Diabetic Porcine Wound Healing Model Identifies Key Metabolic, Inflammatory, and Oxidative Stress Pathways

open access: yesWound Repair and Regeneration, Volume 34, Issue 4, July/August 2026.
ABSTRACT Diabetic foot ulcers remain a major clinical challenge as diabetes prevalence rises, emphasising the need for improved therapeutics and relevant preclinical models. Common rodent wound‐healing models poorly recapitulate human skin anatomy and repair.
Joshua T. McCune   +5 more
wiley   +1 more source

Cellular Dynamics of Transgenic Porcine Endothelial Cells to Inflammatory Stimuli in Xenotransplantation Settings

open access: yesXenotransplantation, Volume 33, Issue 4, July/August 2026.
ABSTRACT Inflammatory responses have been shown to contribute significantly to the rejection of grafts in both allo‐ and xenotransplantation. In particular, they play a pivotal role in promoting endothelial activation, complement deposition, and thrombosis, thereby compromising the graft function.
Mitra Gultom   +8 more
wiley   +1 more source

Polyphosphates Attenuate Interleukin‐12 Production in Macrophages Infected With Legionella pneumophila

open access: yesThe FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Legionella pneumophila infection leads to the release of pathogen‐associated molecular patterns, which recruits the adaptor protein MYD88, initiating both activating (e.g., NF‐κB) and inhibitory (e.g., PI3K/AKT) signaling pathways that regulate IL‐12 gene expression.
Kara Vasilew   +12 more
wiley   +1 more source

A cancer therapeutic vaccine based on clustered Tn-antigen mimetics induces strong antibody-mediated protective immunity. [PDF]

open access: yesAngew Chem Int Ed Engl, 2014
Richichi B   +7 more
europepmc   +1 more source

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