Application of Peptides Containing the Cleavage Sequence of Pro-TNFα in Assessing TACE Activity of Whole Cells [PDF]
Biological Chemistry, 2002 Tumor necrosis factor-α (TNFα) is presumably shed from cell membranes by TNFα-cleaving enzyme (TACE). The peptides SPLAQAVRSSSR and Dabcyl-LAQAVRSSSR-Edans, each encompassing the cleavage sequence of pro-TNFα recognized by TACE, were applied to intact ...
Becker, Bernhard F. +3 more
core +4 more sources
Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes. [PDF]
, 2014 Inflammatory response and cell death in hepatocytes are hallmarks of chronic liver disease, and, therefore, can be effective therapeutic targets. Neurotropin® (NTP) is a drug widely used in Japan and China to treat chronic pain.
Liang, Shuang +6 more
core +21 more sources
Renoprotective Potential of the Ultra-Pure Lipopolysaccharide from Rhodobacter Sphaeroides on Acutely Injured Kidneys in an Animal Model [PDF]
Archives of Razi Institute, 2021 One of the main causes of acute kidney injury is ischemic reperfusion injury (IRI). Inflammatory response, apoptotic damages, and oxidative stress-related injuries are all involved in the pathogenesis of IRI.
Munaf Aal-Aaboda +2 more
doaj +1 more source
Analysis of hematological parameters in rheumatoid arthritis patients receiving biological therapy
EXCLI Journal : Experimental and Clinical Sciences, 2022 Administration of biological therapy (BT) in rheumatoid arthritis (RA) patients is often associated with hematological complications, which result in switching among therapies.
Jana Pereckova +5 more
doaj +1 more source
Ankylosing spondylitis and multiple sclerosis: a surprising parallel [PDF]
Romanian Journal of Neurology, 2014 Ankylosing Spondylitis (AS) and Multiple Sclerosis (MS) are two different chronic autoimmune and inflammatory diseases, one rheumatic and the other one neurological, apparently without any connection between them.
Iulia Georgiana Stamate +3 more
doaj +1 more source
Biological Therapy During COVID-19
Вопросы современной педиатрии, 2020 There is crucial question on further therapeutic tactics for the management of such patients (within the severe epidemiological situation caused by the pandemic of new coronavirus SARS-CoV-2) due to widespread application of genetically engineered ...
Leyla S. Namazova-Baranova +2 more
doaj +1 more source
CDKI-73 Is a Novel Pharmacological Inhibitor of Rab11 Cargo Delivery and Innate Immune Secretion
Cells, 2020 Innate immunity is critical for host defence against pathogen and environmental challenge and this involves the production and secretion of immune mediators, such as antimicrobial peptides and pro-inflammatory cytokines.
Alexandra Sorvina +6 more
doaj +1 more source
Amyloid Beta, TNFα and FAIM-L; Approaching New Therapeutic Strategies for AD [PDF]
Frontiers in Neurology, 2014 ALZHEIMER’S DISEASE AND AMYLOID BETA Defining characteristics of Alzheimer’s disease (AD) are memory defects, synaptic alterations, presence of neuroinflammatory mediators, and a progressive neurodegeneration. One of the histopathological hallmarks of the disease is the presence of amyloid beta (Aβ) plaques; however, it seems that soluble oligomers ...
Carriba, Paulina, Comella, Joan X.
openaire +2 more sources
Effect of Lipopolysaccharide from Rhodobacter sphaeroides on Inflammatory Pathway and Oxidative Stress in Renal Ischemia/Reperfusion Injury in Male Rats [PDF]
Archives of Razi Institute, 2021 Ischemia/reperfusion injury (IRI) is caused by a sudden temporary impairment of the blood flow to the particular organ. The IRI of the kidneys is one of the main causes of acute kidney injury.
M Aal-Aaboda, A. R Abu Raghif, N. R Hadi
doaj +1 more source
Regulation of myogenic activation of p38 MAPK by TACE-mediated TNFα release [PDF]
Frontiers in Cell and Developmental Biology, 2014 The activation of p38 MAPK in myogenic precursor cells (MPCs) is a key signal for their exit of cell cycle and entry of the myogenic differentiation program. Therefore, identification of the signaling mechanism that activates p38 MAPK during this process is important for the understanding of the regulatory mechanism of muscle regeneration. This article
Li, Yi-Ping, Niu, Airu, Wen, Yefei
openaire +3 more sources