Results 91 to 100 of about 253,142 (331)

Animal‐Free Setup of a 3D Mature Adipocyte‐Macrophage Co‐Culture to Induce Inflammation In Vitro

Advanced Healthcare Materials, EarlyView.
A completely animal‐free 3D co‐culture is developed using human fat cells and immune cells. Animal‐based materials are replaced with gellan gum hydrogel and a serum‐free medium. Immune cells are effectively activated, producing specific inflammatory signals.
Sophia Nowakowski, Svenja Nellinger, Franziska Brigitte Albrecht, Petra Juliane Kluger   +3 more
wiley   +1 more source

Dysregulated homeostasis of acetylcholine levels in immune cells of RR-multiple sclerosis patients [PDF]

, 2016
Multiple sclerosis (MS) is characterized by pro-inflammatory cytokine production. Acetylcholine (ACh) contributes to the modulation of central and peripheral inflammation.
Biagioni, Stefano, Costantini, Erica, DI BARI, Maria, Di Nicola, Marta, D’Angelo, Chiara, Galizia, Sabrina, Gasperini, Claudio, Orlando, Viviana, Porfilio, Italo, Reale, Marcella, Ruggieri, Serena, Tata, Ada Maria   +11 more
core   +2 more sources

An Organ‐on‐Chip Platform for Strain‐Controlled, Tissue‐Specific Compression of Cartilage and Mineralized Osteochondral Interface to Study Mechanical Overloading in Osteoarthritis

Advanced Healthcare Materials, EarlyView.
A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi, Anastasiya Börsch, Paola Occhetta, Robert Ivanek, Martin Ehrbar, Lisa Krattiger, Philipp Oertle, Marko Loparic, Ivan Martin, Marco Rasponi, Andrea Barbero   +10 more
wiley   +1 more source

Diesel Exhaust Activates & Primes Microglia: Air Pollution, Neuroinflammation, & Regulation of Dopaminergic Neurotoxicity [PDF]

, 2011
BACKGROUND: Air pollution is linked to central nervous system disease, but the mechanisms responsible are poorly understood. OBJECTIVES: Here, we sought to address the brain-region-specific effects of diesel exhaust (DE) and key cellular mechanisms ...
Block, Michelle L, Duke, Laura, Johnson, Jo Anne, Kodavanti, Prasada, Kodavanti, Urmila, Levesque, Shannon, Lull, Melinda E., Stadler, Krisztian, Surace, Michael J., Taetzsch, Thomas, Wagner, Alison   +10 more
core   +1 more source

Novel immunostimulatory effects of osteoclasts and macrophages on human γδ T cells [PDF]

, 2014
25/10/2014 Acknowledgments The authors would like to acknowledge the Oliver Bird Foundation (RHE/00092/S1 24105) (A.P.) and Arthritis Research UK (18439) (K.T.) for funding this work, and to thank Dr Heather M.
Angela Pappalardo, Blink, Brandes, Brennan, Buchan, Chang, Coleman, Cui, Danks, Eidtmann, Feuillet, Fotin-Mleczek, Gao, Gnant, Grassi, Horwood, Horwood, Ito, Keith Thompson, Kenna, Keystone, Kiesel, Koch, Kong, Kunzmann, Lanca, Li, Li, Meliconi, Mitogawa, Miyagawa, Pappalardo, Peterman, Pollinger, Ribot, Roark, Robbie-Ryan, Roelofs, Roelofs, Romas, Sato, Sutton, Takayanagi, Taub, Thompson, Valcamonica, Wright, Yokota   +47 more
core   +2 more sources

Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells [PDF]

, 2020
BACKGROUND: In obstructive congenital hydrocephalus, cerebrospinal fluid accumulation is associated with high intracranial pressure and the presence of periventricular edema, ischemia/hypoxia, damage of the white matter, and glial reactions in the ...
Cifuentes, Manuel, Claros, Silvia, García-Bonilla, María, García-Martín, María L., Gutiérrez, Antonia, Jiménez, Antonio J., Jiménez, Sebastián, Muñoz-Hernández, M Carmen, Ojeda-Pérez, Betsaida, Páez-González, Patricia, Santos-Ruíz, Leonor, Shumilov, Kirill, Vitorica, Javier   +12 more
core   +2 more sources

Immunosuppressive Cytokine‐Tethered Hydrogel for Treating Rheumatoid Arthritis

Advanced Healthcare Materials, EarlyView.
An injectable hydrogel is developed by chemically tethering IL‐4, an immunosuppressive cytokine, to a hyaluronic acid‐based backbone. The hydrogel reduces joint friction and exerts immunomodulatory effects. In a rheumatoid arthritis (RA) mouse model, it reduced inflammation, preserved cartilage, and promoted anti‐inflammatory immune responses.
Woojin Back, Moonkyoung Jeong, Huyen‐Thao Le, Ji‐Ho Park   +3 more
wiley   +1 more source

Effect of Lactobacillus plantarum LS/07 in combination with flaxseed oil on the microflora, enzymatic activity, and histological changes in the development of chemically induced precancerous growth in the rat colon

Czech Journal of Animal Science, 2014
This experimental study showed the effect of L. plantarum LS/07 on the changes in total counts of coliform bacteria, enzymatic activities, cytokine and histological changes in the colonic mucosa, chemically induced by the application of 1.2 ...
L. Strojný, J. Štofilová, E. Hijová, V. Szabadosová, R. Salaj, I. Bertková, A. Chmelárová, D. Čokášová, B. Pramuková, A. Brandeburová, A. Bomba, N. Bobrov, P. Suchánek   +12 more
doaj   +1 more source

Exosome membrane bound TNF-receptor for the treatment of rheumatoid arthritis [PDF]

, 2017
Rheumatoid arthritis (RA) is an autoimmune disease that causes painful inflammation of the synovium of the patient’s joints. However, current treatments for RA have a variety of drawbacks.
Curley, Kevin, Duong, Natalie
core   +1 more source

Launching a Novel Preclinical Infrastructure: Comparative Oncology Trials Consortium Directed Therapeutic Targeting of TNFα to Cancer Vasculature

PLoS ONE, 2009
Under the direction and sponsorship of the National Cancer Institute, we report on the first pre-clinical trial of the Comparative Oncology Trials Consortium (COTC). The COTC is a novel infrastructure to integrate cancers that naturally develop in pet dogs into the development path of new human drugs.
Paoloni, Melissa C, Tandle, Anita, Mazcko, Christina, Hanna, Engy, Kachala, Stefan, LeBlanc, Amy, Newman, Shelley, Vail, David, Henry, Carolyn, Thamm, Douglass, Sorenmo, Karin, Hajitou, Amin, Pasqualini, Renata, Arap, Wadih, Khanna, Chand, Libutti, Steven K   +15 more
openaire   +7 more sources