Aggregate, EarlyView.Diabetic wound healing is blocked by persistent inflammation and oxidative stress. Bioactive substances like growth factors and Hsts promote repair but lack long‐term stability. Herein, a platelet membrane‐coated nanoparticle system (PNP) is proposed to achieve enhanced retention of aggregation‐induced emissive (AIE) molecular‐modified Hst1 (Hst1‐AIE ...
Xiaoxuan Lei +9 more
wiley +1 more source
Characterisation of receptor‐specific TNFα functions in adipocyte cell lines lacking type 1 and 2 TNF receptors [PDF]
, 2000 Jaswinder K. Sethi +5 more
openalex +1 more source
Aggregate, EarlyView.The selenium‐containing polyurethane (SePU) thermo‐sensitive hydrogel (SePU/HBC) was constructed by incorporating SePU into hydroxybutyl chitosan (HBC). This hydrogel alleviates endoplasmic reticulum stress (ERS) and inhibits cell apoptosis by activating the unfolded protein response (UPR), thereby promoting diabetic wound healing.
Mo Zhai +8 more
wiley +1 more source
Review article: the clinical role of anti‐TNFα antibody treatment in Crohn's disease [PDF]
, 2000 Bell, Kamm
openalex +1 more source
American Journal of Hematology, EarlyView.ABSTRACT The iron regulatory hormone hepcidin contributes to the pathogenesis of anemia of inflammation (AI) by inhibiting the iron exporter ferroportin in target cells, causing hypoferremia. Under acute inflammation, hepcidin induction requires hemojuvelin (Hjv), a bone morphogenetic protein co‐receptor, while Fpn mRNA is also suppressed in a hepcidin‐
Siqi Liu +3 more
wiley +1 more source
Azotemia, TNFα, and LPS prime the human neutrophil oxidative burst by distinct mechanisms
, 1996 Kenneth R. McLeish +4 more
openalex +1 more source
New Horizons for Multiple Sclerosis Therapy: 2025 and Beyond
Annals of Neurology, EarlyView.The advances achieved against multiple sclerosis (MS) represent one of the great success stories of modern molecular medicine. The development of therapies with increasing selectivity and safety, guided by gains in understanding the fundamental immunology, neurobiology, genetics, and triggers of this disease, have broadened the traditional focus on ...
Joseph J. Sabatino Jr. +2 more
wiley +1 more source
Expression of TNFα and TGFβ1 in Guillain–Barré syndrome: correlation of a low TNFα‐/TGFβ1‐mRNA ratio with good recovery and signs for immunoregulation within the cerebrospinal fluid compartment [PDF]
, 2000 L. M. Ossege +3 more
openalex +1 more source
Cationic Nanoparticles Mitigate Chemotherapy‐Induced Peripheral Neuropathy
Advanced NanoBiomed Research, EarlyView.Chemotherapy‐induced peripheral neuropathy (CIPN), caused by chemodrugs like paclitaxel (PTX), leads to severe neuropathic pain. This study evaluates PTX‐loaded PAMAM‐Chol nanoparticles (PTX‐NPs) to alleviate CIPN. PTX‐NPs achieve 99% drug‐loading efficiency, reduce neurotoxicity, and in murine models, decrease cold allodynia by 85% while restoring ...
Divya Bhansali +7 more
wiley +1 more source
Evidence for a JAK2/STAT3 proinflammatory and vasculogenic mimicry interrelated molecular signature in adipocyte-derived mesenchymal stromal/stem cells. [PDF]
Cell Commun SignalVeilleux C +4 more
europepmc +1 more source