Results 231 to 240 of about 254,881 (331)

β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis [PDF]

, 2001
Colin K. Combs, J. Colleen Karlo, Shih-Chu Kao, Gary E. Landreth   +3 more
openalex   +1 more source

Paradoxical Activation of Entheseal Myeloid Cells by JAK1 and Tyk2 Inhibitors via Interleukin‐10 Antagonism

Arthritis &Rheumatology, EarlyView.
Objective JAK inhibition (JAKi) is effective in seronegative spondyloarthropathy (SpA) spectrum disorders, but Tyk2 inhibition failed in SpA spectrum ulcerative colitis, and tofacitinib showed minimal benefit in Crohn disease, which highlights the complex role for JAK/STAT signaling in different inflammatory processes.
Sami Giryes, Chi Wong, Charlie Bridgewood, Mark Harland, Ala Altaie, Nicole McDermott, Kerem Abacar, Abhay Rao, Almas Khan, Tristan McMillan, Peter Loughenbury, Robert Dunsmuir, Vishal Borse, Tom Macleod, Dennis McGonagle   +14 more
wiley   +1 more source

Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases. [PDF]

MAbs
Yin T, Ramon A, Greenig M, Sormanni P, D'Adamio L.   +4 more
europepmc   +1 more source

Gout and NLRP3 Inflammasome Biology

Arthritis &Rheumatology, EarlyView.
This review describes the three broad stages of acute inflammation in the context of gout: initiation, leucocyte mobilization, and self‐resolution. A typical case of a gout flare is presented. The role of the NLRP3 inflammasome in acute monosodium urate crystal–induced inflammation is reviewed in detail.
Raewyn Poulsen, Nicola Dalbeth
wiley   +1 more source

Macrophage Transcriptomic Alterations Driven by Alphavirus-Based Cancer Immunotherapy Vectors. [PDF]

J Immunol Res
Korotkaja K, Lapina D, Rudevica Z, Zajakina A.   +3 more
europepmc   +1 more source

INTERACTIONS OF CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASES (CaMK) AND EXTRACELLULAR-REGULATED KINASE (ERK) IN MONOCYTE ADHERENCE AND TNFα PRODUCTION

, 2000
Matthew R. Rosengart, Saman Arbabi, Iris Garcia, Ronald V. Maier   +3 more
openalex   +1 more source

Dissociation of the Early Decline in Serum T3 Concentration and Serum IL-6 Rise and TNFα in Nonthyroidal Illness Syndrome Induced by Abdominal Surgery [PDF]

, 2001
Marina Michalaki, Apostolos G. Vagenakis, Maria Makri, Fotios Kalfarentzos, Venetsana Kyriazopoulou   +4 more
openalex   +1 more source

Regulatory Role of FGL‐1 in Interorgan Communication by Controlling T Cell Homeostasis During the Onset of Sjögren Disease

Arthritis &Rheumatology, EarlyView.
Objective Autoimmunity occurs due to the tactics between pathogenic and regulatory factors in systemic organs. Although interorgan communication has been demonstrated in various diseases, the effects of the crosstalk between the immune system and other organs on autoimmune disease is unknown.
Kunihiro Otsuka, Aya Ushio, Ruka Nagao, Shigefumi Matsuzawa, Rieko Arakaki, Kazuki Fukuta, Yasuhiro Mouri, Takaaki Tsunematsu, Naozumi Ishimaru   +8 more
wiley   +1 more source

Changes in Medical Management of Inflammatory Bowel Disease and Reducing Surgical Risk: Investigating Causality Through the Bradford-Hill Criteria. [PDF]

J Clin Med
Maggi D, Papi C, Festa S, Aratari A.
europepmc   +1 more source

Early detection of increased tumour necrosis factor alpha (TNFα) and soluble TNF receptor protein plasma levels after trauma reveals associations with the clinical course [PDF]

, 2001
S Spielmann, Thoralf Kerner, Olaf Ahlers, Didier Keh, Max Gerlach, Herwig Gerlach   +5 more
openalex   +1 more source