Results 241 to 250 of about 254,881 (331)

Mucosal‐associated invariant T cells in rheumatic diseases.

Arthritis &Rheumatology, Accepted Article.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor (TCR) and restriction by the MHC class I‐related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines. Upon activation, MAIT cells rapidly produce pro‐inflammatory cytokines,
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source

Short- and Long-Term Endothelial Inflammation Have Distinct Effects and Overlap with Signatures of Cellular Senescence. [PDF]

Cells
Belakova B, Basílio J, Campos-Medina M, Sommer AFP, Gielecińska A, Resch U, Schmid JA.   +6 more
europepmc   +1 more source

New treatment options in ankylosing spondylitis: a role for anti-TNFα therapy [PDF]

, 2001
Joachim Sieper, Jürgen Braun
openalex   +1 more source

Pharmacodynamic Effects of Litifilimab in Lupus in the LILAC Phase II Study: Rapid and Sustained Reductions in Type I Interferon‐Associated Gene Expression and Cytokines

Arthritis &Rheumatology, Accepted Article.
Objective The pharmacodynamic effects of litifilimab on type I interferon (IFN) response and correlations with clinical outcomes were investigated in systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). Methods Participants from Part A (SLE) or Part B (CLE with/without SLE) of the randomized phase II LILAC trial who received ...
Richard Furie, Victoria P. Werth, Eric Milliman, Kyle Ferber, Roland Brown, Jad Zoghbi, Nathalie Franchimont, Youmna Lahoud, Catherine Barbey   +8 more
wiley   +1 more source

Pathogenesis of nerve damage in leprosy: genetic polymorphism regulates the production of TNFα

, 2000
Euzenir Nunes Sarno, Adalberto Rezende Santos, Márcia Rodrigues Jardim, Philip Noël Suffys, Alexandre S. de Almeida, José A. C. Nery, Letícia Vieira, E P Sampaio   +7 more
openalex   +1 more source

Inhibition of Proteasome Activity Blocks the Ability of TNFα to Down-Regulate Gi Proteins and Stimulate Lipolysis [PDF]

, 2001
Leida Maria Botion, Allan R. Brasier, Bing Tian, Vidya Udupi, Allan Green   +4 more
openalex   +1 more source

Clonal sharing of CD8+ T‐cells links skin and joint inflammation in psoriatic arthritis

Arthritis &Rheumatology, Accepted Article.
Objective Psoriatic arthritis (PsA) is an HLA class I‐associated inflammatory arthritis that develops in up to 30% of people with psoriasis. We tested the hypothesis that skin and joint inflammation in PsA is linked in terms of CD8+ T‐cell phenotype and clonality.
Lucy E. Durham, Frances Humby, Nora Ng, Roman Laddach, Elizabeth H. Gray, Sarah E. Ryan, Kathryn J.A. Steel, Rosie Ross, Giovanni A. M. Povoleri, Rosamond Nuamah, Kathy Fung, Athul Menon Kallayil, Pawan Dhami, Bruce W. Kirkham, Leonie S. Taams   +14 more
wiley   +1 more source

Regarding "Effectiveness and Persistence of Anti-TNFα Treatment in Patients with Rheumatoid Arthritis - A 7 Years Real-World Cohort Study" [Letter]. [PDF]

Biologics
Borrás-Blasco J, Valcuende-Rosique A, Cornejo-Uixeda S.   +2 more
europepmc   +1 more source

Impact of TNFα, LTα, FcγRII and complement receptor on HIV-1 trapping in lymphoid tissue from HIV-infected patients

, 2000
Marlyse C. Knuchel, Roberto F. Speck, Erika Schlaepfer, Herbert Kuster, Peter Ott, Huldrych F. Günthard, Milos Opravil, Richard W. Cone, Rainer Weber   +8 more
openalex   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source