Results 281 to 290 of about 308,094 (362)

Chimeric antigen receptor cells as a tool for localized delivery of TNFα in solid cancer treatment. [PDF]

Hum Vaccin Immunother
Yao Z, Sittplangkoon C.
europepmc   +1 more source

Natural cutaneous anthrax infection, but not vaccination, induces a CD4(+) T cell response involving diverse cytokines. [PDF]

, 2015
Altmann, DM, Ascough, S, Baillie, L, Boyton, RJ, Doganay, M, Ingram, RJ, Maillere, B, Metan, G, Reynolds, CJ, Robinson, JH, Williamson, DE   +10 more
core   +1 more source

Blockade of TNFα to Improve Human CD34+ Cell Repopulating Activity in Allogeneic Stem Cell Transplantation [PDF]

, 2019
Vitalyi Senyuk, Pritesh Patel, Nadim Mahmud, Damiano Rondelli   +3 more
openalex   +1 more source

Pharmacokinetics, pharmacodynamics and safety of vutiglabridin after multiple oral administrations in healthy female and obese subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Vutiglabridin (HSG4112) is a novel drug under clinical development for antiobesity treatment. This study aimed to evaluate the pharmacokinetics (PKs) and safety of vutiglabridin after multiple oral administrations in healthy Korean female and obese subjects and explore short‐term pharmacodynamic (PD) responses.
Sooyoun Lee, Hyun Chul Kim, Young Ran Yoon, In‐Jin Jang, Sang‐Ku Yoo, Kyung‐Sang Yu   +5 more
wiley   +1 more source

A glucose kinase-independent HK2 activity prevents TNF-induced cell death by phosphorylating RIPK1. [PDF]

Nat Commun
Zou T, Liu R, Wang G, Wang G, Jiang Z, Wang C, Wang W, Cai M, Zhang S, Cao H, Zhang D, Wang X, Deng S, Li T, Gu J.   +14 more
europepmc   +1 more source

Epithelial EZH2 serves as an epigenetic determinant in experimental colitis by inhibiting TNFα-mediated inflammation and apoptosis

Proceedings of the National Academy of Sciences of the United States of America, 2017
Yongfeng Liu, Junjie Peng, Tongyu Sun, Ni Li, Le Zhang, Jiale Ren, Huairui Yuan, Shan Kan, Q. Pan, Xia Li, Yufeng Ding, M. Jiang, Xiaoji Cong, Minjia Tan, Yushui Ma, D. Fu, S. Cai, Yichuan Xiao, Xiaoming Wang, J. Qin   +19 more
semanticscholar   +1 more source

Safety, tolerability and pharmacokinetics of DNDI‐6148, a novel agent for leishmaniasis: A randomized, controlled, single ascending dose study in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim The benzoxaborole derivative DNDI‐6148 is an antiparasitic agent with activity against multiple Leishmania protozoan species, including L. infantum and L. donovani, which cause visceral leishmaniasis. We investigated the safety, tolerability and pharmacokinetics of single oral doses of DNDI‐6148 in a randomized, parallel‐group, placebo‐controlled ...
Jean‐Yves Gillon, Sophie Delhomme, Delphine Launay, Séverine Blesson, Stéphanie Braillard, Pegah Maghdooni, Frauke Assmus, Richard Hoglund, Joel Tarning, Sabrina Loyau, Byron Arana, Mathilde Latreille‐Barbier, Yves Donazzolo   +12 more
wiley   +1 more source

IFNγ and TNFα optimize salivary gland mesenchymal stromal cells: an alternative to marrow- and adipose-MSCs for radiation xerostomia. [PDF]

Regen Ther
Larsen MC, Gurevic I, Berube L, Vande Loo A, Hanson E, Adam R, Manfrè V, Parker M, Paz C, Galipeau J, Kimple RJ, Blitzer G, McCoy SS.   +12 more
europepmc   +1 more source

TNFα-stimulated gene-6 (TSG6) activates macrophage phenotype transition to prevent inflammatory lung injury

, 2016
Manish Mittal, Chinnaswamy Tiruppathì, Saroj Nepal, You‐Yang Zhao, Dagmara Grzych, Dheeraj Soni, Darwin J. Prockop, Asrar B. Malik   +7 more
openalex   +1 more source

Dynamic Immune Cell Composition, Phenotypes, and Signaling in an Engineered Metastatic Niche

Biotechnology and Bioengineering, EarlyView.
ABSTRACT In breast cancer patients, metastasis is the stage of disease where prognosis significantly worsens. However, the timing at which metastasis initiates and the location of metastatic lesions in an organ are stochastic, limiting the timely identification of disease and the administration of treatments.
Rebecca S. Pereles, Jyotirmoy Roy, Michael D. Brooks, Max S. Wicha, Jacqueline S. Jeruss, Lonnie D. Shea, Sophia M. Orbach   +6 more
wiley   +1 more source