Results 21 to 30 of about 308,094 (362)

Atherosusceptible Shear Stress Activates Endoplasmic Reticulum Stress to Promote Endothelial Inflammation. [PDF]

, 2017
Atherosclerosis impacts arteries where disturbed blood flow renders the endothelium susceptible to inflammation. Cytokine activation of endothelial cells (EC) upregulates VCAM-1 receptors that target monocyte recruitment to atherosusceptible regions ...
Bailey, Keith A, Haj, Fawaz G, Passerini, Anthony G, Simon, Scott I   +3 more
core   +1 more source

Low T cell production of TNFα and IFNγ in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism [PDF]

Annals of the Rheumatic Diseases, 2001
To test the hypothesis that ankylosing spondylitis (AS) is a T helper cell type 2 polarised disease by quantifying the T cell cytokines interferon gamma (IFNgamma), interleukin 4 (IL4), tumour necrosis factor alpha (TNFalpha), and IL10 at the single cell level in patients with AS in comparison with healthy HLA-B27 negative and HLA-B27 positive controls.
M, Rudwaleit, S, Siegert, Z, Yin, J, Eick, A, Thiel, A, Radbruch, J, Sieper, J, Braun   +7 more
openaire   +2 more sources

Microglia Responses to Pro-inflammatory Stimuli (LPS, IFNγ+TNFα) and Reprogramming by Resolving Cytokines (IL-4, IL-10)

Frontiers in Cellular Neuroscience, 2018
Microglia respond to CNS injuries and diseases with complex reactions, often called “activation.” A pro-inflammatory phenotype (also called classical or M1 activation) lies at one extreme of the reactivity spectrum.
S. Lively, L. Schlichter
semanticscholar   +1 more source

TNFα-Mediated Priming of Mesenchymal Stem Cells Enhances Their Neuroprotective Effect on Retinal Ganglion Cells

Investigative Ophthalmology and Visual Science, 2020
Purpose To determine whether priming of bone marrow mesenchymal stem cells (MSCs) by signals from injured retina, particularly tumor necrosis factor α (TNFα), increase their exosomes’ neuroprotective efficacy on retinal ganglion cells (RGCs).
B. Mead, Xitiz Chamling, D. Zack, Zubair Ahmed, S. Tomarev   +4 more
semanticscholar   +1 more source

Single-molecule imaging reveals the oligomeric state of functional TNFα-induced plasma membrane TNFR1 clusters in cells

Science Signaling, 2020
Ligand binding triggers the oligomerization of TNFR1 monomers and dimers into trimers and higher-order oligomers. Oligomerizing for optimal activity Drugs that prevent the activation of the TNFα receptor TNFR1 are of great interest because of the many ...
Christos Karathanasis, Juliane Medler, F. Fricke, Sonja Smith, Sebastian Malkusch, D. Widera, S. Fulda, H. Wajant, Sjoerd J. L. van Wijk, I. Dikič, M. Heilemann   +10 more
semanticscholar   +1 more source

The Role Activity of Complement, TNFα & IL12 in Pathogenesis Dengue Virus

Indonesian Journal of Tropical and Infectious Disease, 2010
Dengue Virus infection is always found in some part of the world especially South East Asia including Indonesia. The pathogenesis of Dengue Virus infection is still controversial.
Soegeng Soegijanto, Dian Dwi Sary, Budi Setiawan, Atsushi Yamanaka   +3 more
doaj   +1 more source

The Effects of Micronized Progesterone and Cabergoline On a Rat Autotransplantation Endometriosis Model: A Placebo Controlled Randomized Trial

Journal of Investigative Surgery, 2021
Aim The etiology of endometriosis is complex and various theories have been postulated. Endometriosis pathogenesis involves genetic susceptibility, immunologic alterations and inflammatory prerequisite pathways. In this pilot experimental animal study we
Tugba Karslıoglu, Ayse Filiz Gokmen Karasu, Pelin Yildiz   +2 more
doaj   +1 more source

PRAS40 suppresses atherogenesis through inhibition of mTORC1-dependent pro-inflammatory signaling in endothelial cells [PDF]

, 2019
Endothelial pro-inflammatory activation plays a pivotal role in atherosclerosis, and many pro-inflammatory and atherogenic signals converge upon mechanistic target of rapamycin (mTOR).
Althoff, Till F., Burghaus, Jana, Cao Ho, Thanh, Jürgensen, Lonny, Kamuf-Schenk, Verena, Katus, Hugo A., Kiper, Leon, Krull, Alexandros, Riechert, Eva, Schecker, Johannes, Stangl, Karl, Stangl, Verena, Völkers, Mirko, Wöltje, Kerstin, Zhang, Kevin Sun   +14 more
core   +1 more source

Obesity-Induced TNFα and IL-6 Signaling: The Missing Link between Obesity and Inflammation—Driven Liver and Colorectal Cancers

Cancers, 2018
Obesity promotes the development of numerous cancers, such as liver and colorectal cancers, which is at least partly due to obesity-induced, chronic, low-grade inflammation.
Lara Kern, Melanie J. Mittenbühler, A. J. Vesting, A. L. Ostermann, Claudia M. Wunderlich, F. Wunderlich   +5 more
semanticscholar   +1 more source

Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer

OncoImmunology, 2018
Head and neck squamous cell carcinomas (HNSCCs) frequently harbor genomic mutations in cell death pathways. Nearly 30% of HNSCCs overexpress Fas-Associated Death Domain (FADD), with or without BIRC2/3 genes encoding cellular Inhibitor of Apoptosis ...
Roy Xiao, Clint T. Allen, Linda Tran, Priya Patel, So-Jin Park, Zhong Chen, Carter Van Waes, Nicole C. Schmitt   +7 more
doaj   +1 more source