Results 21 to 30 of about 253,142 (331)

Regulation of NF-κB by PML and PML-RARα [PDF]

, 2017
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar, Carmody, Ruaidhri J., Chen, Youhai H., Keeshan, Karen, Lindsay, Andrew J., McCaffrey, Mary W., Mitxitorena, Izaskun, Pandolfi, Pier Paolo, Wan, Xiaochun   +8 more
core   +1 more source

TNFα induces Ca2+ influx to accelerate extrinsic apoptosis in hepatocellular carcinoma cells [PDF]

, 2018
BACKGROUND: Tumor necrosis factor-α has been proven an effective anticancer agent in preclinical studies. However, the translation of TNFα from research to clinic has been blocked by significant systemic toxicity and limited efficacy at maximal tolerated
Ji, Xiaoying, Jin, Mingpeng, Li, Deyang, Ren, Tingting, Wang, Jiaojiao, Wu, Yousheng, Xing, Jinliang, Yang, Hushan, Yin, Chun, Zhang, Hui, Zhu, Jianjun   +10 more
core   +4 more sources

Pivotal Role of Both TNF-α 238G/A and TCF7L2 C/T Gene Polymorphisms in Type 2 Diabetes

Open Access Macedonian Journal of Medical Sciences, 2020
Single nucleotide polymorphism (SNP) studies in the promoter region of tumor necrosis factor-alpha (TNF-α (238)) have suggested its role in increased insulin resistance and also in the progression from prediabetes to type 2 diabetes (T2DM). It has been reported that genetic variations in the promoter region regulate TNF-α production and transcription ...
Amel Mahmoud Kamal eldin, Yehia Z. Mahmoud, Amira Taha Zaki Ahmed, Hend Abdel-Ghany, Sahar H. El Hini, Eglal Ms. Hamed   +5 more
openaire   +4 more sources

Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer

OncoImmunology, 2018
Head and neck squamous cell carcinomas (HNSCCs) frequently harbor genomic mutations in cell death pathways. Nearly 30% of HNSCCs overexpress Fas-Associated Death Domain (FADD), with or without BIRC2/3 genes encoding cellular Inhibitor of Apoptosis ...
Roy Xiao, Clint T. Allen, Linda Tran, Priya Patel, So-Jin Park, Zhong Chen, Carter Van Waes, Nicole C. Schmitt   +7 more
doaj   +1 more source

EXPRESSION PATTERNS OF CHEMOKINE RECEPTORS CXCR3 AND CCR6, AND THEIR LIGANDS IN PERIPHERAL BLOOD OF PATIENTS WITH CHRONIC HEPATITIS C DURING ANTIVIRAL THERAPY USING PEGYLATED INTERFERONS

Медицинская иммунология, 2019
The work presents data on forty-one patients with chronic hepatitis C (HCV, genotype 1), at different liver fibrosis stages. The studies were performed in the course of interferon-containing treatment regimens, i.e., pegylated interferon combined with ...
V. V. Basina, N. A. Arsentieva, O. K. Batsunov, N. E. Lyubimova, A. V. Semenov, E. V. Esaulenko, Areg A. Totolian   +6 more
doaj   +1 more source

TNFα expressed on the surface of microparticles modulates endothelial cell fate in rheumatoid arthritis [PDF]

, 2018
Background: Rheumatoid arthritis (RA) is associated with a high prevalence of atherosclerosis. Recently increased levels of microparticles (MPs) have been reported in patients with RA.
Alessandri, Cristiano, Barbati, Cristiana, Ceccarelli, Fulvia, Colasanti, Tania, Conti, Fabrizio, Diociaiuti, Marco, Ferrigno, Sara, Finucci, Annacarla, Miranda, Francesca, Novelli, Lucia, Perricone, Carlo, Spinelli, Francesca Romana, Truglia, Simona, Valesini, Guido, Vomero, Marta   +14 more
core   +1 more source

DIAGNOSTIC AND PREDICTIVE VALUE OF TNF Α, IL-8 AND IL-6 ASSAYS IN THE PATIENTS WITH MYCOPLASMA-ASSOCIATED PNEUMONIAS

Медицинская иммунология, 2014
. We have observed 128 patients with non-nosocomial pneumonias. Bacterial microflora was isolated in 22.6 per cent of entire group. 17 per cent of the samples were seropositive for Mycoplasma pneumoniae, along with detectable DNA specific for this causal
T. I. Dolgikh, V. I. Sovalkin, I. V. Menshchikova   +2 more
doaj   +1 more source

Insulin mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by Rosiglitazone [PDF]

, 2005
Background: Obesity associated hypertension is likely to be due to multiple mechanisms. Identification of the renin-angiotensin system (RAS) within adipose tissue does, however, suggest a potential causal role for it in obesity-associated hypertension ...
Chetty, Rajkumar, Coppack, Simon, Harte, A. L. (Alison L.), Katz, Jonathan, Kumar, Sudhesh, McTernan, P. G. (Philip G.), Smith, Stephen   +6 more
core   +1 more source

TUMOR NECROSIS AND TRANSFORMING GROWTH FACTORS LEVEL IN SUB-CLINICAL STAGE OF CHRONIC HEPATITIS C

Медицинская иммунология, 2014
. Participation of pro- and anti-inflammatory cytokines in pathogenesis of inflammation and fibrosis served as a basis for studying TNFα and TGFβ levels in blood serum from the patients with chronic hepatitis C (CHC), as compared with modes and degree of
T. V. Antonova, N. L. Shironina, N. A. Gavrisheva, T. P. Ses   +3 more
doaj   +1 more source

Extracellular Vesicles from Hyperammonemic Rats Induce Neuroinflammation and Motor Incoordination in Control Rats

Cells, 2020
Minimal hepatic encephalopathy is associated with changes in the peripheral immune system which are transferred to the brain, leading to neuroinflammation and thus to cognitive and motor impairment. Mechanisms by which changes in the immune system induce
Paula Izquierdo-Altarejos, Andrea Cabrera-Pastor, Hernan Gonzalez-King, Carmina Montoliu, Vicente Felipo   +4 more
doaj   +1 more source