Results 301 to 310 of about 308,094 (362)

Histopathologic Analysis of the Morpho‐Functional Zones of the Human Acetabular Labrum

Clinical Anatomy, EarlyView.
ABSTRACT The structural and functional adaptation of soft tissues to mechanical load controls their ability to withstand injury and influences their capacity for healing. Similar to the knee meniscus, the acetabular labrum exhibits zonal differences in mechanical load distribution, resulting in distinct regions with unique structural and functional ...
Abdulaziz A. Alomiery, Andrew C. Hall, Thomas H. Gillingwater, Afaf Alsolami, Abduelmenem Alashkham   +4 more
wiley   +1 more source

Engineered anchoring aptamers induce relocalization and functional inactivation of transcription factors. [PDF]

Sci Adv
Ling N, Wu H, Zhang Y, Yao S, Liu F, Tang X, Xie T, Yuan Y, Wei X, Dai J, Chen W, Yan M, Wang Z, Peng T, Zhang Y, Wang H, Wu J, Ye M, Wu W.   +18 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB. [PDF]

PLoS One
Necker-Brown A, Mostafa MM, Georgescu A, Thorne AJ, Chandramohan P, Kooi C, Kalyanaraman K, Gao A, Bansal A, Sasse SK, Gerber AN, Leigh R, Newton R.   +12 more
europepmc   +1 more source

TIR-domain-containing protein C as modulator of innate immune checkpoints. [PDF]

Sci Rep
Heine L, Griffiths H, Hu H, Müller I, Kuhn S, Rudolph L, Rait X, Waldhuber A, Chen Y, Miethke T.   +9 more
europepmc   +1 more source

Healthcare costs of inflammatory bowel disease have shifted from hospitalisation and surgery towards anti-TNFα therapy: results from the COIN study

, 2012
Mirthe E. van der Valk, Marie‐Josée J. Mangen, Max Leenders, Gerard Dijkstra, Ad A. van Bodegraven, Herma H. Fidder, Dirk J. de Jong, Marieke Pierik, C. Janneke van der Woude, Mariëlle Romberg‐Camps, Cees H. Clemens, Jeroen M. Jansen, Nofel Mahmmod, Paul C. van de Meeberg, Andrea E. van der Meulen‐de Jong, Cyriel Y. Ponsioen, Clemens Bolwerk, J Vermeijden, Peter D. Siersema, Martijn GH van Oijen, Bas Oldenburg, on behalf of the COIN study group and the Dutch Initiative on Crohn and Colitis   +21 more
openalex   +2 more sources

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Hippo pathway suppression reprograms TNFα-primed glioblastoma extracellular vesicles transcripts cargo to drive mesenchymal stem/stromal cells vasculogenic mimicry. [PDF]

Cell Commun Signal
Zilinski R, Konan AS, Zgheib A, Eliopoulos N, Boudreau LH, Annabi B.   +5 more
europepmc   +1 more source

Supplementary Table 3 from Intracellular Osteopontin Promotes the Release of TNFα by Mast Cells to Restrain Neuroendocrine Prostate Cancer

Roberta Sulsenti, Giuseppina B. Scialpi, Barbara Frossi, Laura Botti, Renata Ferri, Irene Tripodi, Annamaria Piva, Sabina Sangaletti, Davide Pernici, Valeria Cancila, Francesco Romeo, Claudia Chiodoni, Daniele Lecis, Francesca Bianchi, Irene Fischetti, Claudia Enriquez, Filippo Crivelli, Marco Bregni, Giuseppe Renne, Salvatore Pece, Claudio Tripodo, Carlo Pucillo, Mario P. Colombo, Elena Jachetti   +23 more
openalex   +1 more source

Genomic and Immune Correlates of EZH2 Expression and Activity in Olfactory Neuroblastoma

Head &Neck, EarlyView.
ABSTRACT Purpose Olfactory neuroblastoma (ONB) is a rare sinonasal malignancy with limited therapeutic options in the recurrent/metastatic setting; little is known regarding its responsiveness to immunotherapy. Inhibition of enhancer of zeste homolog 2 (EZH2) has been shown to improve T‐cell‐mediated killing and susceptibility to immune checkpoint ...
Elisabetta Xue, Tolulope Adeyelu, Harris Krause, Andrew Elliott, Ranee Mehra, Heloisa Soares, Emil Lou, Ari Vanderwalde, David Spetzler, Dara Bracken‐Clarke, Nyall R. London Jr., James L. Gulley, Charalampos S. Floudas   +12 more
wiley   +1 more source