Results 331 to 340 of about 308,094 (362)

Signatures of Trained Immunity Following mRNA Vaccination: Differences Between mRNA-1273 and BNT162b2. [PDF]

J Clin Immunol
Kunc M, Whitehead BJ, Østergaard LJ, Tolstrup M, Benn CS, Wejse CM, Nejsum P.   +6 more
europepmc   +1 more source

GERD and Upper Aerodigestive Tract Cancer Risk: A Systematic Review and Meta‐Analysis

The Laryngoscope, EarlyView.
ABSTRACT Objective Gastroesophageal reflux disease (GERD) is highly prevalent, yet its association with upper aerodigestive tract (UADT) cancers beyond esophageal adenocarcinoma remains incompletely defined. This systematic review and meta‐analysis aimed to quantify the risk of specific UADT cancers in individuals with GERD.
Janice Huang, Nicolas Jo, Garret Forman, Tonya Aaron, Sophia Peifer, Soumil Prasad, Luke van Leeuwen, Laura Wild, Nicholas DiStefano, Zhibin Chen, Elizabeth Franzmann   +10 more
wiley   +1 more source

Pharmacological characterization and preclinical evaluation of 11h: a novel, brain-penetrant PDE4 inhibitor for neurological disorders. [PDF]

Front Pharmacol
Lackovic J, Dey S, Ward SJ, Greig NH, Tweedie D, Beiranvand N, Saini U, Chatterjee D, Varadhachary A.   +8 more
europepmc   +1 more source

Circadian Immunity and Vascular Inflammation in Cardiovascular Disease Chronotherapy Windows: Time for a Re‐Assessment

Med Research, EarlyView.
ABSTRACT Circadian rhythms orchestrate cardiovascular physiology by regulating immune and inflammatory pathways. Disruption of these rhythms profoundly alters vascular homeostasis, thereby promoting the onset and progression of cardiovascular diseases (CVD).
Tian Zhang, Ge Zhang, Tian‐Ding Liu, Tianshu Gu, Fengyi Yu, Pengyuan Xu, Wunan Mi, Xuanjiang Zhao, Qian Guo, Honglin Zheng, Taiqi Zhao, Qiang Li, Di Lu, Mingxuan Duan, Chaoyang Yu, Ruhao Wu, Shiqian Zhang, Haonan Zhang, Zeyu Wang, Youyang Zheng, Yan Xiao, Zenglei Zhang, Ge Zhang   +22 more
wiley   +1 more source

A novel composite biomarker score for the identification of cognitive impairment in patients with heart failure: a pilot study. [PDF]

Biomarkers
Hoyer-Kimura C, Palmer J, Gopalan R, Doyle K, Frye J, Juneman E, Irwin K, Galdamez-Avila A, Carrillo K, Lizzette Cruz S, Schrag C, Oskouie S, Kalya A, Bedoya A, Konhilas JP, Ashton NJ, Ryan L, Sweitzer NK, Hay M.   +18 more
europepmc   +1 more source

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

The Journal of Pathology, EarlyView.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis, Georgia Sotiropoulou   +3 more
wiley   +1 more source

IL-1β, TNF-α, and IL-10 reduce cell viability and differentially alter biofilm structure and gene expression levels in <i>Staphylococcus aureus</i> USA 300. [PDF]

Front Immunol
Zavala-Hernández AN, Salto-Reyes C, Bravo-Patiño A, Baizabal-Aguirre VM, Valdez-Alarcón JJ.   +4 more
europepmc   +1 more source

Uncoupling TGFβ1 signalling from collagen protein synthesis in Dupuytren's disease

The Journal of Pathology, EarlyView.
Abstract Dupuytren's disease is a fibroproliferative disorder of the palmer fascia (PF) characterised by flexion contractures in the hand. Dupuytren's disease can be treated surgically, but disease recurrence rates are high, potentially due to continual production of matrisomal proteins.
Gabriella Cooper, Jade A Gumbs, Sahem Alkharabsheh, Katie J Lee, Alan Carter, Hannah Coleman, Niamh S O'Heneghan‐Yates, Rama Ijaz, Emma Beamish, Lisa A Menezes, Triantafillos Liloglou, Peter D Clegg, Elizabeth G. Canty‐Laird   +12 more
wiley   +1 more source

Eltrombopag olamine induces apoptosis in human breast adenocarcinoma and hepatocellular carcinoma cells through modulation of multiple apoptotic pathways. [PDF]

Sci Rep
Kabir SR, Asaduzzaman M, Shahinuzzaman ADA, Alam MT.   +3 more
europepmc   +1 more source

Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases

Rare Metals, EarlyView.
ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan, Shengjie Xue, Junyi Yin, Shaolei Wang, Yunlei Zhou, Jieyue Liao   +5 more
wiley   +1 more source