Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFα-induced MEK/ERK signalling [PDF]
Arthritis Research & Therapy, 2009 Abstract Introduction TNFα is increased in the synovial fluid of patients with rheumatoid arthritis and osteoarthritis. TNFα activates mitogen-activated kinase kinase (MEK)/extracellular regulated kinase (ERK) in chondrocytes; however, the overall functional relevance of MEK/ERK to TNFα-regulated gene ...
Rockel, Jason S. +2 more
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Anthocyanins inhibit tumor necrosis alpha-induced loss of Caco-2 cell barrier integrity [PDF]
, 2017 An increased permeability of the intestinal barrier is proposed as a major event in the pathophysiology of conditions characterized by chronic gut inflammation.
Anderson, Maureen +8 more
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Continuous low-intensity ultrasound attenuates IL-6 and TNFα-induced catabolic effects and repairs chondral fissures in bovine osteochondral explants [PDF]
BMC Musculoskeletal Disorders, 2019 Cartilage repair outcomes are compromised in a pro-inflammatory environment; therefore, the mitigation of pro-inflammatory responses is beneficial. Treatment with continuous low-intensity ultrasound (cLIUS) at the resonant frequency of 5 MHz is proposed for the repair of chondral fissures under pro-inflammatory conditions.Bovine osteochondral explants,
Sahu, Neety +2 more
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Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells [PDF]
, 2014 The roles of CYP lipid-metabolizing pathways in endothelial cells are poorly understood. Human endothelial cells expressed CYP2J2 and soluble epoxide hydrolase (sEH) mRNA and protein.
Ara A. Askari +35 more
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TNFα inhibitors exacerbateMycobacterium paratuberculosisinfection in tissue culture: a rationale for poor response of patients with Crohn’s disease to current approved therapy [PDF]
BMJ Open Gastroenterology, 2018 BackgroundThe role ofMycobacteriumaviumsubspeciesparatuberculosis(MAP) in Crohn’s disease (CD) is increasingly accepted as evident by detection of the bacteria in the blood and intestinal tissue from patients with CD, and by supporting data from several open-label anti-MAP treatment studies.
Qasem, Ahmad, Naser, Saleh A.
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Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
The response of cytokines and stress hormones to one session of intensive aerobic exercise in cold environment in active women [PDF]
فیزیولوژی ورزش و فعالیت بدنی, 2010 The response of cytokines and stress hormones to one session of intensiveaerobic exercise in cold environment in active womenAbstractThere are many hormones interaction between immune and nervous systems which are common insome messenger molecules as ...
مژگان احمدی +3 more
doaj +1 more source
Persistence of the immune response induced by BCG vaccination. [PDF]
, 2008 BACKGROUND: Although BCG vaccination is recommended in most countries of the world, little is known of the persistence of BCG-induced immune responses. As novel TB vaccines may be given to boost the immunity induced by neonatal BCG vaccination, evidence ...
Anne Ben-Smith +30 more
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Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma [PDF]
Cell Death & Disease, 2013 Neuroinflammation is a common feature of acute neurological conditions such as stroke and spinal cord injury, as well as neurodegenerative conditions such as Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. Previous studies have demonstrated that acute neuroinflammation can adversely affect the survival of neural precursor ...
Guadagno, J. +4 more
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