Results 51 to 60 of about 308,094 (362)

CCR2-Dependent Recruitment of Tregs and Monocytes Following Radiotherapy Is Associated with TNFα-Mediated Resistance

Cancer immunology research, 2019
Local radiation therapy of head and neck squamous cell carcinoma tumors induces distinct CCR2-dependent waves of Treg and TNFα-producing monocyte infiltration.
M. Mondini, Pierre-Louis Loyher, Pauline Hamon, M. Gerbé De Thoré, Marie Laviron, K. Berthelot, C. Clémenson, B. Salomon, C. Combadière, E. Deutsch, A. Boissonnas   +10 more
semanticscholar   +1 more source

Efektivitas Ekstrak Daun Sirsak (Annona Muricata) dalam Menurunkan Kadar TNFα dan Meningkatkan Kadar NO Uji Coba pada Mencit Swiss yang Diinokulasi Plasmodium Berghei

Jurnal Kedokteran Brawijaya, 2016
Ekstrak daun sirsak (Annona muricata) mengandung antioksidan seperti flavanoid, acetogenins yang memiliki peran sebagai antiplasmodium secara in vitro. Penelitian ini bertujuan menguji pengaruh ekstrak etanol daun sirsak terhadap penurunan kadar Tumor Necrosis Fakctor-alpha (TNFα) dan peningkatan kadar Nitric Oxide (NO) pada limpa mencit Swiss betina ...
Maria Estela K, Fransisca Prameshinta H, Edi Dharmana, RA Kisdjamiatun   +3 more
openaire   +1 more source

Imbalance of the “ligandreceptor” tumor necrosis factor αsystem and TNFRI expression in thyroid tissue in patients with Graves' disease

Клиническая и экспериментальная тиреоидология, 2013
The aim of the study was to examine the system of tumor necrosis factor α(TNFα), depending on the functional and morphological outcome of Graves’ disease (GD).

doaj   +1 more source

Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. [PDF]

, 2015
BackgroundParkinson's disease (PD) is one of the most common causes of dementia and motor deficits in the elderly. PD is characterized by the abnormal accumulation of the synaptic protein alpha-synuclein (α-syn) and degeneration of dopaminergic neurons ...
Anderson, Scott, Mante, Michael, Masliah, Eliezer, Rockenstein, Edward, Valera, Elvira   +4 more
core   +2 more sources

NF-κB signaling and crosstalk during carcinogenesis

4 open, 2019
Transcription factors (TFs) are proteins that control the transcription of genetic information from DNA to mRNA by binding to specific DNA sequences either on their own or with other proteins as a complex.
Brücher Björn L.D.M., Lang Florian, Jamall Ijaz S.   +2 more
doaj   +1 more source

Ultraviolet Radiation Effects on Human Keratinocyte ICAM-1 Expression: UV-Induced Inhibition of Cytokine-Induced ICAM-1 mRNA Expression Is Transient, Differentially Restored for IFNγ Versus TNFα, and Followed by ICAM-1 Induction Via a TNFα-Like Pathway

Journal of Investigative Dermatology, 1992
Human keratinocytes (KC) during the course of inflammatory dermatoses strongly express the surface molecule ICAM-1, which plays an important role in the generation of the epidermal inflammatory infiltrate by mediating leukocyte-keratinocyte interactions.
Krutmann, Jean, Czech, Wolfgang, Parlow, Frauke, Trefzer, Uwe, Kapp, Alexander, Schöpf, Erwin, Luger, Thomas A   +6 more
openaire   +2 more sources

Cell-centred meta-analysis reveals baseline predictors of anti-TNFα non-response in biopsy and blood of patients with IBD

Gut, 2018
Objective Although anti-tumour necrosis factor alpha (anti-TNFα) therapies represent a major breakthrough in IBD therapy, their cost–benefit ratio is hampered by an overall 30% non-response rate, adverse side effects and high costs.
Renaud Gaujoux, E. Starosvetsky, Na'ama Maimon, Francesco Vallania, H. Bar-Yoseph, S. Pressman, R. Weisshof, I. Goren, K. Rabinowitz, M. Waterman, H. Yanai, I. Dotan, E. Sabo, Y. Chowers, P. Khatri, S. Shen-Orr   +15 more
semanticscholar   +1 more source

Cytotoxic polyfunctionality maturation of cytomegalovirus-pp65-specific CD4 + and CD8 + T-cell responses in older adults positively correlates with response size [PDF]

, 2016
Cytomegalovirus (CMV) infection is one of the most common persistent viral infections in humans worldwide and is epidemiologically associated with many adverse health consequences during aging.
A Harari, A Lelic, AM Simanek, AR Hersperger, AW Sylwester, C Courivaud, C Riou, E Derhovanessian, E Gimenez, E Sinclair, EJ Wherry, ET Roberts, F Bihl, F Kern, F Sallusto, G Makedonas, G Makedonas, G Pawelec, G Pawelec, GC Wang, GC Wang, IG Rodrigue-Gervais, J Cheng, J van Zanten, JM Fletcher, L Cicin-Sain, L Cicin-Sain, L Krol, ML Pita-Lopez, MR Betts, MR Wills, N Khan, P Trzonkowski, PA Darrah, Q Ouyang, R Lachmann, R Solana, R Vescovini, RA Seder, RA van Lier, S Cantisan, SA Migueles, SH Park, SR Hadrup, T Crough, V Appay, YL Chiu, YN Ji   +47 more
core   +1 more source

IMMUNOLOGICAL STATUS OF PATIENTS WITH TUBERCULOSIS

Инфекция и иммунитет, 2015
In 46 patients with active pulmonary tuberculosis who were treated in 2014, the features of the immunological status by defining standard immunograms and serum levels of TNFα, IL-1β, IL-10, as well as autoantibodies to collagen I and III type have been ...
L. G. Tarasova, E. N. Strel’tsova
doaj   +1 more source

By protecting against cutaneous inflammation, epidermal pigmentation provided an additional advantage for ancestral humans. [PDF]

, 2019
Pigmentation evolved in ancestral humans to protect against toxic, ultraviolet B irradiation, but the question remains: "what is being protected?" Because humans with dark pigmentation display a suite of superior epidermal functions in comparison with ...
Abuabara, Katrina, Elias, Peter M, Lee, Chih-Hung, Lin, Tzu-Kai, Man, Mao-Qiang, Sheu, Hamm-Ming, Tsai, Jui-Chen, Wakefield, Joan S   +7 more
core   +1 more source