TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma
Nature Communications, 2017 Antibodies against programmed cell death-1 (PD-1) have considerably changed the treatment for melanoma. However, many patients do not display therapeutic response or eventually relapse.
Florie Bertrand +11 more
semanticscholar +1 more source
Role of TNFα and IL-10 in rheumatoid arthritis and association with some HLA II DR and DQ alleles
Медицинская иммунология, 2020 Rheumatoid arthritis (RA) is a systemic disease that causes progressive joint damage and disability. The affected tissues are histologicaly characterized by prominent infiltration with inflammatory mononuclear cells, such as T cells and macrophages, and ...
N. Alsalih, S. S Raheem, A. Alyasari
doaj +1 more source
Dysregulated homeostasis of acetylcholine levels in immune cells of RR-multiple sclerosis patients [PDF]
, 2016 Multiple sclerosis (MS) is characterized by pro-inflammatory cytokine production. Acetylcholine (ACh) contributes to the modulation of central and peripheral inflammation.
Biagioni, Stefano +11 more
core +2 more sources
Journal of Experimental and Molecular Biology, 2023 Osteosarcoma (OS), a malignancy primarily affecting children and adolescents, is the most frequently encountered malignant, non-hematologic, bone tumor.
Alexandru Bogdan Stache +7 more
doaj +1 more source
Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancy [PDF]
, 2017 Obesity increases preeclampsia risk. Adipose tissue inflammation may contribute to the clinical syndrome of pre-eclampsia. We compared adipose tissue macrophage infiltration and release of pro-inflammatory adipokines in pre-eclampsia and healthy ...
Bray, Jack +6 more
core +1 more source
Nature Communications, 2017 Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II) gene underlie heritable pulmonary arterial hypertension (HPAH). Although inflammation promotes PAH, the mechanisms by which inflammation and BMPR-II dysfunction
Liam A. Hurst +14 more
semanticscholar +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
p22phox C242T Single-Nucleotide Polymorphism Inhibits Inflammatory Oxidative Damage to Endothelial Cells and Vessels. [PDF]
, 2016 BACKGROUND: The NADPH oxidase, by generating reactive oxygen species, is involved in the pathophysiology of many cardiovascular diseases and represents a therapeutic target for the development of novel drugs.
Brooks, G +6 more
core +1 more source
Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging [PDF]
, 2020 Microglia express constitutively a Nox2 enzyme that is involved in neuroinflammation by the generation of reactive oxygen species (ROS). Amyloid β (Aβ) plays a crucial role in Alzheimer’s disease.
Fan, Lampson M. +4 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source