Results 61 to 70 of about 253,142 (331)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

FUNCTIONAL POLYMORPHISM OF THE PRO-INFLAMMATORY CYTOKINE GENES IN PULMONARY TUBERCULOSIS

Медицинская иммунология, 2019
In the present time, incidence of pulmonary tuberculosis (TB) becomes broader, due to spreading resistance of Mycobacterium tuberculosis (MBT) to anti-tuberculosis drugs and infection with highly virulent strains of M. tuberculosis.
E. G. Churina, O. I. Urazova, V. V. Novitsky, A. V. Sitnikova, S. E. Barmina   +4 more
doaj   +1 more source

Plasma microRNA Signature as Predictive Marker of Clinical Response to Therapy During Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite the availability of effective therapies for Multiple Sclerosis (MS), the unpredictable nature of disease progression and the variability in individual treatment outcomes call for reliable biomarkers. This pilot study aims to investigate the potential of plasma circulating microRNAs (miRNAs) as predictive biomarkers for ...
Fortunata Carbone, Alessandra Colamatteo, Teresa Micillo, Gianmarco Abbadessa, Silvia Garavelli, Clorinda Fusco, Claudia Russo, Francesco Perna, Federica Garziano, Claudia La Rocca, Maria Mottola, Giorgia Teresa Maniscalco, Simona Bonavita, Antonio Luca Spiezia, Alessia Castiello, Roberta Lanzillo, Vincenzo Brescia Morra, Claudio Procaccini, Paola de Candia, Giuseppe Matarese   +19 more
wiley   +1 more source

TAK1 safeguards endothelial cells from gut microbes and inflammation

Molecular & Cellular Oncology, 2019
How endothelial cells (ECs) survive in inflammatory environments remains unclear. We recently showed that TAK1 protects ECs against apoptosis induced by TNFα under physiological conditions in the intestine and liver, and under inflammatory conditions in ...
Hisamichi Naito, Nobuyuki Takakura
doaj   +1 more source

CHARACTERISTICS OF LOCAL INFLAMMATION IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE: DEPENDENCE ON SEVERITY STAGE

Медицинская иммунология, 2014
A group of 112 patients with chronic obstructive pulmonary disease of severity were included into the study. Differential cell counts, IL-8, TNFα, and IL-10 concentrations were assayed in sputum and bronchial lavage.
L. Yu. Dolinina, A. N. Delievа, E. O. Bogdanovа, O. V. Galkina, V. I. Trofimov   +4 more
doaj   +1 more source

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-kappa B activation [PDF]

, 2014
Pro-inflammatory cytokine-induced activation of nuclear factor, NF-κB has an important role in leukocyte adhesion to, and subsequent migration across, brain endothelial cells (BECs), which is crucial for the development of neuroinflammatory disorders ...
Baker, D, Cerutti, C, de Vries, HE, Hirst, MC, King-Robson, J, Lopez-Ramirez, MA, Male, DK, Michael, GJ, Pryce, G, Romero, IA, Sharrack, B, Simpson, JE, van der Pol, SMA, Wu, D   +13 more
core   +2 more sources

Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia [PDF]

, 2020
Background: Cachexia, a multifactorial syndrome affecting more than 50% of patients with advanced cancer and responsible for ~20% of cancer-associated deaths, is still a poorly understood process without a standard cure available. Skeletal muscle atrophy
Chiappalupi, S., Coletti, D., Donato, R., Renga, G., Riuzzi, F., Romani, L., Sagheddu, R., Salvadori, L., Sorci, G., Vukasinovic, A.   +9 more
core   +1 more source

Metabolic Consequences of Rheumatoid Arthritis

Arthritis Care &Research, EarlyView.
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry, Emily Sheng, Joshua F. Baker   +2 more
wiley   +1 more source

DYNAMICS OF CYTOKINE PROFILE IN PATIENTS WITH RHEUMATOID ARTHRITIS AS INFLUENCED BY INFLIXIMAB (REMIKEID) ADMINISTRATION

Медицинская иммунология, 2014
. Rheumatoid arthritis (RA) is a chronic autoimmune systemic disease with predominantly destructive lesions of peripheral joints, with prevalence of 0.6 to 1.6% in general population.
E. S. Zhugrova, V. I. Mazurov, A. M. Lila, K. A. Syssoev, S. V. Lapin, Areg A. Totolian   +5 more
doaj   +1 more source

Profound reduction in tamoxifen active metabolite endoxifen in a breast cancer patient treated with rifampin prior to initiation of an anti-TNFα biologic for ulcerative colitis: a case report [PDF]

BMC Cancer, 2016
Tamoxifen, a common anti-estrogen breast cancer medication, is a prodrug that undergoes bioactivation via cytochrome P450 enzymes, CYP2D6 and to a lesser degree, CYP3A4 to form the active metabolite endoxifen. With an increasing use of oral anti-cancer drugs, the risk for drug-drug interactions mediated by enzyme inhibitors and inducers may also be ...
Henderson, Sara L., Teft, Wendy A., Kim, Richard B.   +2 more
openaire   +5 more sources