Results 171 to 180 of about 3,516,666 (358)

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

TNF-α-dependent loss of monolayer resistance in HDMEC does not depend on SFK activity.

, 2016
A, Three days after cells were seeded at confluence on 8W10E ECIS electrodes, complete growth media was replaced by EBM-2 containing 0.3% FBS and incubated for another 16 hours. Then, cells were treated with different amounts of TNF-α (as shown). TEER at
Nina Martino (3108468), Hiba Alsaffar (119795), Anthony M. Lowery (358495), Peter A. Vincent (3108471), Alejandro P. Adam (55143)   +4 more
core   +1 more source

Circulating TNF-α levels in rheumatoid arthritis: a systematic review and meta-analysis and comparison to TNF-α levels in sepsis

Therapeutic Advances in Infectious Disease
Background: Tumor necrosis factor-alpha (TNF-α) is implicated in the pathogenesis of autoimmune conditions and sepsis. Although anti-TNF-α therapies have demonstrated clinical efficacy in rheumatoid arthritis (RA), there is no established evidence for ...
Sias Scherger, Andrés F. Henao-Martinez, Carlos Franco-Paredes, Binh T. Ngo, Alyssa Grimshaw, Ranjit Sah, Sangam Shah, Stefan Sillau, Alfonso G. Bastias, Michaele Francesco Corbisiero, Hannah M. Kyllo, Jordan Stellern, Leland Shapiro   +12 more
doaj   +1 more source

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

TNF-α activates autophagy in A7r5 cells through an-IKKα dependent pathway.

, 2018
(A) Western blot analysis of Beclin1, p62, LC3-II and GAPDH in A7r5 cells stimulated with 0, 1, 10 and 100 ng/mL of TNF-α (n = 4; *pB) Western blot analysis of Beclin1, p62, LC3-II and GAPDH in A7r5 cells incubated with TNF-α (100 ng/mL) at 0, 3, 16, 24 ...
Nicole Cancino-Arenas (5210993), Jaime A. Riquelme (2967201), Constanza Nuñez-Soto (5210996), Fernanda Sanhueza-Olivares (5211002), David Mondaca-Ruff (5211005), Alejandra San Martín (484118), Ignacio Norambuena-Soto (5211011), Marina García-Miguel (5210999), Pablo E. Morales (5211008), Mario Chiong (2179764)   +9 more
core   +1 more source

Pathogenetic and Therapeutic Applications of Tumor Necrosis Factor-α (TNF-α) in Major Depressive Disorder: A Systematic Review

International Journal of Molecular Sciences, 2016
Major depressive disorder (MDD) is characterized by mood, vegetative, cognitive, and even psychotic symptoms and signs that can cause substantial impairments in quality of life and functioning.
Ke-Jia Ma, Hong-Xiu Zhang, Zulqarnain Baloch   +2 more
semanticscholar   +1 more source

Effect of Vitamin D Supplementation on Irisin, Telomerase, Klotho, and Tumor Necrosis Factor-alpha (TNF-α) in Elderly: A Quasi-Experimental Study

Althea Medical Journal
Background: Vitamin D plays a crucial role in aging by regulating mitochondrial function, inflammation, oxidative stress, and telomere stability. Vitamin D deficiency is common among the elderly and is linked to accelerated aging. Biomarkers such as irisin, telomerase, klotho, and tumor necrosis factor-alpha (TNF-α) are associated with aging processes.
Diniwati Mukhtar, Nunung Ainur Rahmah, Sri Wuryanti, Himmi Marsiati, Desi Ariyani Haddad, Sabarina Elfrida Manik, Linda Weni, Bistamy Muhammad Nursabur, Andrea Ivana Allicia Hutabarat, Switania Putri Puspita   +9 more
openaire   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Alteration of dopamine, homovanillic acid (HVA) with interleukine-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in cerebral palsy

Biodiversitas Journal of Biological Diversity, 1970
Now, diagnosis of cerebral palsy base only on clinical finding without involve the alteration of the neurochemistry cause by cerebral hypoxic, although cerebral palsy is a syndrome cause by cerebral hypoxic; so, the accuracy diagnosis of this disease is very low.
openaire   +2 more sources

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source