Results 51 to 60 of about 1,312,052 (154)
Small-molecule inhibitors get pro-inflammatory TNF into shape
, 2020 Newly discovered small-molecule TNF inhibitors serve as antagonists of pro-inflammatory TNF signalling by uniquely harnessing the conformational plasticity of trimeric TNF.
Dirk Elewaut +5 more
core +1 more source
Golimumab (anti-TNF monoclonal antibody): where we stand today
Human Vaccines & Immunotherapeutics, 2021 Tumor necrosis factor (TNF) is a pro-inflammatory cytokine and its overexpression has been implicated in the pathophysiology of several chronic immune-mediated inflammatory diseases.
Ana Teresa Melo +2 more
doaj +1 more source
Biomedicines, 2021 Natural products (NPs) have played a significant role in drug discovery for diverse diseases, and numerous attempts have been made to discover promising NP inhibitors of tumor necrosis factor α (TNF-α), a major therapeutic target in autoimmune diseases ...
Lei Peng +4 more
doaj +1 more source
Development of a novel class of CBP/EP300 bromodomain inhibitors which block TNF-α induced NFκB signaling [PDF]
Tumor Necrosis Factor α (TNF-α) is an inflammatory cytokine that is a key mediator in autoimmune disorders such as Crohn’s disease and rheumatoid arthritis (RA).
Amedeo, Caflisch +9 more
core +1 more source
TNF inhibitors and extraarticular RA Personal non-commercial use only [PDF]
, 2020 . Objective. The aims of this study were to evaluate whether treatment with tumor necrosis factor (TNF) inhibitors in patients with rheumatoid arthritis (RA) affects the risk of developing severe extraarticular rheumatoid arthritis (ExRA ...
Ingemar F Jacobsson +8 more
core
Tumor necrosis factor (TNF) inhibitors
, 2016 The tumor necrosis factor (TNF) inhibitors are protein constructs which bind and inactivate TNF. They are members of a group of proteins commonly termed biological response modifiers (BRMs) or biological disease-modifying antirheumatic drugs (bDMARDs ...
Mahler, Stephen M. +2 more
core +1 more source
Effect of tumor necrosis factor-α inhibitors on ambulatory 24-h blood pressure
Blood Pressure, 2017 Tumor necrosis factor alpha (TNF-α) inhibitors are increasingly being used in inflammatory rheumatic diseases (IRD). The risk of cardiovascular disease is elevated in patients with IRD and TNF-α inhibitors reduce this risk.
Chagai Grossman +4 more
doaj +1 more source
Risk of Tuberculosis in Children with Juvenile Idiopathic Arthritis: A Nationwide Population-Based Study in Taiwan. [PDF]
PLoS ONE, 2015 We aimed to determine the risk of tuberculosis in children with juvenile idiopathic arthritis (JIA) in Taiwan.We used the Taiwan National Health Insurance Research Database (NHIRD) to conduct a nested case-control study.
Yi-Chen Hsin +5 more
doaj +1 more source
Ulusal Romatoloji DergisiObjective: With increasing use of biologics targeting multiple pathways in treatment-resistant spondyloarthritis (SpA), understanding patient characteristics has become crucial.
Gözde Duygu İşbilir +10 more
doaj +1 more source
Clinical information on AS patients who resumed TNF inhibitors.
, 2016 Clinical information on AS patients who resumed TNF inhibitors.
Yong-Gil Kim (2622202) +17 more
core +1 more source