Results 71 to 80 of about 1,312,052 (154)

TNF-alpha inhibitors for ankylosing spondylitis

, 2015
Background: TNF (tumor necrosis factor)-alpha inhibitors block a key protein in the inflammatory chain reaction responsible for joint inflammation, pain, and damage in ankylosing spondylitis.
Boonen, A (15528854), Veras, MMS (15662558), Wells, GA (15581579), Maxwell, LJ (15581558), Tugwell, P (15581582), Ghogomu, ET (15662561), Singh, JA (15565766), Jandu, MB (15662564), Zochling, J (15526052)   +8 more
core  

Demographic and clinical features in patients in patients exposed to TNF inhibitors.

, 2019
Demographic and clinical features in patients in patients exposed to TNF inhibitors.
Jeruza Lavanholi Neyeloff (5889890), Rafael Mendonça da Silva Chakr (8066453), Afonso Papke (8066450), Natália Sarzi Sartori (8066444), Paulo Picon (8066447)   +4 more
core   +1 more source

New and emerging oral therapies for psoriasis

Drugs in Context
Psoriasis is a chronic inflammatory skin disease affecting 2–3% of the global population. Traditional systemic treatments, such as methotrexate, cyclosporine, acitretin and fumaric acid esters, have limited efficacy and are associated with significant ...
Orhan Yilmaz, João Pedro Pinto, Tiago Torres   +2 more
doaj   +1 more source

Pharmacodynamics of TNF α inhibitors for the treatment of psoriasis

, 2019
Introduction: The treatment of psoriasis with conventional topical therapies and disease-modifying anti-rheumatic drugs (DMARDs) is often linked to unsatisfactory outcomes and the risk of serious adverse events.
Martina E, Offidani A., Diotallevi F, Campanati A, Paolinelli M, Molinelli E   +5 more
core   +1 more source

The Risk of Tuberculosis and TNF-alpha Inhibitors

, 2017
The clinical use of TNF-alpha inhibitors have been increasing in the treatment of autoimmune disorders. The most common anti-TNF-alpha agents on clinical use are ethanercept, infliximab and adalimumab.
Sourer, Ayper, Sutcu, Murat, Salman, Nuran, Acar, Manolya   +3 more
core   +1 more source

Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review

Indian Dermatology Online Journal
Background: Inflammatory dermatological conditions, including psoriasis, lichen planus, eczema, and alopecia areata, are frequently accompanied by nail findings and can have a significant impact on quality of life. Biologic and small-molecule medications
Carrie A. Forman, Shari R. Lipner
doaj   +1 more source

Subcutaneously-Administered Infliximab in the Management of Rheumatoid Arthritis: A Short Narrative Review of Current Clinical Evidence

Journal of Inflammation Research, 2022
Florenzo Iannone,1 Fabrizio Conti,2 Alberto Cauli,3 Alberto Farina,4 Roberto Caporali5 1Rheumatology Unit, Department of Emergency and Organ Transplantation, Università Degli Studi Di Bari Aldo Moro, Bari, Italy; 2Rheumatology Unit, Department of ...
Iannone F, Conti F, Cauli A, Farina A, Caporali R   +4 more
doaj  

In Silico Discovery of Plant-Origin Natural Product Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

Frontiers in Pharmacology, 2018
An in silico drug discovery pipeline for the virtual screening of plant-origin natural products (NPs) was developed to explore new direct inhibitors of TNF and its close relative receptor activator of nuclear factor kappa-B ligand (RANKL), both ...
Georgia Melagraki, Evangelos Ntougkos, Dimitra Papadopoulou, Dimitra Papadopoulou, Vagelis Rinotas, Vagelis Rinotas, Georgios Leonis, Eleni Douni, Eleni Douni, Antreas Afantitis, Antreas Afantitis, George Kollias, George Kollias   +12 more
doaj   +1 more source

Design and Synthesis of Cyclic Inhibitors of Matrix Metalloproteinases and TNF-α Production

, 2016
Design and Synthesis of Cyclic Inhibitors of Matrix Metalloproteinases and TNF-α ...
Xiaohua He (361530), William F. DeGrado (276486), John Roderick (3012573), Robert J. Cherney (2354959), David J. Nelson (1280958), Robert A. Copeland (672514), Chu-Biao Xue (2139553), Karl D. Hardman (2715985), Carl P. Decicco (2292961), Bruce D. Jaffee (3012585)   +9 more
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Evolving role of immunology in chronic pain medicine: tissue necrosis factor and interleukin modulatory treatments

Exploration of Immunology
Our immune system acts to protect us in times of stress and traumatic injury. As part of the immune response, the body produces various cytokines, which mediate or modulate immune functions.
Rucha A. Kelkar, Alan D. Kaye, Dominique M. Perilloux, Alison M. Hawkins, Grace C. Wester, Amanda R. Ragland, Sage V. Hebert, Sahar Shekoohi, Giustino Varrassi   +8 more
doaj   +1 more source