Results 101 to 110 of about 22,212 (273)

A shared mechanism for TNP-ATP recognition by members of the P2X receptor family

Computational and Structural Biotechnology Journal
P2X receptors (P2X1–7) are non-selective cation channels involved in many physiological activities such as synaptic transmission, immunological modulation, and cardiovascular function.
Xiao-Bo Ma, Chen-Xi Yue, Yan Liu, Yang Yang, Jin Wang, Xiao-Na Yang, Li-Dong Huang, Michael X. Zhu, Motoyuki Hattori, Chang-Zhu Li, Ye Yu, Chang-Run Guo   +11 more
doaj   +1 more source

NSD2 Coordinates the Neurogenic‐to‐Gliogenic Transition via H3K36me2‐Dependent Activation of the EGFR‐ERK Pathway

Advanced Science, Volume 13, Issue 57, 14 October 2026.
NSD2 coordinates the neurogenic‐to‐gliogenic transition in the developing neocortex through H3K36me2‐dependent activation of EGFR–ERK signaling. Loss of NSD2 disrupts astroglial and oligodendroglial development, whereas ERK activation rescues gliogenic defects in vitro and in vivo.
Hanxue Chen, Mengyuan Li, Lin Hou, Bin Yin, Boqin Qiang, Ran Gao, Pengcheng Shu, Xiaozhong Peng   +7 more
wiley   +1 more source

Sodium-Doped Carbon Dots as Fluorescent Sensor for Highly Selective Detection of TNP Explosives in the Environment

Nanomanufacturing
Given the environmental hazards of 2,4,6-trinitrophenol (TNP) and the limitations of existing detection methods, sodium-doped fluorescent carbon dots (Na-CDs) were successfully synthesized via a one-step hydrothermal method using citric acid and ascorbic
Tianyu Gao, Xuehua Sun, Hongmei Chai
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Introduction. Le TNP de Vilar : « Un mystère en pleine lumière »

, 2015
« Un mystère en pleine lumière » : ainsi Jean Vilar qualifie-t-il le Théâtre National Populaire (désormais cité : TNP) qu’il a dirigé de 1951 à 1963. Le mystère, chose cachée, secrète, au caractère incompréhensible et obscur, contraste avec la visibilité
Fleury, Laurent
core   +1 more source

Modified Titanium Dental Implants: The Current Progress of Soft‐Tissue Integration Methods

Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
Dental implants are an established solution for tooth loss, yet achieving soft tissue integration (STI) around the transmucosal region remains a challenge. The natural tooth–gingiva interface is poorly replicated on titanium implants. This review explores surface modification strategies, ranging from surface chemistry and topography to biological ...
Daniel De Maria, Amy Gelmi, Peter C. Sherrell, Stefan Di Medio, Nhiem Tran, Kate Fox   +5 more
wiley   +1 more source

The Effect of IFN-γ, Alum and Complete Freund Adjuvant on TNP-KLH Induced Ig.G1, IgE and IgG2a Responses in Mice

Mediators of Inflammation, 1994
Adjuvants are considered to play an important role in directing the isotype and amount of antibodies produced upon immunization by conducting the development of either Th-1 or Th-2 cells upon T-cell stimulation.
R. van Ommen, A. E. C. M. Vredendaal, M. de Gooyer, A. van Oudenaren, H. F. J. Savelkoul   +4 more
doaj   +1 more source

A nova doutrina nuclear americana e o TNP [PDF]

, 2017
A presente análise tem como tema a eficácia e efeitos do TNP face à modificação na política nuclear americana.A presente análise tem como tema a eficácia e efeitos do TNP face à modificação na política nuclear ...
Bertonha, João Fábio
core  

Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 (AGM-1470).

British Journal of Cancer, 1994
Recently, we reported the anti-angiogenic action along with anti-tumour activity of TNP-470 (AGM-1470). In this study, the effect of TNP-470 on the growth of human umbilical vein endothelial (HUVE) cells was examined. TNP-470 inhibited the growth of HUVE
M. Kusaka, K. Sudo, E. Matsutani, Y. Kozai, S. Marui, T. Fujita, D. Ingber, Judah Folkman   +7 more
semanticscholar   +1 more source

Titanium Dioxide Exacerbates Calcium Phosphate and Urate‐Induced Oxidative Stress, Injury and Inflammatory Response in Human Kidney‐2 Cells

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.
Graphical summary of the proposed mechanism displaying the synergistic effects of titanium dioxide nanoparticles (TNPs) exacerbating renal injury induced by CaP and UA crystals in HK2 cells. Store operated Ca2+ entry (SOCE) mediated Ca2+ influx promotes enhanced oxidative stress, activating inflammatory, fibrotic, and apoptotic pathways.
Samshritha R. Bikki, Aditi Mohapatra, Samuel Shin, Bidhan C. Bandyopadhyay   +3 more
wiley   +1 more source