Results 91 to 100 of about 84,630 (297)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Introducing oral tobacco for tobacco harm reduction: what are the main obstacles?

Harm Reduction Journal, 2007
With the number of smokers worldwide currently on the rise, the regular failure of smokers to give up their tobacco addiction, the direct role of smoke (and, to a much lesser extent, nicotine) in most tobacco-related diseases, and the availability of ...
Bohadana Abraham, Martinet Yves, Fagerström Karl   +2 more
doaj   +1 more source

TOBACCO HARM REDUCTION INVOLVES MORE THAN CIGARETTE HARM REDUCTION

American Journal of Public Health, 2004
I contributed to the Institute of Medicine report Clearing the Smoke: Assessing the Science Base for Tobacco Harm Reduction,1 and I am writing to correct misrepresentations made about it in 2 recent articles in the Journal.2,3 The articles suggest that the report signals a rebirth of “safer cigarettes”2 and that it was primarily about cigarette harm ...
openaire   +3 more sources

Natural Variation of NAR5 Determines Nitrogenase Activity and the Yield in Soybean

Advanced Science, EarlyView.
This study identified NAR5, a gene encoding a subtilisin‐like protease, that regulates nitrogenase activity in soybean nodules. Overexpressing NAR5 delayed nodule senescence, enhancing nitrogenase activity, yield, and low‐nitrogen tolerance. The elite haplotype NAR5HapI‐1 linked to superior nitrogenase activity and greater seed weight has been ...
Chao Ma, Hanyu Zhao, Haojie Feng, Xulun Dong, Lin Chen, Mingliang Yang, Runyi Chen, Chengjun Lei, Chunyan Liu, Qingshan Chen, Dawei Xin, Jinhui Wang   +11 more
wiley   +1 more source

Smokeless tobacco, ENDS and harm reduction: ¿trick or treat?

Tobacco Prevention and Cessation, 2018
Introduction The harm reduction arises to reduce diseases related to tobacco or previous step to the abstinence. Historically, faced with the concern of its customers, the tobacco industry exploited this concept to promote cigarettes with filters, light ...
Jose Manuel Iglesias-Sanmartin, Rodrigo Córdoba-García, Vidal Barchilon-Cohen   +2 more
doaj   +1 more source

Is smokeless tobacco a healthier option in patients with AUD? A follow-up study during treatment [PDF]

Introduction - Smoking is negatively related to mental health, but there is a paucity of research on the relationship between the use of smokeless tobacco, such as snus, and mental health outcomes, especially in people with alcohol use disorders (AUD ...
Bramness, Jørgen Gustav, Bolstad, Ingeborg, Lien, Lars   +2 more
core   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Tobacco: harm-reduction approaches to smoking Review 4: Barriers and facilitators to implementing tobacco harm reduction approaches; including user and provider perspectives [PDF]

, 2012
Aims of the review To review smokers’ (including their friends and family) and provider perspectives on the barriers and facilitators to implementing tobacco harm reduction (THR) approaches.
Halstead, Elizabeth, Turley, Ruth Louise, Noyes, Jane, Morgan, Helen Elizabeth, Whitehead, Sarah, Morgan, Fiona, Weightman, Alison Lesley   +6 more
core  

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source

Tobacco Harm Reduction with Vaporised Nicotine (THRiVe): The Study Protocol of an Uncontrolled Feasibility Study of Novel Nicotine Replacement Products among People Living with HIV Who Smoke

International Journal of Environmental Research and Public Health, 2017
Smoking is a leading cause of morbidity and premature mortality among people living with HIV (PLHIV), who have high rates of tobacco smoking. Vaporised nicotine products (VNPs) are growing in popularity as a quit aid and harm reduction tool.
Stephanie K Bell, J. Dean, C. Gilks, M. Boyd, L. Fitzgerald, Allyson Mutch, Peter Baker, G. Neilsen, C. Gartner   +8 more
semanticscholar   +1 more source