Results 101 to 110 of about 84,630 (297)

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

Advanced Science, EarlyView.
ABSTRACT While targeted therapies have improved outcomes in lung adenocarcinoma (LUAD), many patients still lack targetable mutations. Here, we identified alpha‐L‐fucosidase 2 (FUCA2) as a crucial driver of LUAD by preventing cellular senescence. Mechanistically, through the restriction of fucosyltransferase 3 (FUT3)‐mediated α‐1,3‐fucosylation of ...
Lu Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wenqing Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan‐yan Zhan   +18 more
wiley   +1 more source

First German-speaking harm reduction conference in Vienna

Harm Reduction Journal
The first Harm Reduction DACH Conference [DACH = D (Germany), A (Austria), CH (Switzerland)] took place in Vienna on June 23rd, 2023, and focused on tobacco harm reduction.
Larissa Steimle, Simon Fleißner, Hans Haltmayer, Thilo Beck, Alfred Springer, Heino Stöver   +5 more
doaj   +1 more source

Rediscovering cytisine: Why the WHO’s decision matters for global public health

iScience
Summary: Recently, the World Health Organization (WHO) announced the inclusion of cytisine in its Model List of Essential Medicines (EMLs). Owing to its efficacy, tolerability profile, and low cost, cytisine represents a valuable addition to the smoking ...
Riccardo Polosa, Gal Cohen
doaj   +1 more source

Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Delphi consensus methodology to gauge expert perspectives on smoking prevention, cessation and harm reduction in Italy

Frontiers in Psychiatry
The role of smoke-free alternatives to cigarettes for tobacco harm reduction remains controversial. This study was conducted to understand the perspectives of a panel of Italian experts on this topic.
Pasquale Caponnetto, Pasquale Caponnetto, Vincenzo Contursi, Francesco Fedele, Fabio Lugoboni, Salvatore Novo   +5 more
doaj   +1 more source

The Concept of Harm Reduction from Tobacco: Past, Present, Future

, 2021
The concept of tobacco harm reduction (THR) is a speculative and controversial topic in the context of the international battle against the use of all types of tobacco.
M. V. Gorbunova, A. G. Malyavin, S. L. Babak, I. V. Shashenkov   +3 more
core   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

What Do We Know About Smoking Alternatives? A Study on IQOS Tobacco Heaters

Quality in Sport
Introduction Nicotine addiction poses a significant public health concern in Poland, exacerbated by smoking, e-cigarettes, and heated tobacco products.
Filip Nadolny, Jędrzej Jabłoński, Martyna Kania, Agnieszka Adamowska, AlicJa Śniatała, Hanna Bartkowiak, Damian Grubski, Kacper Ziarnik   +7 more
doaj   +1 more source

Patient–physician communication regarding electronic cigarettes

Preventive Medicine Reports, 2015
Introduction: Smokers are likely asking their physicians about the safety of e-cigarettes and their potential role as a cessation tool; however, the research literature on this communication is scant.
Michael B. Steinberg, Daniel P. Giovenco, Cristine D. Delnevo   +2 more
doaj   +1 more source

Understanding the emergence of the tobacco industry's use of the term tobacco harm reduction in order to inform public health policy [PDF]

, 2014
Objectives: To explore the history of transnational tobacco companies’ use of the term, approach to and perceived benefits of ‘harm reduction’. Methods: Analysis of internal tobacco industry documents, contemporary tobacco industry literature and 6 ...
Peeters, Silvy, Silvy Peeters, Gilmore, Anna B., Anna B Gilmore   +3 more
core   +1 more source