Results 111 to 120 of about 6,457,654 (397)

ZSL Orchestrates Synaptonemal Complex Assembly as a Central Region Scaffold to Ensure Synapsis Fidelity and Crossover Control in Polyploid Meiosis

Advanced Science, EarlyView.
A central molecular adaptor, ZSL, is identified that links transverse filaments ZYP1 to central element SCEP1/2 to drive synaptonemal complex assembly in Brassica napus. Loss of ZSL abolishes synaptonemal complex formation, disrupts meiotic chromosome segregation, and markedly increases crossovers, providing mechanistic insight into meiotic fidelity ...
Miaowei Geng, Shaochen Jia, Fei Cao, Cuiping Liu, Heshuang Zhang, Gang Xu, Jixin Zhuang, Yashi Zhang, Can Liu, Yuhang Zhao, Zilin Guo, Xinjie Yuan, Jiaqing Yang, Lei Chu, Bowei Cai, Hu Zhao, Chao Yang   +16 more
wiley   +1 more source

Acute effects of heated tobacco product (IQOS) aerosol-inhalation on lung tissue damage and inflammatory changes in the lungs.

Nicotine & Tobacco Research, 2020
INTRODUCTION Emerging heated tobacco products (HTPs) were designed to reduce exposure to toxicants from combustible cigarettes (CS) by avoiding burning tobacco and instead heating tobacco.
T. A. Bhat, S. Kalathil, Noel J. Leigh, T. Muthumalage, I. Rahman, M. Goniewicz, Y. Thanavala   +6 more
semanticscholar   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Regulation and promotion of an addictive product : Spanish tobacco business in the spread of cigarette consumption (1880s to 1930s). [PDF]

Tobacco is an addictive product, a big business and an important source of fiscal revenues. From 1880s to 1930s tobacco consumption spread in Western World mainly in the form of cigarettes.
Gálvez Muñoz, Lina
core   +3 more sources

Attractiveness and determinants of different tobacco products among Chinese smokers and non-smokers: a web-based cross-sectional study

Frontiers in Public Health
BackgroundTobacco use remains highly prevalent in China, with the emergence of a growing range of tobacco and nicotine products that vary in design and social presentation, raising questions about how these product characteristics are perceived by ...
Ting Fei, Dawei Yan, Xiaomin Liu, Yuyan Li, Yihan Gao, Xiaonan Li, Guangchao Liu, Bingxue Wu, Yishi Jiang, Yan Zhang, Yan Che, Saijing Zheng   +11 more
doaj   +1 more source

Ensuring sustainability and dissemination of TPD and JATC activities in Europe

Tobacco Induced Diseases, 2018
The Tobacco Products Directive (TPD) is a complex binding European Union (EU) legislative document. The aim of the TPD is to preserve a high level of European public health and support the functioning of the internal market of tobacco products in the EU.
Constantine I. Vardavas, Panagiotis Behrakis, Anna Tzortzi, Biljana Kilibarda   +3 more
doaj   +1 more source

Sertoli Cell‐Derived Extracellular Vesicles Orchestrate Cadmium‐Induced Testicular Inflammation and Fibrosis

Advanced Science, EarlyView.
Environmental cadmium exposure disrupts testicular homeostasis through a novel intercellular communication axis. Stressed Sertoli cells release extracellular vesicles carrying damage‐associated molecular patterns and mitochondrial fragments, which activate macrophages via TLR4/NF‐κB signaling.
Jianfeng Ma, Mailin Gan, Shuang Liang, Siyu Chen, Ziling Hao, Yiting Yang, Jiawei Lu, Qihang Wu, Yuqian Shi, Lijun Sun, Jiaxin Li, Saihao Wang, Yan Wang, Xiaofeng Zhou, Lei Chen, Ye Zhao, Li Zhu, Linyuan Shen   +17 more
wiley   +1 more source

A health education intervention study on tobacco consumption among the urban slum residents of central India

International Journal of Preventive Medicine, 2019
Background: Tobacco is one of the world's leading avoidable causes of premature death, disease, and disability. According to the World Health Organization (WHO) survey 2020, there are about 120 million tobacco users in India, and WHO estimates that about
Anshuman Sharma, Sanjeev Kumar Gupta, Sanjay Agrawal, Sanjay Kumar Gupta, Shalini Sarouthia   +4 more
doaj   +1 more source

Adolescents’ responses to the promotion and flavouring of e-cigarettes [PDF]

, 2015
Objectives The purpose of the study is to examine adolescents’ awareness of e-cigarette marketing and investigate the impact of e-cigarette flavour descriptors on perceptions of product harm and user image.
A Amos, A Richardson, Allison Ford, Anne Marie MacKintosh, C Lovato, CM Carpenter, Crawford Moodie, CW Trumbo, E Fuller, G Kong, G Moore, Gerard Hastings, GF Wayne, JC Duke, JK Pepper, K Hughes, KE Farsalinos, KF Harrington, L Bauld, Linda Bauld, MJ Sirgy, MM Vennemann, R Kornfield, S Hosany, S Krishnan-Sarin, S Shiffman, SH Zhu, TA Wills   +27 more
core   +3 more sources

Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits

Advanced Science, EarlyView.
A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu, Mei Yuan, Li‐Juan Tang, Fenglin Wang, Xia Chu, Jian‐Hui Jiang   +5 more
wiley   +1 more source