Results 161 to 170 of about 106,112 (301)

The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui, Marnie Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Akira Sekikawa, Tullia C. Bruno, Toren Finkel, Anne B. Newman   +11 more
wiley   +1 more source

Administration Timing and Efficacy of Tocilizumab in Patients With COVID-19 and Elevated IL-6 [PDF]

, 2021
Pan Li, Zhengmao Lu, Qiang Li, Zhenmeng Wang, Yan Guo, Chen Cai, Shengyun Wang, Peng Liu, Xiaoping Su, Yi Huang, Yuchao Dong, Wenjuan Qiu, Yueming Ling, Lonny Yarmus, Fengming Luo, Li Zeng, Chong Bai, Wei Zhang   +17 more
openalex   +1 more source

Clinical features and comorbidity patterns in early and very early rheumatoid arthritis: Insights from a China nationwide survey

Rheumatology &Autoimmunity, EarlyView.
Haojie Xu, Liyun Zhang, Yuehong Huo, Rui Wu, Lijun Wu, Ling Lei, Linyu Geng, Chunyu Tan, Xiaomei Li, Ru Li, Yin Su, the Women's Rheumatoid Arthritis Research Collaborative Group   +11 more
wiley   +1 more source

Fatal Chronic Varicella‐Zoster Viral Infection in a Young Man With Chediak–Higashi Syndrome

Pediatric Dermatology, EarlyView.
ABSTRACT Chediak–Higashi syndrome (CHS) is a rare autosomal recessive primary immunodeficiency characterized by partial oculocutaneous albinism, neurologic involvement, and a predisposition to severe infections. Patients are particularly susceptible to developing hemophagocytic lymphohistiocytosis (HLH), which significantly worsens prognosis. We report
Albane Badet, Clément Pruvot, Zoé Manssens, Wadih Abou‐Chahla, Sébastien Buche   +4 more
wiley   +1 more source

High-Dose Dexamethasone Versus Tocilizumab in Moderate to Severe COVID-19 Pneumonia: A Randomized Controlled Trial [PDF]

, 2021
Naveen Naik B, Goverdhan D Puri, Kamal Kajal, Varun Mahajan, Ashish Bhalla, Sandeep Kataria, Karan Singla, Pritam Panigrahi, Ajay Pratap Singh, Michelle Lazar, Anjuman Chander, Venkata Ganesh, Amarjyoti Hazarika, Vikas Suri, Manoj Goyal, Vijayant Kumar Pandey, Narender Kaloria, Tanvir Samra, Kulbhushan Saini, Shiv Lal Soni   +19 more
openalex   +1 more source

Phase 1 results of ZUMA-1: A multicenter study of KTE-C19 anti-CD19 CAR T cell therapy in refractory aggressive lymphoma [PDF]

, 2017
Bartlett, Nancy L, et al,, Ghobadi, Armin   +2 more
core   +2 more sources

Dermatofibrosarcoma Protuberans in Children: Favorable Outcomes Using Wide Local Excision

Pediatric Dermatology, EarlyView.
ABSTRACT Background Dermatofibrosarcoma protuberans (DFSP) is a rare and locally aggressive cutaneous sarcoma. Surgical excision remains first‐line therapy, including for pediatric patients. However, given the rarity of DFSP, specific treatment recommendations for children have not been well defined. To inform pediatric‐specific management, we analyzed
Jawad Aqeel, Claire E. Holtz, Grace A. Osborne, Steven J. Kasten, Kelly L. Harms, Elisabeth A. Pedersen   +5 more
wiley   +1 more source

Tocilizumab for refractory and/or relapsing polyarteritis nodosa [PDF]

Adrien Cottu, Chloé Grolleau, Camille Gandon, T. Mahévas, C. Lepelletier, F. Cordoliani, A. Contis, Estibaliz Lazaro, Cédric Léonard, R. Sterpu, Patricia Senet, Achille Aouba, Emmanuelle Weber, C. Morice, Emma Huard, Adrien Sanchez, Nicolas Limal, Thibault Maillet, Benjamin Terrier, Maxime Battistella, Jean‐David Bouaziz, M. Jachiet   +21 more
openalex   +1 more source

HHV‐8/KSHV in Solid Organ Transplantation: Current Gaps of Knowledge and Future Directions

Transplant Infectious Disease, EarlyView.
Risk mitigation strategies, including donors/recipients screening, DNAemia monitoring in recipients at risk, CNI‐to‐mTOR inhibitors switch, antivirals, and rituximab for KICS, may mitigate the impact of HHV‐8/KSHV infection in SOT. This review provides an update on KICS, identifies research gaps, and summarizes advances in screening and management ...
Alessandra Mularoni, Andrea Cona, Malgorzata Mikulska, Francesca Pecoraro, Carlotta Piazza, Elda De Vita, Giada Pietrosi, Matteo Bulati, Tiziana Lazzarotto, Mario Luppi   +9 more
wiley   +1 more source

Ameliorating effect of tocilizumab in letrozole induced polycystic ovarian syndrome in rats via improving insulin resistance and down-regulation of VEGF/ANGPT/PDGF [PDF]

, 2020
Yasmine Ibrahim, Nisreen Toni, Khaled Thabet, AbdelRahman Hegazy, Haitham Bahaa   +4 more
openalex   +1 more source