Dual Inhibition of TNF-α and IL-6R mitigates cytokine release syndrome via protection of endothelial integrity and reduction of organ damage in mouse models. [PDF]
Won H, Park E, Roh YG, Kang M, Kim N.
europepmc +1 more source
Impact of Severe COVID‐19 on Interstitial Lung Disease in Autoimmune Systemic Diseases
In this multicentre case series of 27 patients with autoimmune systemic diseases, severe COVID‐19 pneumonia led to marked interstitial lung disease (ILD) worsening, with new‐onset or progressive ILD in all survivors and NSIP‐to‐UIP transition in six cases.
Clodoveo Ferri +95 more
wiley +1 more source
Child-Onset Takayasu's Arteritis With Arteritic Anterior Ischemic Optic Neuropathy. [PDF]
Zhao M, Li J.
europepmc +1 more source
Anemia of Inflammation in Solid Tumor Patients and Practical Education for Oncologists and Nurses
Tumor‐ and immune‐derived cytokines including IL‐6, IL‐1β, TNF‐α, TGF‐β, IL‐10, and IFN‐γ drive anemia of inflammation: IL‐6/TNF‐α upregulate hepatic hepcidin to block iron export, while other cytokines suppress erythropoiesis and shorten red cell survival.
Xiaoyan Si +5 more
wiley +1 more source
Restricted cubic spline analysis of treatment duration before tocilizumab withdrawal and relapse risk in rheumatoid arthritis. [PDF]
Jiang H, Yan Y, Zhao S, Wu R.
europepmc +1 more source
In 11 patients with relapsed small cell lung cancer treated with tarlatamab, CRS occurred in 63.6% and was limited to cycle 1 day 1 or day 8; all events were Grade 1–2 and manageable without tocilizumab or treatment discontinuation. One patient developed Grade 3 ICANS and fully recovered, while NLR showed an exploratory association with CRS.
Juwhan Choi, Seunghun Lee, Sung Yong Lee
wiley +1 more source
Clinical and laboratory manifestations and treatment of children with <i>TNFRSF1A</i> gene variants. [PDF]
Alexeeva EI +20 more
europepmc +1 more source
The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti‐aging interventions can be classified into six primary categories. This paper summarizes the most promising anti‐aging strategies within each class. ABSTRACT The global prevalence of aging and age‐related diseases
Feifei Li +4 more
wiley +1 more source
Skeletal effects of JAK1/2 inhibition versu<i>s</i> IL-6 receptor blockade in rheumatoid arthritis: a <i>post hoc</i> comparative cohort analysis based on two prospective observational studies. [PDF]
Schulz N +5 more
europepmc +1 more source
Recognition and management of early complications in CAR-T cell therapy and virus-specific T-lymphocyte therapy: a practical clinical reference. [PDF]
Ussowicz M +3 more
europepmc +1 more source

