Results 141 to 150 of about 53,280 (246)
The role of neutrophils in the pathophysiology of inflammatory bowel diseases
Periodontology 2000, EarlyView.Abstract Objectives Inflammatory bowel disease (IBD) encompasses a spectrum of chronic disorders of the gastrointestinal tract, with a potential bidirectional relationship with periodontitis. Neutrophils are key regulators of immune‐inflammatory responses and play a major role in both diseases.
Joao Paulo Steffens +8 more
wiley +1 more source
The role of Janus kinase signaling in graft-versus-host disease and graft versus leukemia [PDF]
, 2018 Choi, Jaebok +3 more
core +2 more sources
Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1514-1521, June 2026.The U.S. Food and Drug Administration (FDA) used an Active Postmarket Risk Identification and Analysis (ARIA) system to address a safety issue (serious infection) identified during clinical review of an application to market ustekinumab as a treatment for Crohn's disease (CD). FDA used an active‐comparator new‐user cohort design, data from six Sentinel
Joel L. Weissfeld +9 more
wiley +1 more source
Pharmacoepidemiology and Drug Safety, Volume 35, Issue 6, June 2026.ABSTRACT Purpose Janus kinase inhibitors (JAKi) are medicines used to treat inflammatory rheumatic musculoskeletal diseases (IRMDs) and inflammatory bowel diseases (IBDs). In Europe, JAKis received marketing authorisation in 2017 for rheumatoid arthritis.
Jarno Rutanen +3 more
wiley +1 more source
Contact Dermatitis, Volume 94, Issue 6, Page 652-661, June 2026.Patch testing and repeated use (ROAT) with Lin‐OOH revealed dose‐dependent reactions in sensitised individuals. Lin‐OOH 1.0% was the most reliable patch test concentration to confirm CA in our cohort. Skin biopsy gene expression analysis shows upregulation of IL1β, IL4, GATA3 and CCL22, confirming activation of immune pathways consistent with fragrance
Sofia Botvid +8 more
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 5, Page 966-978, May 2026.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.Abstract This study established a rat spinal cord injury (SCI) model and an in vitro hypoxic astrocyte model, confirming that hypoxia promotes the formation of the cavity of injury (COI) after SCI by activating the HIF‐1α/JAK/STAT pathway, which in turn induces astrocytic necroptosis and ultimately drives the pathological progression of SCI.
Hangchuan Bi +12 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1265-1274, May 2026.With the increasing volume of clinical evidence derived from large‐scale Asian real‐world data (RWD) and the growing interest in its use in regulatory decision‐making, it is important to conduct benchmarking exercises that evaluate whether studies using Asian RWD can generate similar conclusions as randomized controlled trials (RCTs).
Hwa Yeon Ko +15 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie +7 more
wiley +1 more source