Results 151 to 160 of about 53,280 (246)

Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy. Created in BioRender. Jain, E. (2026) https://BioRender.com/x4f9o8g. ABSTRACT Osteoarthritis (OA) is a highly prevalent, disabling, and painful disease of the joints, characterized by progressive cartilage degeneration, synovial fibrosis, and pain.
Era Jain, Paul Nana Kwame Sagoe
wiley   +1 more source

Transmural Assessment at Ulcerative Colitis Diagnosis: From Prognostication to Treatment Target

JCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Ulcerative colitis (UC) has traditionally been classified as a mucosal disease, but accumulating sonographic, histopathological, and surgical evidence increasingly challenges this paradigm. This Y‐ECCO Literature Review evaluates a prospective Copenhagen IBD cohort study by Madsen et al., the largest to date examining intestinal ultrasound ...
Luisa Bertin
wiley   +1 more source

Colon-targeted pH-responsive tofacitinib beads improve ulcerative colitis outcomes with lower systemic exposure. [PDF]

Saudi Pharm J
Ibrahim IM, Qadi O, Ahmed OAA, Kamel F, Magadmi R, Alharthi S.   +5 more
europepmc   +1 more source

Extended High‐Dose Tofacitinib Induction Improves Clinical Response in Ulcerative Colitis: A Multicenter Cohort Study

JGH Open, Volume 10, Issue 5, May 2026.
ABSTRACT Background and Aims Tofacitinib, an oral Janus Kinase (JAK) inhibitor, has demonstrated efficacy for ulcerative colitis (UC) in clinical trials, but the optimal dosing regimen remains unclear. This study aims to assess the effectiveness and safety of tofacitinib for UC in a real‐world Australian cohort focusing on outcomes of standard 8‐week ...
R. Gilmore, T. Pham, R. G. Fernandes, S. Lo, E. K. Wright, O. Rosella, P. De Cruz, B. Andrew, A. Vasudevan, K. Gazelakis, G. T. Moore, L. Thin, K. Au, S. Ghaly, C. Chen, W. Mohsen, T. Goodwin, M. P. Sparrow, M. G. Ward, M. Chew, M. Garg, E. Shelton, I. C. Lawrance, A. Thorat, C. da Fonseca Pereira, J. Begun, Y. K. An   +26 more
wiley   +1 more source

Upadacitinib Results in Endoscopic Remission in Patients With Inflammatory Bowel Disease and Prior Tofacitinib Failure. [PDF]

J Clin Gastroenterol
Lee SD, Kamp KJ, Jacobs J, Harper J, Barahimi M, Clark-Snustad KD.   +5 more
europepmc   +1 more source

Multicenter experience using tofacitinib for treatment of refractory pediatric inflammatory bowel diseases in the United States

Journal of Pediatric Gastroenterology and Nutrition, Volume 82, Issue 5, Page 1218-1225, May 2026.
Abstract Objectives Tofacitinib is a selective Janus kinase (JAK‐1) inhibitor approved for the treatment of ulcerative colitis (UC) in adults. Data is limited in the pediatric population. The aim of this study was to evaluate the efficacy of tofacitinib in pediatric inflammatory bowel disease (IBD).
Denise D. Young, Jennifer E. Murphy, Mallory Chavannes, Jennifer L. Dotson, Jeanne Tung, Erica Chang, Brad Pasternak, Erin Crawford, Nancy McGreal, Jonathan Moses, Sandra C. Kim   +10 more
wiley   +1 more source

Successful treatment of refractory primary follicular mucinosis with Tofacitinib. [PDF]

An Bras Dermatol
Li YL, Fang S.
europepmc   +1 more source

Role of COL1A1 and CD44 in Modulating JAK1/STAT3‐Mediated Autophagy for Spinal Cord Injury Recovery

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 5, May 2026.
ABSTRACT Spinal cord injury (SCI) is a severe trauma to the central nervous system that often leads to motor and sensory dysfunction in patients, severely affecting their quality of life. Autophagy plays a role in the pathological process of SCI, but the specific mechanism of autophagy in this case is unknown.
Chun‐Lei Li, Qian Zhang, Li Fang, Ling‐Yun Zhou   +3 more
wiley   +1 more source

Tofacitinib in the treatment of cardiac sarcoidosis: towards steroid-sparing disease management. [PDF]

Open Heart
Frischknecht L, Stüssi-Helbling M, Tian Y, Mallone A, Farokhnia A, Buechel R, Kolios AG, Nilsson J.   +7 more
europepmc   +1 more source

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source