Results 71 to 80 of about 62,912 (312)

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source

Pain and Inflammation as Mediators of Tofacitinib Treatment Effect on Fatigue in Patients with Ankylosing Spondylitis: A Mediation Analysis

Rheumatology and Therapy, 2023
Introduction Tofacitinib is an oral Janus kinase inhibitor for treatment of ankylosing spondylitis (AS). Using mediation modelling, we describe interrelationships between fatigue, pain, morning stiffness, C-reactive protein (CRP) and tofacitinib ...
Lars Erik Kristensen, Victoria Navarro-Compán, Marina Magrey, Andrew G. Bushmakin, Joseph C. Cappelleri, Arne Yndestad, Oluwaseyi Dina, Peter C. Taylor   +7 more
doaj   +1 more source

Nuclear matrix protein 2 antibody-positive adult dermatomyositis: a case report and review of the literature [PDF]

, 2020
Dermatomyositis is a clinically heterogenous inflammatory myopathy with unique cutaneous features. Myositis-specific antibodies can aid in diagnosis and anticipation of patient prognosis.
Cartron, Alexander M, Chung, Catherine, Osler, Montana, Trinidad, John C   +3 more
core  

Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis. [PDF]

, 2017
Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cells. This study aimed to determine the osteoclastogenic role of H4R in rheumatoid arthritis (RA).
Firestein, Gary S, Kim, Bo-Mi, Kim, Hae-Rim, Kim, Kyoung-Woon, Lee, Kyung-Ann, Lee, Sang-Heon   +5 more
core   +1 more source

Risk of Venous Thromboembolism With Tofacitinib Versus Tumor Necrosis Factor Inhibitors in Cardiovascular Risk‐Enriched Rheumatoid Arthritis Patients

Arthritis & Rheumatology
The ORAL Surveillance trial found a dose‐dependent increase in venous thromboembolism (VTE) and pulmonary embolism (PE) events with tofacitinib versus tumor necrosis factor inhibitors (TNFi).
C. Charles-Schoeman, Roy M Fleischmann, E. Mysler, Maria Greenwald, S. Ytterberg, Gary G Koch, Deepak L. Bhatt, Cunshan Wang, T. Mikuls, All-shine Chen, C. Connell, J. Woolcott, S. Menon, Yan Chen, Kristen Lee, Zoltán Szekanecz   +15 more
semanticscholar   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Efficacy and safety at 24 weeks of daily clinical use of tofacitinib in patients with rheumatoid arthritis. [PDF]

PLoS ONE, 2017
We evaluated the efficacy and safety of tofacitinib in patients with rheumatoid arthritis (RA) in a real-world setting.Seventy consecutive patients, for whom tofacitinib was initiated between November 2013 and May 2016, were enrolled.
Naoki Iwamoto, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Shoichi Fukui, Masataka Umeda, Ayako Nishino, Yoshiro Horai, Tomohiro Koga, Shin-Ya Kawashiri, Toshiyuki Aramaki, Kunihiro Ichinose, Yasuko Hirai, Mami Tamai, Hideki Nakamura, Kaoru Terada, Tomoki Origuchi, Katsumi Eguchi, Yukitaka Ueki, Atsushi Kawakami   +19 more
doaj   +1 more source

Synthesis and evaluation of hydrogen peroxide sensitive tofacitinib prodrugs

European Journal of Medicinal Chemistry Reports, 2022
Tofacitinib (CP-690,550), an approved Janus kinase (JAK) inhibitor, has been proven highly efficacious in treating rheumatoid arthritis (RA). Unfortunately, tofacitinib's clinical application has been limited by adverse side effects that arise from its ...
Viola Previtali, Ulrik Bering Keiding, Asger Hegelund Olsen, Jorge Peiró Cadahía, Anne Skovsbo Clausen, Andreas Kjaer, Thomas Lars Andresen, Anders Elias Hansen, Mads Hartvig Clausen   +8 more
doaj   +1 more source

Risk of Herpes Zoster in Individuals on Biologics, DMARDS and/or Corticosteroids for Autoimmune Diseases:A Systematic Review and Meta-Analysis [PDF]

, 2016
Background: Studies examining the risk of herpes zoster (HZ) associated with immunosuppressants, such as biologics, non-biological disease modifying agents (nbDMARDs) or corticosteroids, have generated conflicting results.
Alarcón-Segovia, Bachelez, Bejarano, Bongartz, Braun, Brenner, Bresnihan, Cardiel, Che, Chen, Choy, Cohen, Cutolo, Dechartres, Dixon, Dixon, Dreiher, Egger, Emery, Emery, Fleischmann, Fleischmann, Furie, Furst, Galloway, Genovese, Genovese, Gupta, Gupta, Harpaz, Hayward, Higgins, Higgins, Hoes, Kameda, Kawai, Keystone, Kost, Kourbeti, Kremer, Kremer, Kremer, Kremer, Lal, Leonardi, Long, McDonald, Merrill, Moher, Moreland, Moutsopoulos, Nakajima, Nishimoto, Osterman, Oxman, Oxman, Papp, Pappas, Peto, Rutgeerts, Sampathkumar, Sandborn, Sandborn, Schiff, Schreiber, Segan, Shah, Singh, Smitten, Smolen, Smolen, Spittal, Strangfeld, Stroup, Sweeting, Takeuchi, Tanaka, Tanaka, van der Heijde, van Vollenhoven, Veetil, Weiner, Wells, Winthrop, Winthrop, Winthrop, Wolfe, Yamamoto, Yawn, Yawn, Youssef, Yun, Zhang, Zisman, Zorzela   +94 more
core   +1 more source

Janus kinase inhibitor, tofacitinib, in refractory juvenile dermatomyositis: a retrospective multi-central study in China

Arthritis Research & Therapy, 2023
Objectives Juvenile dermatomyositis (JDM) is a chronic autoimmune disease. Some patients remain in an active state even though they were administrated with a combination of corticosteroid and methotrexate.
Junmei Zhang, Li Sun, Xinwei Shi, Shipeng Li, Cuihua Liu, Xiaoqing Li, Mei-yuan Lu, Jianghong Deng, X. Tan, Wan-zhen Guan, Guoming Li, Xinran Wen, Ping Liu, Caifeng Li   +13 more
semanticscholar   +1 more source