Results 31 to 40 of about 4,840 (196)

The sodium-glucose co-transporter 2 inhibitor tofogliflozin suppresses atherosclerosis through glucose lowering in ApoE-deficient mice with streptozotocin-induced diabetes. [PDF]

Pharmacol Res Perspect, 2022
Tofogliflozin, a highly specific SGLT2 inhibitor, suppresses atherosclerosis by improving glucose intolerance associated with inhibition of inflammation in the diabetic ApoEKO mice. Abstract Epidemiological and animal studies have revealed that sodium‐glucose cotransporter 2 (SGLT2) inhibitors suppress cardiovascular events in subjects with type 2 ...
Iwamoto M, Kubota T, Sakurai Y, Wada N, Shioda S, Yamauchi T, Kadowaki T, Kubota N.   +7 more
europepmc   +2 more sources

Evidence of Závora Bay as a critical site for reef manta rays, Mobula alfredi, in southern Mozambique. [PDF]

J Fish Biol, 2022
Abstract The largest known reef manta ray (Mobula alfredi) population in Africa has been monitored for more than 20 years at several locations on the coast of the Inhambane Province in southern Mozambique. Nonetheless, before this study, little had been reported on the population dynamics of M.
Carpenter M, Cullain N, Venables SK, Tibiriçá Y, Griffiths C, Marshall AD.   +5 more
europepmc   +2 more sources

Deformidades por tofos gigantes

Medicina Clínica Práctica, 2019
Jose Ramón Lamúa Riazuelo
openaire   +2 more sources

De La Higuera a El Tofo. Derrotero de dos centros mineros en la penumbra de la historia (notas y reflexiones)

, 2020
El presente artículo intenta recuperar información dispersa acerca de la minería del Norte Chico, la que fue muy importante durante los siglos XIX y XX. Actualmente el pueblo de La Higuera busca en el turismo una nueva fuente de ingreso, mientras que el mineral de hierro El Tofo, que durante el siglo XX constituyó el principal yacimiento de ese metal ...
Gonzalo Ampuero
openaire   +2 more sources

Predictors of haemoglobin levels and of changes in these levels, focusing on anaemia and polycythaemia after administration of the sodium-glucose cotransporter-2 inhibitor tofogliflozin. [PDF]

Diabetes Obes Metab, 2022
Diabetes, Obesity and Metabolism, Volume 24, Issue 12, Page 2469-2473, December 2022.
Matsubayashi Y, Yoshida A, Suganami H, Oe M, Sato T, Yaguchi Y, Fujihara K, Yamada T, Tanaka S, Kaku K, Sone H.   +10 more
europepmc   +2 more sources

Basal insulin secretion capacity predicts the initial response and maximum levels of beta-hydroxybutyrate during therapy with the sodium-glucose co-transporter-2 inhibitor tofogliflozin, in relation to weight loss. [PDF]

Diabetes Obes Metab, 2020
Abstract Aims To investigate predictors of the initial response of beta‐hydroxybutyrate (BHB) and maximum BHB (max‐BHB) values during long‐term therapy with the sodium‐glucose co‐transporter‐2 inhibitor tofogliflozin (TOFO), and to explore the association of the initial elevation of BHB with subsequent clinical effects in people with type 2 diabetes ...
Sato Y, Nunoi K, Kaku K, Yoshida A, Suganami H.   +4 more
europepmc   +2 more sources

Association of increased hepatic insulin clearance and change in serum triglycerides or β-hydroxybutyrate concentration via the sodium/glucose-cotransporter 2 inhibitor tofogliflozin. [PDF]

Diabetes Obes Metab, 2020
Abstract Aims Obesity and hepatic fat accumulation diminish hepatic insulin clearance, which can cause hyperinsulinaemia. Sodium/glucose‐cotransporter 2 inhibitors (SGLT2‐is) improve insulin resistance and hyperinsulinaemia by weight loss via increased urinary glucose excretion in type 2 diabetes.
Matsubayashi Y, Yoshida A, Suganami H, Osawa T, Furukawa K, Suzuki H, Fujihara K, Tanaka S, Kaku K, Sone H, Sone H.   +10 more
europepmc   +2 more sources

Reductions in liver enzymes are associated with anti-hyperglycaemic and anti-obesity effects of tofogliflozin in people with type 2 diabetes: Post-hoc analyses. [PDF]

Endocrinol Diabetes Metab
Reductions in GGT and ALT were associated with the anti‐hyperglycaemic and anti‐obesity effects of tofogliflozin, respectively, in people with T2D. Therefore, GGT and ALT may be surrogate markers for hyperglycaemia and obesity in T2D. Abstract Aims How the pathology of type 2 diabetes (T2D), including hyperglycaemia and obesity, affects liver enzymes ...
Takamura T, Kaku K, Yoshida A, Kusakabe H, Nakamura H, Suganami H.   +5 more
europepmc   +2 more sources

Inhibition of sodium-glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease. [PDF]

FEBS Open Bio, 2019
Here, we demonstrate that the highly specific sodium‐glucose cotransporter 2 inhibitor (SGLT2I) prevented the progression of nonalcoholic steatohepatitis (NASH)‐related renal injury in a medaka fish model of NASH‐related kidney disease. SGLT2I ameliorates oxidative stress and macrophage accumulation and maintained mitochondrial function in renal ...
Nagoya T, Kamimura K, Goto R, Shinagawa-Kobayashi Y, Niwa Y, Kimura A, Sakai N, Ko M, Nishina H, Terai S.   +9 more
europepmc   +2 more sources

Merging two eDNA metabarcoding approaches and citizen‐science‐based sampling to facilitate fish community monitoring along vast Sub‐Saharan coastlines

Molecular Ecology Resources, Volume 23, Issue 7, Page 1641-1655, October 2023., 2023
Abstract The coastline of Sub‐Saharan Africa hosts highly diverse fish communities of great conservation value, which are also key resources for local livelihoods. However, many costal ecosystems are threatened by overexploitation and their conservation state is frequently unknown due to their vast spatial extent and limited monitoring budgets.
Alfred Burian, Kat Bruce, Erica Tovela, Judith Bakker, Laura Balcells, Rhett Bennett, Sarah Chordekar, Hugo M. Costa, Alex Crampton‐Platt, Hugo de Boer, Vere Ross‐Gillespie, Antonio de Sacramento, Naseeba Sidat, Luisa Simbine, Jonathan Ready, Cuong Tang, Quentin Mauvisseau   +16 more
wiley   +1 more source