Results 21 to 30 of about 238 (108)

Reductions in liver enzymes are associated with anti-hyperglycaemic and anti-obesity effects of tofogliflozin in people with type 2 diabetes: Post-hoc analyses. [PDF]

Endocrinol Diabetes Metab
Reductions in GGT and ALT were associated with the anti‐hyperglycaemic and anti‐obesity effects of tofogliflozin, respectively, in people with T2D. Therefore, GGT and ALT may be surrogate markers for hyperglycaemia and obesity in T2D. Abstract Aims How the pathology of type 2 diabetes (T2D), including hyperglycaemia and obesity, affects liver enzymes ...
Takamura T, Kaku K, Yoshida A, Kusakabe H, Nakamura H, Suganami H.   +5 more
europepmc   +2 more sources

Inhibition of sodium-glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis-related kidney disease. [PDF]

FEBS Open Bio, 2019
Here, we demonstrate that the highly specific sodium‐glucose cotransporter 2 inhibitor (SGLT2I) prevented the progression of nonalcoholic steatohepatitis (NASH)‐related renal injury in a medaka fish model of NASH‐related kidney disease. SGLT2I ameliorates oxidative stress and macrophage accumulation and maintained mitochondrial function in renal ...
Nagoya T, Kamimura K, Goto R, Shinagawa-Kobayashi Y, Niwa Y, Kimura A, Sakai N, Ko M, Nishina H, Terai S.   +9 more
europepmc   +2 more sources

Merging two eDNA metabarcoding approaches and citizen‐science‐based sampling to facilitate fish community monitoring along vast Sub‐Saharan coastlines

Molecular Ecology Resources, Volume 23, Issue 7, Page 1641-1655, October 2023., 2023
Abstract The coastline of Sub‐Saharan Africa hosts highly diverse fish communities of great conservation value, which are also key resources for local livelihoods. However, many costal ecosystems are threatened by overexploitation and their conservation state is frequently unknown due to their vast spatial extent and limited monitoring budgets.
Alfred Burian, Kat Bruce, Erica Tovela, Judith Bakker, Laura Balcells, Rhett Bennett, Sarah Chordekar, Hugo M. Costa, Alex Crampton‐Platt, Hugo de Boer, Vere Ross‐Gillespie, Antonio de Sacramento, Naseeba Sidat, Luisa Simbine, Jonathan Ready, Cuong Tang, Quentin Mauvisseau   +16 more
wiley   +1 more source

Laser photogrammetry improves size and demographic estimates for whale sharks [PDF]

PeerJ, 2015
Whale sharks Rhincodon typus are globally threatened, but a lack of biological and demographic information hampers an accurate assessment of their vulnerability to further decline or capacity to recover.
Christoph A. Rohner, Anthony J. Richardson, Clare E.M. Prebble, Andrea D. Marshall, Michael B. Bennett, Scarla J. Weeks, Geremy Cliff, Sabine P. Wintner, Simon J. Pierce   +8 more
doaj   +2 more sources

Renal effects of a sodium-glucose cotransporter 2 inhibitor, tofogliflozin, in relation to sodium intake and glycaemic status. [PDF]

Diabetes Obes Metab, 2019
Abstract Aims Little is known about whether sodium intake is associated with the clinical effects of SGLT2 inhibitors (SGLT2is); however, SGLT2is may increase urinary sodium excretion. Thus, we investigated the impact of daily sodium intake on the estimated glomerular filtration rate (eGFR) via an SGLT2i, tofogliflozin (TOFO), in patients with type 2 ...
Nunoi K, Sato Y, Kaku K, Yoshida A, Suganami H.   +4 more
europepmc   +2 more sources

Therapeutic anticoagulation to prevent thrombosis, coagulopathy, and mortality in severe COVID‐19: The Swiss COVID‐HEP randomized clinical trial

Research and Practice in Thrombosis and Haemostasis, Volume 6, Issue 4, May 2022., 2022
Abstract Background Hospitalized patients with COVID‐19 suffered initially from high rates of venous thromboembolism (VTE), with possible associations between therapeutic anticoagulation and better clinical outcomes in observational studies. Objective To test whether therapeutic anticoagulation improves clinical outcomes in severe COVID‐19.
Marc Blondon, Sara Cereghetti, Jérôme Pugin, Christophe Marti, Pauline Darbellay Farhoumand, Jean‐Luc Reny, Alexandra Calmy, Christophe Combescure, Lucia Mazzolai, Olivier Pantet, Zied Ltaief, Marie Méan, Sara Manzocchi Besson, Séverin Jeanneret, Hans Stricker, Helia Robert‐Ebadi, Pierre Fontana, Marc Righini, Alessandro Casini   +18 more
wiley   +1 more source

Tofo gotoso

Revista de la Asociación Colombiana de Dermatología y Cirugía Dermatológica, 2020
Presentamos este caso para resaltar la importancia de la identificación de los tofos gotosos en localizaciones menos clásicas, incluso en pacientes sin crisis de artritis previas, uso de terapia hipouricemiante o factores de riesgo, ya que los tofos ...
Natalia Vélez López, María Fernanda Tibaduiza, Juan David Ruiz Restrepo, Oscar Jairo Valencia Ocampo   +3 more
doaj   +1 more source

Association of estimated plasma volume and weight loss after long‐term administration and subsequent discontinuation of the sodium‐glucose cotransporter‐2 inhibitor tofogliflozin

Diabetes, Obesity and Metabolism, Volume 23, Issue 7, Page 1660-1665, July 2021., 2021
Abstract Sodium‐glucose cotransporter‐2 inhibitors (SGLT2) are drugs that have been reported to have several effects through the regulation of plasma volume, for example, antihypertensive effects. This study aimed to clarify the impact of long‐term administration and subsequent discontinuation of the SGLT2 inhibitor tofogliflozin on estimated plasma ...
Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Momoko Oe, Takaaki Sato, Yuta Yaguchi, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Kohei Kaku, Hirohito Sone   +10 more
wiley   +1 more source

Fog‐to‐Water for Water Scarcity in Climate‐Change Hazards Hotspots: Pilot Study in Southeast Asia

Global Challenges, Volume 5, Issue 5, May 2021., 2021
Water scarcity is the main growing concern in the world. During prolonged drought seasons, fog‐to‐water is one close‐at‐hand freshwater resource. A pilot study on fog‐to‐water solutions in climate‐change hazard hotspots in Southeast Asia is provided.
Zaitizila Ismail, Yun Ii Go
wiley   +1 more source

Dynamic savanna burning emission factors based on satellite data using a machine learning approach [PDF]

Earth System Dynamics, 2023
Landscape fires, predominantly found in the frequently burning global savannas, are a substantial source of greenhouse gases and aerosols. The impact of these fires on atmospheric composition is partially determined by the chemical breakup of the ...
R. Vernooij, T. Eames, J. Russell-Smith, J. Russell-Smith, C. Yates, C. Yates, R. Beatty, R. Beatty, J. Evans, J. Evans, A. Edwards, A. Edwards, N. Ribeiro, M. Wooster, M. Wooster, T. Strydom, M. V. Giongo, M. A. Borges, M. Menezes Costa, A. C. S. Barradas, D. van Wees, G. R. Van der Werf   +21 more
doaj   +1 more source