Tofogliflozin attenuates liver steatosis and fibrosis in non-diabetic non-alcoholic steatohepatitis mice [PDF]
BMC GastroenterologyBackground Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease with increasing global prevalence. Although diabetes is a major factor in NAFLD progression, up to 75% of the patients with NAFLD do not have diabetes ...
Hisayoshi Iwakiri +2 more
exaly +6 more sources
Tofogliflozin ameliorates cardiotoxin induced skeletal muscle injury and fibrosis in obesity [PDF]
Scientific ReportsObesity impairs muscle function through effects on lipid metabolism, systemic inflammation, and insulin resistance, leading to muscle loss and reduced regeneration.
Kazuyuki Tobe, Ayumi Nishimura
exaly +4 more sources
Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis [PDF]
Cells, 2022 Ballooning degeneration of hepatocytes is a major distinguishing histological feature of non-alcoholic steatosis (NASH) progression that can lead to cirrhosis and hepatocellular carcinoma (HCC).
Yusuke Sasaki +2 more
exaly +5 more sources
Effects of Progranulin Deficiency on Inflammation and Fibrosis in the Kidneys and Liver of Diabetic Mice Fed a High-Fat Diet [PDF]
Endocrinology and MetabolismBackground Progranulin (PGRN) is an important regulator of inflammation, insulin resistance, and autophagy. However, the effects of PGRN deficiency on these processes in the kidneys and liver in diabetes remain unclear.
Hiroko Sakuma +5 more
doaj +3 more sources
Effects of Tofogliflozin and Anagliptin Alone or in Combination on Glucose Metabolism and Atherosclerosis-Related Markers in Patients with Type 2 Diabetes Mellitus [PDF]
Clinical Pharmacology: Advances and Applications, 2023 Shosaku Nomura,1 Akira Shouzu,2 Takehito Taniura,3 Yoshinori Okuda,4 Seitaro Omoto,5 Masahiko Suzuki,6 Tomoki Ito,7 Nagaoki Toyoda8 1Center of Thrombosis and Hemostasis, Kansai Medical University Medical Center, Moriguchi, Japan; 2Division of Diabetes ...
Nomura S +7 more
doaj +2 more sources
The sodium-glucose co-transporter 2 inhibitor tofogliflozin suppresses atherosclerosis through glucose lowering in ApoE-deficient mice with streptozotocin-induced diabetes. [PDF]
Pharmacol Res Perspect, 2022 Tofogliflozin, a highly specific SGLT2 inhibitor, suppresses atherosclerosis by improving glucose intolerance associated with inhibition of inflammation in the diabetic ApoEKO mice. Abstract Epidemiological and animal studies have revealed that sodium‐glucose cotransporter 2 (SGLT2) inhibitors suppress cardiovascular events in subjects with type 2 ...
Iwamoto M +7 more
europepmc +2 more sources
Evidence of Závora Bay as a critical site for reef manta rays, Mobula alfredi, in southern Mozambique. [PDF]
J Fish Biol, 2022 Abstract The largest known reef manta ray (Mobula alfredi) population in Africa has been monitored for more than 20 years at several locations on the coast of the Inhambane Province in southern Mozambique. Nonetheless, before this study, little had been reported on the population dynamics of M.
Carpenter M +5 more
europepmc +2 more sources
A Mozambican marine protected area provides important habitat for vulnerable pelagic sharks [PDF]
Scientific Reports, 2023 Pelagic sharks play key roles in marine ecosystems, but are increasingly threatened by human extraction, habitat degradation and mismanagement. We investigated the use of protected and unprotected coastal habitats by bull (Carcharhinus leucas) and ...
Calum J. G. Murie +8 more
doaj +2 more sources
Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice [PDF]
Endocrine JournalWe previously demonstrated hepatic, cardiac, and skin inflammation in a high-fat diet-induced steatotic liver disease (SLD) model. However, the molecular mechanism in the kidneys in this model remains unclear.
Sae Nishihara +14 more
doaj +2 more sources
Domoic Acid and Pseudo-nitzschia spp. Connected to Coastal Upwelling along Coastal Inhambane Province, Mozambique: A New Area of Concern [PDF]
Toxins, 2021 Harmful algal blooms (HABs) are increasing globally in frequency, persistence, and geographic extent, posing a threat to ecosystem and human health.
Holly Kelchner +5 more
doaj +2 more sources