Tofogliflozin ameliorates cardiotoxin induced skeletal muscle injury and fibrosis in obesity [PDF]
Scientific ReportsObesity impairs muscle function through effects on lipid metabolism, systemic inflammation, and insulin resistance, leading to muscle loss and reduced regeneration.
Nawaz Allah +2 more
exaly +3 more sources
Revista De La Facultad De Ciencias Medicas De Cordoba, 2012 Antecedentes: La gota es una enfermedad metabólica por depósito de cristales de ácido úrico, que compromete articulaciones y tejidos blandos tanto en sus etapas agudas como crónicas.
Susana Szlabi +3 more
exaly +4 more sources
Tofo gotoso de pie como simulador de neuroma de Morton. [Feet gouty tophus as a Morton’s].
Revista de la Asociación Argentina de Ortopedia y Traumatología, 2016 Presentamos este caso para resaltar la importancia de la identificación de los tofos gotosos en localizaciones menos clásicas, incluso en pacientes sin crisis de artritis previas, uso de terapia hipouricemiante o factores de riesgo, ya que los tofos gotosos auriculares pueden ser la primera manifestación de la gota, a pesar de que se ha considerado que
Maximiliano Seletti +5 more
doaj +9 more sources
Effects of Tofogliflozin and Anagliptin Alone or in Combination on Glucose Metabolism and Atherosclerosis-Related Markers in Patients with Type 2 Diabetes Mellitus [PDF]
Clinical Pharmacology: Advances and Applications, 2023 Shosaku Nomura,1 Akira Shouzu,2 Takehito Taniura,3 Yoshinori Okuda,4 Seitaro Omoto,5 Masahiko Suzuki,6 Tomoki Ito,7 Nagaoki Toyoda8 1Center of Thrombosis and Hemostasis, Kansai Medical University Medical Center, Moriguchi, Japan; 2Division of Diabetes ...
Nomura S +7 more
doaj +2 more sources
Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis [PDF]
Cells, 2022 Ballooning degeneration of hepatocytes is a major distinguishing histological feature of non-alcoholic steatosis (NASH) progression that can lead to cirrhosis and hepatocellular carcinoma (HCC).
Kentaro Murakami +14 more
doaj +2 more sources
The sodium‐glucose co‐transporter 2 inhibitor tofogliflozin suppresses atherosclerosis through glucose lowering in ApoE‐deficient mice with streptozotocin‐induced diabetes [PDF]
Pharmacology Research &Perspectives, Volume 10, Issue 4, August 2022., 2022 Tofogliflozin, a highly specific SGLT2 inhibitor, suppresses atherosclerosis by improving glucose intolerance associated with inhibition of inflammation in the diabetic ApoEKO mice. Abstract Epidemiological and animal studies have revealed that sodium‐glucose cotransporter 2 (SGLT2) inhibitors suppress cardiovascular events in subjects with type 2 ...
Masahiko Iwamoto +7 more
wiley +2 more sources
Evidence of Závora Bay as a critical site for reef manta rays, Mobula alfredi, in southern Mozambique [PDF]
Journal of Fish Biology, Volume 101, Issue 3, Page 628-639, September 2022., 2022 Abstract The largest known reef manta ray (Mobula alfredi) population in Africa has been monitored for more than 20 years at several locations on the coast of the Inhambane Province in southern Mozambique. Nonetheless, before this study, little had been reported on the population dynamics of M.
Michelle Carpenter +5 more
wiley +2 more sources
Tofogliflozin attenuates liver steatosis and fibrosis in non-diabetic non-alcoholic steatohepatitis mice [PDF]
BMC GastroenterologyBackground Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease with increasing global prevalence. Although diabetes is a major factor in NAFLD progression, up to 75% of the patients with NAFLD do not have diabetes ...
Yoshinori Ozono +11 more
doaj +2 more sources
Effects of Progranulin Deficiency on Inflammation and Fibrosis in the Kidneys and Liver of Diabetic Mice Fed a High-Fat Diet [PDF]
Endocrinology and MetabolismBackground Progranulin (PGRN) is an important regulator of inflammation, insulin resistance, and autophagy. However, the effects of PGRN deficiency on these processes in the kidneys and liver in diabetes remain unclear.
Hiroko Sakuma +5 more
doaj +2 more sources
A Mozambican marine protected area provides important habitat for vulnerable pelagic sharks [PDF]
Scientific Reports, 2023 Pelagic sharks play key roles in marine ecosystems, but are increasingly threatened by human extraction, habitat degradation and mismanagement. We investigated the use of protected and unprotected coastal habitats by bull (Carcharhinus leucas) and ...
Calum J. G. Murie +8 more
doaj +2 more sources