Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice [PDF]
Endocrine JournalWe previously demonstrated hepatic, cardiac, and skin inflammation in a high-fat diet-induced steatotic liver disease (SLD) model. However, the molecular mechanism in the kidneys in this model remains unclear.
Sae Nishihara +14 more
doaj +2 more sources
Domoic Acid and Pseudo-nitzschia spp. Connected to Coastal Upwelling along Coastal Inhambane Province, Mozambique: A New Area of Concern [PDF]
Toxins, 2021 Harmful algal blooms (HABs) are increasing globally in frequency, persistence, and geographic extent, posing a threat to ecosystem and human health.
Holly Kelchner +5 more
doaj +2 more sources
Spotting the “small eyes”: using photo-ID methodology to study a wild population of smalleye stingrays (Megatrygon microps) in southern Mozambique [PDF]
PeerJ, 2019 Background The smalleye stingray (Megatrygon microps) is a large and rare dasyatid ray, patchily distributed across the Indo-West Pacific. Free-swimming individuals have regularly been recorded in Southern Mozambican coastal waters utilizing different ...
Atlantine Boggio-Pasqua +2 more
doaj +3 more sources
Predictors of haemoglobin levels and of changes in these levels, focusing on anaemia and polycythaemia after administration of the sodium‐glucose cotransporter‐2 inhibitor tofogliflozin [PDF]
Diabetes Obes Metab, 2022 Diabetes, Obesity and Metabolism, Volume 24, Issue 12, Page 2469-2473, December 2022.
Yasuhiro Matsubayashi +10 more
wiley +2 more sources
Basal insulin secretion capacity predicts the initial response and maximum levels of beta‐hydroxybutyrate during therapy with the sodium‐glucose co‐transporter‐2 inhibitor tofogliflozin, in relation to weight loss [PDF]
Diabetes, Obesity and Metabolism, Volume 22, Issue 2, Page 222-230, February 2020., 2020 Abstract Aims To investigate predictors of the initial response of beta‐hydroxybutyrate (BHB) and maximum BHB (max‐BHB) values during long‐term therapy with the sodium‐glucose co‐transporter‐2 inhibitor tofogliflozin (TOFO), and to explore the association of the initial elevation of BHB with subsequent clinical effects in people with type 2 diabetes ...
Yuichi Sato +4 more
wiley +2 more sources
Association of increased hepatic insulin clearance and change in serum triglycerides or β‐hydroxybutyrate concentration via the sodium/glucose‐cotransporter 2 inhibitor tofogliflozin [PDF]
Diabetes, Obesity and Metabolism, Volume 22, Issue 6, Page 947-956, June 2020., 2020 Abstract Aims Obesity and hepatic fat accumulation diminish hepatic insulin clearance, which can cause hyperinsulinaemia. Sodium/glucose‐cotransporter 2 inhibitors (SGLT2‐is) improve insulin resistance and hyperinsulinaemia by weight loss via increased urinary glucose excretion in type 2 diabetes.
Yasuhiro Matsubayashi +9 more
wiley +2 more sources
Inhibition of sodium glucose cotransporter 2 (SGLT2) delays liver fibrosis in a medaka model of nonalcoholic steatohepatitis (NASH) [PDF]
FEBS Open Bio, 2019 The rise in the incidence of nonalcoholic steatohepatitis (NASH) has necessitated the development of an effective prevention methodology. An antidiabetic drug, belonging to the group of sodium glucose cotransporter 2 (SGLT2) inhibitors, has been tested ...
Ryo Goto +14 more
doaj +2 more sources
Reductions in liver enzymes are associated with anti‐hyperglycaemic and anti‐obesity effects of tofogliflozin in people with type 2 diabetes: Post‐hoc analyses [PDF]
Endocrinology, Diabetes &Metabolism, Volume 7, Issue 1, January 2024.Reductions in GGT and ALT were associated with the anti‐hyperglycaemic and anti‐obesity effects of tofogliflozin, respectively, in people with T2D. Therefore, GGT and ALT may be surrogate markers for hyperglycaemia and obesity in T2D. Abstract Aims How the pathology of type 2 diabetes (T2D), including hyperglycaemia and obesity, affects liver enzymes ...
Toshinari Takamura +5 more
wiley +2 more sources
Inhibition of sodium‐glucose cotransporter 2 ameliorates renal injury in a novel medaka model of nonalcoholic steatohepatitis‐related kidney disease [PDF]
FEBS Open Bio, Volume 9, Issue 12, Page 2016-2024, December 2019., 2019 Here, we demonstrate that the highly specific sodium‐glucose cotransporter 2 inhibitor (SGLT2I) prevented the progression of nonalcoholic steatohepatitis (NASH)‐related renal injury in a medaka fish model of NASH‐related kidney disease. SGLT2I ameliorates oxidative stress and macrophage accumulation and maintained mitochondrial function in renal ...
Takuro Nagoya +9 more
wiley +2 more sources
Revista da ANPEGEPraia do Tofo na cidade de Inhambane constitui uma das riquezas turísticas de Moçambique e possui um elevado investimento estrangeiro que altera a produção social do espaço.
Alberto José Mate +1 more
doaj +2 more sources