Results 81 to 90 of about 10,826 (204)

Pathogenicity and virulence of O’nyong-nyong virus: A less studied Togaviridae with pandemic potential

Virulence
O’nyong-nyong virus (ONNV) is a neglected mosquito-borne alphavirus belonging to the Togaviridae family. ONNV is known to be responsible for sporadic outbreaks of acute febrile disease and polyarthralgia in Africa.
Samuel Tong Jia Ming, Katrina Tan Yi Jun, Guillaume Carissimo   +2 more
doaj   +1 more source

The Mayaro virus and its potential epidemiological consequences in Colombia: an exploratory biomathematics analysis

Parasites & Vectors, 2020
Background Mayaro virus (Togaviridae) is an endemic arbovirus of the Americas with epidemiological similarities with the agents of other more prominent diseases such as dengue (Flaviviridae), Zika (Flaviviridae), and chikungunya (Togaviridae).
Bryan Steven Valencia-Marín, Irene Duarte Gandica, Oscar Alexander Aguirre-Obando   +2 more
doaj   +1 more source

Comparative analysis of the extent of protein–protein interactions in icosahedral viral capsids

Protein Science, Volume 34, Issue 9, September 2025.
Abstract Nonenveloped viruses package, carry, and deliver their genomes to the targeted cells using protein shells known as capsids. The viral capsids come in different shapes and sizes, most exhibiting helical or icosahedral symmetries. Here, we analyzed 634 icosahedral capsids at high resolution (<4 Å) from 39 virus families with T‐numbers ranging ...
Noah J. Zimmerman, Oscar Rojas Labra, Vijay S. Reddy   +2 more
wiley   +1 more source

Burden of Chikungunya Fever and Its Economic and Social Impacts Worldwide: A Systematic Review

Tropical Medicine &International Health, Volume 30, Issue 9, Page 865-892, September 2025.
ABSTRACT Objectives This study aimed to investigate the social and economic impacts and disease burden of Chikungunya Fever globally through a systematic literature review. Methods We performed a comprehensive literature search through MEDLINE (via PubMed), LILACS, and Embase databases, and grey literature, including studies of populations diagnosed ...
Vaneide Daciane Pedí, Giovanny Vinícius Araújo de França, Viviane Bellini Rodrigues, Felipe Tavares Duailibe, Marcella T. P. Santos, Maria Regina Fernandes de Oliveira   +5 more
wiley   +1 more source

The Journey of in vivo Virus Engineered Dendritic Cells From Bench to Bedside: A Bumpy Road

Frontiers in Immunology, 2018
Dendritic cells (DCs) are recognized as highly potent antigen-presenting cells that are able to stimulate cytotoxic T lymphocyte (CTL) responses with antitumor activity.
Cleo Goyvaerts, Karine Breckpot
doaj   +1 more source

The Aedes aegypti Domino Ortholog p400 Regulates Antiviral Exogenous Small Interfering RNA Pathway Activity and ago-2 Expression

mSphere, 2020
Arboviruses are pathogens of humans and animals. A better understanding of the interactions between these pathogens and the arthropod vectors, such as mosquitoes, that transmit them is necessary to develop novel control measures.
Melanie McFarlane, Floriane Almire, Joy Kean, Claire L. Donald, Alma McDonald, Bryan Wee, Mathilde Lauréti, Margus Varjak, Sandra Terry, Marie Vazeille, Rommel J. Gestuveo, Isabelle Dietrich, Colin Loney, Anna-Bella Failloux, Esther Schnettler, Emilie Pondeville, Alain Kohl   +16 more
doaj   +1 more source

The Antiviral Activity of Polyphenols

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Polyphenols demonstrate remarkable antiviral properties by effectively disrupting multiple biochemical processes essential for viral replication. ABSTRACT Polyphenols are secondary metabolites produced by a large variety of plants. These compounds that comprise the class of phenolic acids, stilbenes, lignans, coumarins, flavonoids, and tannins have a ...
Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu   +5 more
wiley   +1 more source

Salt and Pepper Pigmentary Retinopathy in Congenital Rubella Syndrome: A Case Report [PDF]

Journal of Clinical and Diagnostic Research
A fatal viral infection called rubella, often known as German or three-day measles, is spread by the Rubivirus genus of the Togaviridae family. The disorder known as Congenital Rubella Syndrome (CRS) has the potential to cause a wide range of multisystem
Raina Jain, Sachin Daigavane
doaj   +1 more source

Caracterización clínica y diagnóstica de chikungunya en el municipio de San Luis Jilotepeque [PDF]

, 2016
El Chikungunya es una enfermedad emergente transmitida por mosquitos. Es un virus ARN del género Alfavirus de la familia Togaviridae. “Chikungunya” es una voz del idioma Kimakonde que significa “doblarse”, en alusión al aspecto encorvado de los pacientes
Barrientos Oliva, GladYs Argelia, Orozco España, Flor de María   +1 more
core  

First Phosphonic‐Type Inhibitors and Activity‐Based Probes Specific to the O'nyong‐nyong Virus Capsid Protease

ChemMedChem, Volume 20, Issue 12, June 17, 2025.
The serine capsid protease (CP) catalyzes a crucial process of the alphaviral replication cycle; therefore, it constitutes an interesting therapy target. Herein, the O'nyong‐nyong virus CP profile activity with a specific fluorogenic substrate is analyzed and examines the inhibitory activity of a new series of phosphonic analogs of tryptophan and ...
Karolina Torzyk‐Jurowska, Agnieszka Łupicka‐Słowik, Renata Grzywa, Yuliya Chykunova, Krzysztof Pyrć, Marcin Sieńczyk   +5 more
wiley   +1 more source