Results 11 to 20 of about 190,847 (266)

Aneuploidy: Tolerating Tolerance [PDF]

open access: yesCurrent Biology, 2015
Individuals, and cells, vary in their ability to tolerate aneuploidy, an unbalanced chromosome complement. Tolerance mechanisms can be karyotype-specific or general. General tolerance mechanisms may allow cells to benefit from the phenotypic plasticity conferred by access to multiple aneuploid states.
Cromie, Gareth A., Dudley, Aimée M.
openaire   +2 more sources

The Recognition of Tolerance and Bounded Tolerance Graphs [PDF]

open access: yesSIAM Journal on Computing, 2011
Tolerance graphs model interval relations in such a way that intervals can tolerate a certain degree of overlap without being in conflict. This subclass of perfect graphs has been extensively studied, due to both its interesting structure and its numerous applications.
George B. Mertzios   +2 more
openaire   +7 more sources

Golimumab for Treating Chronic Inflammatory Joint Diseases in the Adult Population: Clinical Efficacy and Tolerability

open access: yesВопросы современной педиатрии, 2019
Due to the recent introduction of golimumab into paediatric rheumatology practice, an overview of the clinical studies of this tumour necrosis factor alpha inhibitor, most of which were conducted with adult patients with rheumatic diseases, has been ...
Natal’ya N. Chichasova
doaj   +1 more source

Delphi consensus recommendation for optimization of pulmonary hypertension therapy focusing on switching from a phosphodiesterase 5 inhibitor to riociguat

open access: yesPulmonary Circulation, 2022
Dual combination therapy with a phosphodiesterase‐5 inhibitor (PDE5i) and endothelin receptor antagonist is recommended for most patients with intermediate‐risk pulmonary arterial hypertension (PAH). The RESPITE and REPLACE studies suggest that switching
Franck F. Rahaghi   +19 more
doaj   +1 more source

Pharmacokinetic variables of medium molecular weight cross linked chitosan nanoparticles to enhance the bioavailability of 5-fluorouracil and reduce the acute oral toxicity

open access: yesDrug Delivery, 2021
To prepare glutaraldehyde-based cross-linked medium molecular weight chitosan nanoparticles encapsulated with 5-Fluorouracil (5-FU), to overcome dosing frequency as well as reducing acute oral toxicity and poor bioavailability of the drug.
Aisha Sethi   +3 more
doaj   +1 more source

Systematic Review on the Safety and Tolerability of Transcranial Direct Current Stimulation in Children and Adolescents

open access: yesBrain Sciences, 2021
Background: Transcranial direct current stimulation (tDCS) is a safe, tolerable, and acceptable technique in adults. However, there is limited evidence for its safety in youth.
Derrick Matthew Buchanan   +5 more
doaj   +1 more source

Indices of homeostasis in cattle after treatment with supramolecular complex of fenbendazole

open access: yesРоссийский паразитологический журнал, 2019
The purpose of the research: to study the tolerability of supramolecular complex of fenbendazole (SMCF) by cattle. Materials and methods. Research was conducted in Tepelevo from Dalnekonstantinovsky district of the Nizhny Novgorod region on 20 heifers at
A. I. Varlamova, I. A. Arkhipov
doaj   +1 more source

Extending single tolerances to set tolerances [PDF]

open access: yesDiscrete Applied Mathematics, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Gerold Jäger, Marcel Turkensteen
openaire   +1 more source

Donanemab (LY3002813) dose‐escalation study in Alzheimer's disease

open access: yesAlzheimer’s & Dementia: Translational Research & Clinical Interventions, 2021
Introduction This study explored the safety and tolerability features of donanemab (LY3002813) in patients with mild cognitive impairment due to Alzheimer's disease (AD) or mild to moderate AD dementia.
Stephen Loucian Lowe   +8 more
doaj   +1 more source

The Immune Tolerance Network: tolerance at the crossroads [PDF]

open access: yesPhilosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 2001
Immune tolerance therapies are designed to reprogramme immune cells in a highly specific fashion in order to eliminate pathogenic responses but preserve normal immune function. A concept that has tantalized immunologists for decades, tolerogenic therapies would replace current lifelong immunosuppressive regimens and their often debilitating side ...
J A, Bluestone, J, Matthews
openaire   +2 more sources

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