Results 11 to 20 of about 341,593 (314)

Effect of a sustained-release formulation of β-alanine on laboratory parameters and paresthesia in recreational trained men: a randomized double-blind placebo-controlled study

Frontiers in Nutrition, 2023
IntroductionBeta-alanine is a non-essential amino acid that has been a focus of increasing research by its role as ergogenic aid to improve muscle performance.MethodsA randomized, double-blind and controlled trial was conducted to determine the effect of
Ana Belén Maestre-Hernández, Silvia Pérez-Piñero, Francisco Javier López-Román, Francisco Javier López-Román, Luis Andreu-Caravaca, Luis Andreu-Caravaca, Antonio J. Luque-Rubia, Domingo J. Ramos-Campo, María José Díaz-Silvestre, Vicente Ávila-Gandía   +9 more
doaj   +1 more source

Safety, tolerability and pharmacokinetics of forsythin in healthy subjects: a double-blinded, placebo-controlled single-dose and multiple-dose escalation and food effect study

Annals of Medicine, 2023
Background Forsythin, an active compound from Forsythiae Fructus, has the potential to treat the common cold and influenza through its antipyretic-analgesic, anti-inflammatory and antiviral effects.
Cuiyun Li, Min Wu, Hong Zhang, Xiaoxue Zhu, Li Fu, Shuo Wang, Mingming Lu, Dafang Zhong, Yanhua Ding   +8 more
doaj   +1 more source

Aneuploidy: Tolerating Tolerance [PDF]

Current Biology, 2015
Individuals, and cells, vary in their ability to tolerate aneuploidy, an unbalanced chromosome complement. Tolerance mechanisms can be karyotype-specific or general. General tolerance mechanisms may allow cells to benefit from the phenotypic plasticity conferred by access to multiple aneuploid states.
Cromie, Gareth A., Dudley, Aimée M.
openaire   +2 more sources

Study of the effect of food on the bioavailability, safety and tolerability of Aterixen^® 100 mg tablet in healthy volunteers

Фармакокинетика и Фармакодинамика, 2023
The aim. The primary objective of the study was to evaluate the effect of food on the bioavailability of Aterixen® 100 mg tablet after single oral dose under fasting or fed conditions.
V. B. Vasilyuk, Yu. A. Dzhurko, A. A. Globenko, L. N. Schitov, V. N. Shabrov, M. A. Pasko, O. V. Kovchan, A. V. Kapashin, A. I. Bashkatova   +8 more
doaj   +1 more source

High Doses of Second-Generation Long-Acting Antipsychotics in the Treatment of Patients with Severe Resistant Schizophrenia: A Six-Year Mirror-Image Study

Psychiatry and Clinical Psychopharmacology, 2021
Background: This study explores whether high-dose treatment with second-generation antipsychotic long-acting injectable (SGA LAI) may benefit patients with schizophrenia that are inadequately controlled on a standard dose.
Juan J. Fernández-Miranda, Silvia Díaz-Fernández, Francisco López-Muñoz   +2 more
doaj   +1 more source

Effectiveness and tolerability of aripiprazole in a real-world outpatient population of youth

Psychiatry and Clinical Psychopharmacology, 2021
Objectives: To identify the pattern of initiation for offlabel use of aripiprazole among adolescent outpatients; determine whether or not aripiprazole is effective and tolerable for the treatment of adolescents with a wide range of psychiatric symptoms ...
Tezan Bildik, Sezen Kose, Saniye Korkmaz Cetin, Nazli Burcu Ozbaran   +3 more
doaj   +1 more source

Tolerability and pharmacokinetics of two antimony products after subcutaneous administration in dogs

Journal of Infection in Developing Countries, 2018
Introduction: Pentavalent antimony is the first choice drug for leishmaniasis in dog. Leishmaniasis has a complex pathogenesis and it manifests various clinical signs, some of which are often similar to those associated with the toxicity induced by ...
Julie Rambaldi, Andrea Barbarossa, Eva Morbidelli, Anna Zaghini   +3 more
doaj   +1 more source

Tolerability Profile of Antiparasitic Drug «Gelmintal Mini Syrup» Administered as a Single and Repeated Dose to Target Animal Species

Российский паразитологический журнал, 2020
The purpose of the research is studying the tolerability profile of drug» Gelmintal Mini Syrup» based on toltrazuril and moxidectin in therapeutic and increased doses administered once and repeatedly to target animal species. Materials and methods.
G. B. Arisova, M. V. Arisov, I. A. Stepanova, V. V. Khristenko   +3 more
doaj   +1 more source

Adequate Colon Preparation in Screening Colonoscopy [PDF]

Modern Medicine
Colorectal cancer (CRC) is one of the most common forms of cancer worldwide, being the fourth most prevalent cancer and the third most common in terms of mortality.
Marina COZMA, Elena CONSTANTIN, Lucian NEGREANU   +2 more
doaj   +1 more source

Doxorubicin/Adriamycin Monotherapy or Plus Ifosfamide in First-Line Treatment for Advanced Soft Tissue Sarcoma: A Pooled Analysis of Randomized Trials

Frontiers in Oncology, 2021
BackgroundDoxorubicin/Adriamycin (ADM) alone or combined with ifosfamide (IFO) (AI) is available for previously untreated advanced soft tissue sarcoma (ASTS). However, the clinical choice between them remains controversial.
Bi-Cheng Wang, Bo-Hua Kuang, Bo-Ya Xiao, Bo-Ya Xiao, Guo-He Lin   +4 more
doaj   +1 more source