Results 31 to 40 of about 341,593 (314)

Rapid Absorption of Naloxone from Eye Drops

Pharmaceuticals, 2022
Naloxone as emergency treatment for opioid overdosing can be administered via several routes. However, the available administration methods are invasive or may be associated with incomplete or slow naloxone absorption.
Johanna Tuunainen, Lasse Saloranta, Jouko Levijoki, Jenni Lindstedt, Jenni Lehtisalo, Sari Pappinen, Meri Ramela, Sami Virtanen, Heikki Joensuu   +8 more
doaj   +1 more source

Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study [PDF]

, 2019
Background: Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment.
Allegretti, M., Ferrari, M., Garhoefer, G., Lambiase, A., Mantelli, F., Sacchetti, M., Schmetterer, L., Schmidl, D.   +7 more
core   +1 more source

A first-in-human, open-label, dose-escalation and dose-expansion phase I study to evaluate the safety, tolerability, pharmacokinetics/pharmacodynamics, and antitumor activity of QL1604, a humanized anti–PD-1 mAb, in patients with advanced or metastatic solid tumors

Frontiers in Immunology, 2023
BackgroundQL1604 is a humanized immunoglobulin G4 monoclonal antibody against programmed cell death protein 1. This first-in-human, open-label phase I study aimed to investigate the safety and tolerability and to identify the recommended doses of QL1604 ...
Zhiyu Huang, Yanjun Xu, Wei Hong, Lei Gong, Kaiyan Chen, Jing Qin, Fajun Xie, Feng Wang, Xin Tian, Xiangrui Meng, Wenlei Feng, Lingyan Li, Baihui Zhang, Xiaoyan Kang, Yun Fan   +14 more
doaj   +1 more source

The SGLT2 inhibitor empagliflozin for the treatment of type 2 diabetes mellitus: A bench to bedside review [PDF]

, 2014
INTRODUCTION: The treatment of type 2 diabetes mellitus (T2DM) continues to pose challenges for clinicians and patients. The dramatic rise in T2DM prevalence, which has paralleled the rise in obesity, has strained the healthcare system and prompted the ...
McGill, Janet B
core   +2 more sources

Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders. [PDF]

, 2014
Methylphenidate (MPH) reduces hyperactive-impulsive symptoms common in children with autism spectrum disorders (ASDs), however, response and tolerability varies widely.
Aman, MG, Arnold, LE, Badashova, KK, Chuang, SZ, Davies, M, McCracken, JT, McDougle, CJ, Nurmi, EL, Posey, DJ, Scahill, L, Shah, B, Tierney, E, Vitiello, B, Whelan, F   +13 more
core  

Infectious tolerance

Current Opinion in Immunology, 1998
Infectious tolerance can be induced in many ways, does not require a thymus or clonal deletion and can spread to third-party antigens linked on the same antigen-presenting cell-the process being variously described as linked-, bystanderor epitope-suppression.
Cobbold, S, Waldmann, H
openaire   +2 more sources

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne. [PDF]

, 2019
BACKGROUND: Acne vulgaris often affects the face, shoulders, chest, and back, but treatment of nonfacial acne has not been rigorously studied. OBJECTIVES: Assess the safety and efficacy of trifarotene 50 μg/g cream, a novel topical retinoid, in moderate ...
Ahmad, Faiz, Alió Saenz, Alessandra, Blume-Peytavi, Ulrike, Del Rosso, James, Gooderham, Melinda, Graeber, Michael, Johnson, Sandra, Lynde, Charles, Parish, Lawrence, Popp, Georg, Sanchez Colon, Nestor, Stein Gold, Linda, Tan, Jerry, Thiboutot, Diane, Weglovska, Jolanta, Weiss, Jonathan, Witkowska, Dagmara   +16 more
core   +1 more source

Efficacy of Prucalopride in bowel cleansing before colonoscopy. Results of a pilot study [PDF]

, 2017
Colonoscopy is a crucial diagnostic instrument for colorectal cancer screening and an adequate bowel preparation is definitely decisive for the success of the procedure.
Antonelli, Giulio, Coluccio, Chiara, Corleto, Vito Domenico, D'Alba, Lucia, di Giulio, Emilio   +4 more
core   +1 more source

Safety and tolerability of repetitive transcranial magnetic stimulation: an analysis of over 1200 sessions

Неврология, нейропсихиатрия, психосоматика, 2023
Transcranial magnetic stimulation (TMS) is increasingly used in research and clinical practice, therefore, the issues of its safety and tolerability are especially important. Currently, serious adverse reactions (ARs) are extremely rare.
I. S. Bakulin, A. Kh. Zabirova, A. G. Poydasheva, D. Yu. Lagoda, N. A. Suponeva, M. A. Piradov   +5 more
doaj   +1 more source