Results 191 to 200 of about 190,847 (266)

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source

Correction: Safety and Tolerability of Edoxaban in Filipino Patients With Non-valvular Atrial Fibrillation: A Pilot Post-marketing Surveillance Study. [PDF]

Cureus
Bernan AP, Santos AGV.
europepmc   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Study protocol for a phase I investigator-initiated clinical trial of E7820 in Japanese patients with unresectable solid tumours: CIRCUS trial (NCCH2303). [PDF]

Jpn J Clin Oncol
Okada M, Sato J, Funasaka C, Yamamoto N, Sasaki T, Yokoyama M, Hamada A, Doi T, Mano H.   +8 more
europepmc   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Sex differences in the long-term tolerability of BNT162b2 in children and adolescents. [PDF]

Mol Cell Pediatr
Moor J, Grieshaber V, Toepfner N, Holzwarth S, Moor MB, Kublickiene K, Strumann C, Chao CM.   +7 more
europepmc   +1 more source

Topical Retinoids in Acne Vulgaris and Acne Scars-From Monotherapy to Combining Regimens. [PDF]

Pharmaceuticals (Basel)
Tobiasz A, Jankowska-Konsur A, Nowicka D.   +2 more
europepmc   +1 more source

Revisiting the Ethics of Urate‐Lowering Therapy Clinical Trials for Gout Management

Arthritis &Rheumatology, EarlyView.
Lisa K. Stamp, Dien Ho, Nicola Dalbeth
wiley   +1 more source

Usability, acceptability, and tolerability of a virtual reality patient tour compared to an educational video in cardiac surgery patients - A feasibility study. [PDF]

PEC Innov
Cardol CM, de Heer LM, Marsman M, van Rijn MM, Weldam SWM.   +4 more
europepmc   +1 more source